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Journal Abstract Search

115 related items for PubMed ID: 21775153

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  • 2. Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.
    Milbank JB, Stevenson RJ, Ware DC, Chang JY, Tercel M, Ahn GO, Wilson WR, Denny WA.
    J Med Chem; 2009 Nov 12; 52(21):6822-34. PubMed ID: 19821576
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  • 3. Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs.
    Chang JY, Lu GL, Stevenson RJ, Brothers PJ, Clark GR, Botting KJ, Ferry DM, Tercel M, Wilson WR, Denny WA, Ware DC.
    Inorg Chem; 2013 Jul 01; 52(13):7688-98. PubMed ID: 23773210
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  • 4. The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins.
    Ashoorzadeh A, Atwell GJ, Pruijn FB, Wilson WR, Tercel M, Denny WA, Stevenson RJ.
    Bioorg Med Chem; 2011 Aug 15; 19(16):4851-60. PubMed ID: 21767954
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  • 5. Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.
    Ahn GO, Botting KJ, Patterson AV, Ware DC, Tercel M, Wilson WR.
    Biochem Pharmacol; 2006 Jun 14; 71(12):1683-94. PubMed ID: 16620789
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  • 6. Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.
    Stevenson RJ, Denny WA, Tercel M, Pruijn FB, Ashoorzadeh A.
    J Med Chem; 2012 Mar 22; 55(6):2780-802. PubMed ID: 22339090
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  • 7. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
    Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA.
    J Med Chem; 2003 Dec 04; 46(25):5533-45. PubMed ID: 14640560
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  • 13. Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
    Hay MP, Atwell GJ, Wilson WR, Pullen SM, Denny WA.
    J Med Chem; 2003 Jun 05; 46(12):2456-66. PubMed ID: 12773049
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  • 15. Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity.
    Milbank JB, Tercel M, Atwell GJ, Wilson WR, Hogg A, Denny WA.
    J Med Chem; 1999 Feb 25; 42(4):649-58. PubMed ID: 10052972
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  • 16. Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.
    Tercel M, Atwell GJ, Yang S, Stevenson RJ, Botting KJ, Boyd M, Smith E, Anderson RF, Denny WA, Wilson WR, Pruijn FB.
    J Med Chem; 2009 Nov 26; 52(22):7258-72. PubMed ID: 19877646
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  • 17. The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy.
    Stevenson RJ, Denny WA, Ashoorzadeh A, Pruijn FB, van Leeuwen WF, Tercel M.
    Bioorg Med Chem; 2011 Oct 15; 19(20):5989-98. PubMed ID: 21920763
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  • 18. Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators.
    Wilson WR, Stribbling SM, Pruijn FB, Syddall SP, Patterson AV, Liyanage HD, Smith E, Botting KJ, Tercel M.
    Mol Cancer Ther; 2009 Oct 15; 8(10):2903-13. PubMed ID: 19808982
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  • 19. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.
    Zhao RY, Erickson HK, Leece BA, Reid EE, Goldmacher VS, Lambert JM, Chari RV.
    J Med Chem; 2012 Jan 26; 55(2):766-82. PubMed ID: 22148292
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  • 20. Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA.
    Gieseg MA, Matejovic J, Denny WA.
    Anticancer Drug Des; 1999 Feb 26; 14(1):77-84. PubMed ID: 10363030
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