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308 related items for PubMed ID: 21768356

  • 1. Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
    Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts AW.
    Proc Natl Acad Sci U S A; 2011 Aug 09; 108(32):13135-40. PubMed ID: 21768356
    [Abstract] [Full Text] [Related]

  • 2. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.
    Zhang J, Huang K, O'Neill KL, Pang X, Luo X.
    Cell Death Dis; 2016 Jun 16; 7(6):e2266. PubMed ID: 27310874
    [Abstract] [Full Text] [Related]

  • 3. Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.
    Lindqvist LM, Heinlein M, Huang DC, Vaux DL.
    Proc Natl Acad Sci U S A; 2014 Jun 10; 111(23):8512-7. PubMed ID: 24912196
    [Abstract] [Full Text] [Related]

  • 4. Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
    Chen S, Dai Y, Harada H, Dent P, Grant S.
    Cancer Res; 2007 Jan 15; 67(2):782-91. PubMed ID: 17234790
    [Abstract] [Full Text] [Related]

  • 5. BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
    Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N.
    Hepatology; 2009 Dec 15; 50(6):1972-80. PubMed ID: 19839062
    [Abstract] [Full Text] [Related]

  • 6. Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis.
    Clohessy JG, Zhuang J, de Boer J, Gil-Gómez G, Brady HJ.
    J Biol Chem; 2006 Mar 03; 281(9):5750-9. PubMed ID: 16380381
    [Abstract] [Full Text] [Related]

  • 7. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
    van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC.
    Cancer Cell; 2006 Nov 03; 10(5):389-99. PubMed ID: 17097561
    [Abstract] [Full Text] [Related]

  • 8. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
    Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.
    J Biol Chem; 2011 Mar 18; 286(11):9382-92. PubMed ID: 21148306
    [Abstract] [Full Text] [Related]

  • 9. BH3 domains other than Bim and Bid can directly activate Bax/Bak.
    Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.
    J Biol Chem; 2011 Jan 07; 286(1):491-501. PubMed ID: 21041309
    [Abstract] [Full Text] [Related]

  • 10. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
    Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.
    J Biol Chem; 2011 Apr 22; 286(16):13905-13. PubMed ID: 21367852
    [Abstract] [Full Text] [Related]

  • 11. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.
    Rahmani M, Aust MM, Attkisson E, Williams DC, Ferreira-Gonzalez A, Grant S.
    Cancer Res; 2013 Feb 15; 73(4):1340-51. PubMed ID: 23243017
    [Abstract] [Full Text] [Related]

  • 12. Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.
    Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.
    Cell Death Differ; 2012 Nov 15; 19(11):1856-69. PubMed ID: 22790873
    [Abstract] [Full Text] [Related]

  • 13. Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.
    Wang C, Youle RJ.
    Oncogene; 2012 Jun 28; 31(26):3177-89. PubMed ID: 22056880
    [Abstract] [Full Text] [Related]

  • 14. Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.
    Hockings C, Anwari K, Ninnis RL, Brouwer J, O'Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM.
    Cell Death Dis; 2015 Apr 23; 6(4):e1735. PubMed ID: 25906158
    [Abstract] [Full Text] [Related]

  • 15. Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.
    Hockings C, Alsop AE, Fennell SC, Lee EF, Fairlie WD, Dewson G, Kluck RM.
    Cell Death Differ; 2018 Mar 23; 25(4):721-734. PubMed ID: 29459767
    [Abstract] [Full Text] [Related]

  • 16. BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis.
    Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X.
    Cell Res; 2019 Nov 23; 29(11):942-952. PubMed ID: 31551537
    [Abstract] [Full Text] [Related]

  • 17. ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.
    Premkumar DR, Jane EP, DiDomenico JD, Vukmer NA, Agostino NR, Pollack IF.
    J Pharmacol Exp Ther; 2012 Jun 23; 341(3):859-72. PubMed ID: 22393246
    [Abstract] [Full Text] [Related]

  • 18. Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.
    Sutton VR, Sedelies K, Dewson G, Christensen ME, Bird PI, Johnstone RW, Kluck RM, Trapani JA, Waterhouse NJ.
    Cell Death Dis; 2012 Jul 05; 3(7):e344. PubMed ID: 22764103
    [Abstract] [Full Text] [Related]

  • 19. BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells.
    Huang S, Sinicrope FA.
    Cancer Res; 2008 Apr 15; 68(8):2944-51. PubMed ID: 18413764
    [Abstract] [Full Text] [Related]

  • 20. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
    Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.
    Science; 2007 Feb 09; 315(5813):856-9. PubMed ID: 17289999
    [Abstract] [Full Text] [Related]

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