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179 related items for PubMed ID: 21784061

  • 1. Mcl-1 downregulation by YM155 contributes to its synergistic anti-tumor activities with ABT-263.
    Tang H, Shao H, Yu C, Hou J.
    Biochem Pharmacol; 2011 Nov 01; 82(9):1066-72. PubMed ID: 21784061
    [Abstract] [Full Text] [Related]

  • 2. YM155 enhances ABT-737-mediated apoptosis through Mcl-1 downregulation in Mcl-1-overexpressed cancer cells.
    Woo SM, Min KJ, Seo BR, Seo YH, Jeong YJ, Kwon TK.
    Mol Cell Biochem; 2017 May 01; 429(1-2):91-102. PubMed ID: 28120212
    [Abstract] [Full Text] [Related]

  • 3. YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context.
    Jane EP, Premkumar DR, DiDomenico JD, Hu B, Cheng SY, Pollack IF.
    Mol Cancer Ther; 2013 Mar 01; 12(3):326-38. PubMed ID: 23325792
    [Abstract] [Full Text] [Related]

  • 4. YM155 induces caspase-8 dependent apoptosis through downregulation of survivin and Mcl-1 in human leukemia cells.
    Feng W, Yoshida A, Ueda T.
    Biochem Biophys Res Commun; 2013 May 24; 435(1):52-7. PubMed ID: 23618862
    [Abstract] [Full Text] [Related]

  • 5. Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1.
    Wagner V, Hose D, Seckinger A, Weiz L, Meißner T, Rème T, Breitkreutz I, Podar K, Ho AD, Goldschmidt H, Krämer A, Klein B, Raab MS.
    Oncotarget; 2014 Nov 15; 5(21):10237-50. PubMed ID: 25296978
    [Abstract] [Full Text] [Related]

  • 6. YM155 induces apoptosis through downregulation of specificity protein 1 and myeloid cell leukemia-1 in human oral cancer cell lines.
    Sachita K, Yu HJ, Yun JW, Lee JS, Cho SD.
    J Oral Pathol Med; 2015 Nov 15; 44(10):785-91. PubMed ID: 25475012
    [Abstract] [Full Text] [Related]

  • 7. Autophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells.
    Chiou JT, Lee YC, Huang CH, Shi YJ, Wang LJ, Chang LS.
    Toxicol Appl Pharmacol; 2020 Jan 15; 387():114857. PubMed ID: 31837377
    [Abstract] [Full Text] [Related]

  • 8. Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway.
    Premkumar DR, Jane EP, Foster KA, Pollack IF.
    J Pharmacol Exp Ther; 2013 Aug 15; 346(2):201-10. PubMed ID: 23740602
    [Abstract] [Full Text] [Related]

  • 9. AML sensitivity to YM155 is modulated through AKT and Mcl-1.
    de Necochea-Campion R, Diaz Osterman CJ, Hsu HW, Fan J, Mirshahidi S, Wall NR, Chen CS.
    Cancer Lett; 2015 Sep 28; 366(1):44-51. PubMed ID: 26118775
    [Abstract] [Full Text] [Related]

  • 10. YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells.
    Woo SM, Min KJ, Seo BR, Kwon TK.
    Oncotarget; 2016 Sep 20; 7(38):61520-61532. PubMed ID: 27528031
    [Abstract] [Full Text] [Related]

  • 11. YM155 induces EGFR suppression in pancreatic cancer cells.
    Na YS, Yang SJ, Kim SM, Jung KA, Moon JH, Shin JS, Yoon DH, Hong YS, Ryu MH, Lee JL, Lee JS, Kim TW.
    PLoS One; 2012 Sep 20; 7(6):e38625. PubMed ID: 22723871
    [Abstract] [Full Text] [Related]

  • 12. Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells.
    Jung SA, Park YM, Hong SW, Moon JH, Shin JS, Lee HR, Ha SH, Lee DH, Kim JH, Kim SM, Kim JE, Kim KP, Hong YS, Choi EK, Lee JS, Jin DH, Kim T.
    J Biol Chem; 2015 Apr 17; 290(16):9974-85. PubMed ID: 25635055
    [Abstract] [Full Text] [Related]

  • 13. Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS.
    Minoda M, Kawamoto T, Ueha T, Kamata E, Morishita M, Harada R, Toda M, Onishi Y, Hara H, Kurosaka M, Akisue T.
    Int J Oncol; 2015 Sep 17; 47(3):891-9. PubMed ID: 26166250
    [Abstract] [Full Text] [Related]

  • 14. YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma.
    Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H.
    Pharmacol Res; 2017 Jun 17; 120():242-251. PubMed ID: 28396094
    [Abstract] [Full Text] [Related]

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  • 16. Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma.
    Zhao X, Puszyk WM, Lu Z, Ostrov DA, George TJ, Robertson KD, Liu C.
    Mol Cancer Ther; 2015 Jan 17; 14(1):80-9. PubMed ID: 25344582
    [Abstract] [Full Text] [Related]

  • 17. Small Molecule Survivin Inhibitor YM155 Displays Potent Activity Against Human Osteosarcoma Cells.
    Zhang S, Wang X, Gu Z, Wang L.
    Cancer Invest; 2016 Sep 13; 34(8):401-7. PubMed ID: 27559851
    [Abstract] [Full Text] [Related]

  • 18. Action of YM155 on clear cell renal cell carcinoma does not depend on survivin expression levels.
    Sim MY, Huynh H, Go ML, Yuen JSP.
    PLoS One; 2017 Sep 13; 12(6):e0178168. PubMed ID: 28582447
    [Abstract] [Full Text] [Related]

  • 19. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells.
    Cheng SM, Chang YC, Liu CY, Lee JY, Chan HH, Kuo CW, Lin KY, Tsai SL, Chen SH, Li CF, Leung E, Kanwar JR, Huang CC, Chang JY, Cheung CH.
    Br J Pharmacol; 2015 Jan 13; 172(1):214-34. PubMed ID: 25220225
    [Abstract] [Full Text] [Related]

  • 20. Commitment toward cell death by activation of autophagy with survivin inhibitor YM155 in two canine squamous cell carcinoma cell lines with high expression of survivin.
    Miyamoto R, Tani H, Ikeda T, Saima H, Tamura K, Bonkobara M.
    Res Vet Sci; 2021 Mar 13; 135():412-415. PubMed ID: 33160684
    [Abstract] [Full Text] [Related]

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