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181 related items for PubMed ID: 2176803

  • 1. The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrations.
    Houslay MD.
    Cell Signal; 1990; 2(1):85-98. PubMed ID: 2176803
    [Abstract] [Full Text] [Related]

  • 2. An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations.
    Heyworth CM, Wallace AV, Wilson SR, Houslay MD.
    Biochem J; 1984 Aug 15; 222(1):183-7. PubMed ID: 6089756
    [Abstract] [Full Text] [Related]

  • 3. N6-(Phenylisopropyl)adenosine prevents glucagon both blocking insulin's activation of the plasma-membrane cyclic AMP phosphodiesterase and uncoupling hormonal stimulation of adenylate cyclase activity in hepatocytes.
    Wallace AV, Heyworth CM, Houslay MD.
    Biochem J; 1984 Aug 15; 222(1):177-82. PubMed ID: 6089755
    [Abstract] [Full Text] [Related]

  • 4. Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes.
    Irvine F, Wallace AV, Sarawak SR, Houslay MD.
    Biochem J; 1993 Jul 01; 293 ( Pt 1)(Pt 1):249-53. PubMed ID: 8392336
    [Abstract] [Full Text] [Related]

  • 5. Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes.
    Heyworth CM, Wallace AV, Houslay MD.
    Biochem J; 1983 Jul 15; 214(1):99-110. PubMed ID: 6311178
    [Abstract] [Full Text] [Related]

  • 6. Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat.
    Pyne NJ, Anderson N, Lavan BE, Milligan G, Nimmo HG, Houslay MD.
    Biochem J; 1987 Dec 15; 248(3):897-901. PubMed ID: 2829845
    [Abstract] [Full Text] [Related]

  • 7. An insulin mediator preparation serves to stimulate the cyclic GMP activated cyclic AMP phosphodiesterase rather than other purified insulin-activated cyclic AMP phosphodiesterases.
    Pyne NJ, Houslay MD.
    Biochem Biophys Res Commun; 1988 Oct 14; 156(1):290-6. PubMed ID: 2845976
    [Abstract] [Full Text] [Related]

  • 8. Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.
    Murphy GJ, Houslay MD.
    Biochem J; 1988 Jan 15; 249(2):543-7. PubMed ID: 2449179
    [Abstract] [Full Text] [Related]

  • 9. The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.
    Heyworth CM, Grey AM, Wilson SR, Hanski E, Houslay MD.
    Biochem J; 1986 Apr 01; 235(1):145-9. PubMed ID: 3017298
    [Abstract] [Full Text] [Related]

  • 10. Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form.
    Lavan BE, Lakey T, Houslay MD.
    Biochem Pharmacol; 1989 Nov 15; 38(22):4123-36. PubMed ID: 2480793
    [Abstract] [Full Text] [Related]

  • 11. The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity.
    Pyne NJ, Cooper ME, Houslay MD.
    Biochem J; 1987 Feb 15; 242(1):33-42. PubMed ID: 3036087
    [Abstract] [Full Text] [Related]

  • 12. Treatment of intact hepatocytes with the calcium ionophore A23187 perturbs both the synthesis and the degradation of the second messenger cyclic AMP. Actions on adenylate cyclase and cyclic AMP phosphodiesterase activities.
    Irvine FJ, Houslay MD.
    Biochem Pharmacol; 1988 Jul 15; 37(14):2773-9. PubMed ID: 2456067
    [Abstract] [Full Text] [Related]

  • 13. Insulin trigger, cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase.
    Marchmont RJ, Houslay MD.
    Nature; 1980 Aug 28; 286(5776):904-6. PubMed ID: 6251375
    [Abstract] [Full Text] [Related]

  • 14. Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes.
    Wilson SR, Wallace AV, Houslay MD.
    Biochem J; 1983 Oct 15; 216(1):245-8. PubMed ID: 6316937
    [Abstract] [Full Text] [Related]

  • 15. Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase.
    Anderson NG, Kilgour E, Houslay MD.
    Biochem J; 1989 Sep 15; 262(3):867-72. PubMed ID: 2556112
    [Abstract] [Full Text] [Related]

  • 16. Activation and phosphorylation of the 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase.
    Kilgour E, Anderson NG, Houslay MD.
    Biochem J; 1989 May 15; 260(1):27-36. PubMed ID: 2549954
    [Abstract] [Full Text] [Related]

  • 17. Cross-talk between glucagon- and adenosine-mediated signalling systems in rat hepatocytes: effects on cyclic AMP-phosphodiesterase activity.
    Robles-Flores M, Allende G, Piña E, García-Sáinz JA.
    Biochem J; 1995 Dec 15; 312 ( Pt 3)(Pt 3):763-7. PubMed ID: 8554517
    [Abstract] [Full Text] [Related]

  • 18. Multiple molecular forms of phosphodiesterase and the regulation of cardiac muscle contractility.
    Weishaar RE, Kobylarz-Singer DC, Quade MM, Steffen RP, Kaplan HR.
    J Cyclic Nucleotide Protein Phosphor Res; 1995 Dec 15; 11(7):513-27. PubMed ID: 2831259
    [Abstract] [Full Text] [Related]

  • 19. The phorbol ester TPA inhibits cyclic AMP phosphodiesterase activity in intact hepatocytes.
    Irvine F, Pyne NJ, Houslay MD.
    FEBS Lett; 1986 Nov 24; 208(2):455-9. PubMed ID: 2430836
    [Abstract] [Full Text] [Related]

  • 20. The phorbol ester TPA prevents the expression of both glucagon desensitisation and the glucagon-mediated block of insulin stimulation of the peripheral plasma membrane cyclic AMP phosphodiesterase in rat hepatocytes.
    Heyworth CM, Wilson SP, Gawler DJ, Houslay MD.
    FEBS Lett; 1985 Aug 05; 187(2):196-200. PubMed ID: 2991013
    [Abstract] [Full Text] [Related]

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