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146 related items for PubMed ID: 21751815

  • 1. New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.
    Anzini M, Valenti S, Braile C, Cappelli A, Vomero S, Alcaro S, Ortuso F, Marinelli L, Limongelli V, Novellino E, Betti L, Giannaccini G, Lucacchini A, Daniele S, Martini C, Ghelardini C, Di Cesare Mannelli L, Giorgi G, Mascia MP, Biggio G.
    J Med Chem; 2011 Aug 25; 54(16):5694-711. PubMed ID: 21751815
    [Abstract] [Full Text] [Related]

  • 2. Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands.
    Kelly MD, Smith A, Banks G, Wingrove P, Whiting PW, Atack J, Seabrook GR, Maubach KA.
    Br J Pharmacol; 2002 Jan 25; 135(1):248-56. PubMed ID: 11786501
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.
    Cappelli A, Anzini M, Vomero S, Menziani MC, De Benedetti PG, Sbacchi M, Clarke GD, Mennuni L.
    J Med Chem; 1996 Feb 16; 39(4):860-72. PubMed ID: 8632410
    [Abstract] [Full Text] [Related]

  • 4. Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
    Anzini M, Braile C, Valenti S, Cappelli A, Vomero S, Marinelli L, Limongelli V, Novellino E, Betti L, Giannaccini G, Lucacchini A, Ghelardini C, Norcini M, Makovec F, Giorgi G, Ian Fryer R.
    J Med Chem; 2008 Aug 14; 51(15):4730-43. PubMed ID: 18637672
    [Abstract] [Full Text] [Related]

  • 5. Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
    Cappelli A, Anzini M, Castriconi F, Grisci G, Paolino M, Braile C, Valenti S, Giuliani G, Vomero S, Di Capua A, Betti L, Giannaccini G, Lucacchini A, Ghelardini C, Di Cesare Mannelli L, Frosini M, Ricci L, Giorgi G, Mascia MP, Biggio G.
    J Med Chem; 2016 Apr 14; 59(7):3353-72. PubMed ID: 26982523
    [Abstract] [Full Text] [Related]

  • 6. [3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits.
    Skolnick P, Hu RJ, Cook CM, Hurt SD, Trometer JD, Liu R, Huang Q, Cook JM.
    J Pharmacol Exp Ther; 1997 Nov 14; 283(2):488-93. PubMed ID: 9353361
    [Abstract] [Full Text] [Related]

  • 7. Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.
    Anzini M, Canullo L, Braile C, Cappelli A, Gallelli A, Vomero S, Menziani MC, De Benedetti PG, Rizzo M, Collina S, Azzolina O, Sbacchi M, Ghelardini C, Galeotti N.
    J Med Chem; 2003 Aug 28; 46(18):3853-64. PubMed ID: 12930147
    [Abstract] [Full Text] [Related]

  • 8. 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.
    Lager E, Andersson P, Nilsson J, Pettersson I, Nielsen EØ, Nielsen M, Sterner O, Liljefors T.
    J Med Chem; 2006 Apr 20; 49(8):2526-33. PubMed ID: 16610795
    [Abstract] [Full Text] [Related]

  • 9. Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.
    Tan KR, Baur R, Gonthier A, Goeldner M, Sigel E.
    FEBS Lett; 2007 Oct 02; 581(24):4718-22. PubMed ID: 17854801
    [Abstract] [Full Text] [Related]

  • 10. Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
    Whittemore ER, Yang W, Drewe JA, Woodward RM.
    Mol Pharmacol; 1996 Nov 02; 50(5):1364-75. PubMed ID: 8913369
    [Abstract] [Full Text] [Related]

  • 11. Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.
    Nilsson J, Gidlöf R, Nielsen EØ, Liljefors T, Nielsen M, Sterner O.
    Bioorg Med Chem; 2011 Jan 01; 19(1):111-21. PubMed ID: 21163663
    [Abstract] [Full Text] [Related]

  • 12. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.
    J Neurochem; 2008 Sep 01; 106(6):2353-63. PubMed ID: 18643789
    [Abstract] [Full Text] [Related]

  • 13. The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present.
    McKernan RM, Wafford K, Quirk K, Hadingham KL, Harley EA, Ragan CI, Whiting PJ.
    J Recept Signal Transduct Res; 1995 Sep 01; 15(1-4):173-83. PubMed ID: 8903939
    [Abstract] [Full Text] [Related]

  • 14. Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors.
    Wafford KA, Bain CJ, Whiting PJ, Kemp JA.
    Mol Pharmacol; 1993 Aug 01; 44(2):437-42. PubMed ID: 8102787
    [Abstract] [Full Text] [Related]

  • 15. Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies.
    Huh KH, Delorey TM, Endo S, Olsen RW.
    Mol Pharmacol; 1995 Oct 01; 48(4):666-75. PubMed ID: 7476892
    [Abstract] [Full Text] [Related]

  • 16. In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.
    Atack JR, Alder L, Cook SM, Smith AJ, McKernan RM.
    Neuropharmacology; 2005 Aug 01; 49(2):220-9. PubMed ID: 15996568
    [Abstract] [Full Text] [Related]

  • 17. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.
    Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W.
    Biochem Pharmacol; 2004 Oct 15; 68(8):1621-9. PubMed ID: 15451405
    [Abstract] [Full Text] [Related]

  • 18. Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.
    Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ.
    Mol Pharmacol; 1996 Feb 15; 49(2):253-9. PubMed ID: 8632757
    [Abstract] [Full Text] [Related]

  • 19. New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular modeling investigation.
    Guerrini G, Ciciani G, Bruni F, Selleri S, Guarino C, Melani F, Montali M, Daniele S, Martini C, Ghelardini C, Norcini M, Ciattini S, Costanzo A.
    J Med Chem; 2010 Nov 11; 53(21):7532-48. PubMed ID: 20939501
    [Abstract] [Full Text] [Related]

  • 20. gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands.
    Massotti M, Schlichting JL, Antonacci MD, Giusti P, Memo M, Costa E, Guidotti A.
    J Pharmacol Exp Ther; 1991 Mar 11; 256(3):1154-60. PubMed ID: 1848629
    [Abstract] [Full Text] [Related]

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