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321 related items for PubMed ID: 21793854

  • 1. Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.
    Keum YS.
    Ann N Y Acad Sci; 2011 Jul; 1229():184-9. PubMed ID: 21793854
    [Abstract] [Full Text] [Related]

  • 2. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
    Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.
    Mol Cell Biol; 2004 Dec; 24(24):10941-53. PubMed ID: 15572695
    [Abstract] [Full Text] [Related]

  • 3. Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.
    Hong F, Freeman ML, Liebler DC.
    Chem Res Toxicol; 2005 Dec; 18(12):1917-26. PubMed ID: 16359182
    [Abstract] [Full Text] [Related]

  • 4. Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).
    Wong DP, Wells G, Hagen T.
    Eur J Pharmacol; 2010 Sep 25; 643(2-3):188-94. PubMed ID: 20599909
    [Abstract] [Full Text] [Related]

  • 5. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
    Villeneuve NF, Lau A, Zhang DD.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1699-712. PubMed ID: 20486766
    [Abstract] [Full Text] [Related]

  • 6. Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.
    Chen YT, Shi D, Yang D, Yan B.
    Biochem Pharmacol; 2012 Sep 15; 84(6):864-71. PubMed ID: 22776248
    [Abstract] [Full Text] [Related]

  • 7. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
    Zhang DD, Hannink M.
    Mol Cell Biol; 2003 Nov 15; 23(22):8137-51. PubMed ID: 14585973
    [Abstract] [Full Text] [Related]

  • 8. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
    Baird L, Dinkova-Kostova AT.
    Biochem Biophys Res Commun; 2013 Mar 29; 433(1):58-65. PubMed ID: 23454126
    [Abstract] [Full Text] [Related]

  • 9. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
    Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1713-48. PubMed ID: 20446772
    [Abstract] [Full Text] [Related]

  • 10. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
    Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.
    Mol Cell Biol; 2004 Aug 01; 24(16):7130-9. PubMed ID: 15282312
    [Abstract] [Full Text] [Related]

  • 11. Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
    Jeong WS, Keum YS, Chen C, Jain MR, Shen G, Kim JH, Li W, Kong AN.
    J Biochem Mol Biol; 2005 Mar 31; 38(2):167-76. PubMed ID: 15826493
    [Abstract] [Full Text] [Related]

  • 12. Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
    Su C, Zhang P, Song X, Shi Q, Fu J, Xia X, Bai H, Hu L, Xu D, Song E, Song Y.
    Chem Res Toxicol; 2015 Apr 20; 28(4):765-74. PubMed ID: 25742418
    [Abstract] [Full Text] [Related]

  • 13. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
    Eggler AL, Small E, Hannink M, Mesecar AD.
    Biochem J; 2009 Jul 29; 422(1):171-80. PubMed ID: 19489739
    [Abstract] [Full Text] [Related]

  • 14. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
    Furukawa M, Xiong Y.
    Mol Cell Biol; 2005 Jan 29; 25(1):162-71. PubMed ID: 15601839
    [Abstract] [Full Text] [Related]

  • 15. Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies.
    Hu L, Miao W, Loignon M, Kandouz M, Batist G.
    Cancer Chemother Pharmacol; 2010 Aug 29; 66(3):467-74. PubMed ID: 19940992
    [Abstract] [Full Text] [Related]

  • 16. Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.
    Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P.
    Top Curr Chem; 2013 Aug 29; 329():163-77. PubMed ID: 22752583
    [Abstract] [Full Text] [Related]

  • 17. SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.
    Darvekar SR, Elvenes J, Brenne HB, Johansen T, Sjøttem E.
    PLoS One; 2014 Aug 29; 9(1):e85262. PubMed ID: 24416372
    [Abstract] [Full Text] [Related]

  • 18. Keap1 eye on the target: chemoprevention of liver cancer.
    Yates MS, Kensler TW.
    Acta Pharmacol Sin; 2007 Sep 29; 28(9):1331-42. PubMed ID: 17723167
    [Abstract] [Full Text] [Related]

  • 19. Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.
    Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL.
    Biomed Res Int; 2014 Sep 29; 2014():159459. PubMed ID: 25114896
    [Abstract] [Full Text] [Related]

  • 20. Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates.
    Das BN, Kim YW, Keum YS.
    Oxid Med Cell Longev; 2013 Sep 29; 2013():839409. PubMed ID: 23781297
    [Abstract] [Full Text] [Related]

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