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Journal Abstract Search

142 related items for PubMed ID: 21795044

  • 1. Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors.
    Çakmak R, Durdagi S, Ekinci D, Sentürk M, Topal G.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5398-402. PubMed ID: 21795044
    [Abstract] [Full Text] [Related]

  • 2. Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold.
    Chen X, Yang Y, Ma B, Zhang S, He M, Gui D, Hussain S, Jing C, Zhu C, Yu Q, Liu Y.
    Eur J Med Chem; 2011 May 15; 46(5):1536-44. PubMed ID: 21367494
    [Abstract] [Full Text] [Related]

  • 3. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.
    Ashton KS, St Jean DJ, Poon SF, Lee MR, Allen JG, Zhang S, Lofgren JA, Zhang X, Fotsch C, Hungate R.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5191-6. PubMed ID: 21824779
    [Abstract] [Full Text] [Related]

  • 4. Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase.
    Lanfranchi DA, Belorgey D, Müller T, Vezin H, Lanzer M, Davioud-Charvet E.
    Org Biomol Chem; 2012 Jun 28; 10(24):4795-806. PubMed ID: 22618151
    [Abstract] [Full Text] [Related]

  • 5. In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates.
    Sentürk M, Talaz O, Ekinci D, Cavdar H, Küfrevioğlu OI.
    Bioorg Med Chem Lett; 2009 Jul 01; 19(13):3661-3. PubMed ID: 19447620
    [Abstract] [Full Text] [Related]

  • 6. Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.
    Chonan T, Tanaka H, Yamamoto D, Yashiro M, Oi T, Wakasugi D, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A.
    Bioorg Med Chem Lett; 2010 Jul 01; 20(13):3965-8. PubMed ID: 20537533
    [Abstract] [Full Text] [Related]

  • 7. Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.
    Matter H, Scheiper B, Steinhagen H, Böcskei Z, Fleury V, McCort G.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5487-92. PubMed ID: 21840215
    [Abstract] [Full Text] [Related]

  • 8. Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone.
    Möller G, Deluca D, Gege C, Rosinus A, Kowalik D, Peters O, Droescher P, Elger W, Adamski J, Hillisch A.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6740-4. PubMed ID: 19836949
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
    Khabnadideh S, Pez D, Musso A, Brun R, Pérez LM, González-Pacanowska D, Gilbert IH.
    Bioorg Med Chem; 2005 Apr 01; 13(7):2637-49. PubMed ID: 15755663
    [Abstract] [Full Text] [Related]

  • 10. Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
    Sarkis M, Tran DN, Kolb S, Miteva MA, Villoutreix BO, Garbay C, Braud E.
    Bioorg Med Chem Lett; 2012 Dec 15; 22(24):7345-50. PubMed ID: 23141909
    [Abstract] [Full Text] [Related]

  • 11. Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor.
    Sriram D, Yogeeswari P, Methuku S, Vyas DR, Senthilkumar P, Alvala M, Jeankumar VU.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5149-54. PubMed ID: 21840711
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases.
    Sink R, Kovac A, Tomasić T, Rupnik V, Boniface A, Bostock J, Chopra I, Blanot D, Masic LP, Gobec S, Zega A.
    ChemMedChem; 2008 Sep 15; 3(9):1362-70. PubMed ID: 18651694
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl)quinoxalines as PI3Kα inhibitors.
    Wu P, Su Y, Liu X, Zhang L, Ye Y, Xu J, Weng S, Li Y, Liu T, Huang S, Yang B, He Q, Hu Y.
    Eur J Med Chem; 2011 Nov 15; 46(11):5540-8. PubMed ID: 21945250
    [Abstract] [Full Text] [Related]

  • 14. Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
    Scheiper B, Matter H, Steinhagen H, Böcskei Z, Fleury V, McCort G.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5480-6. PubMed ID: 21840218
    [Abstract] [Full Text] [Related]

  • 15. Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists.
    Lippa B, Morris J, Corbett M, Kwan TA, Noe MC, Snow SL, Gant TG, Mangiaracina M, Coffey HA, Foster B, Knauth EA, Wessel MD.
    Bioorg Med Chem Lett; 2006 Jul 01; 16(13):3444-8. PubMed ID: 16632359
    [Abstract] [Full Text] [Related]

  • 16. Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.
    Li J, Zhang J, Chen J, Luo X, Zhu W, Shen J, Liu H, Shen X, Jiang H.
    J Comb Chem; 2006 Jul 01; 8(3):326-37. PubMed ID: 16677001
    [Abstract] [Full Text] [Related]

  • 17. Design of more potent squalene synthase inhibitors with multiple activities.
    Kourounakis AP, Matralis AN, Nikitakis A.
    Bioorg Med Chem; 2010 Nov 01; 18(21):7402-12. PubMed ID: 20888243
    [Abstract] [Full Text] [Related]

  • 18. Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.
    Kimura T, Hamada Y, Stochaj M, Ikari H, Nagamine A, Abdel-Rahman H, Igawa N, Hidaka K, Nguyen JT, Saito K, Hayashi Y, Kiso Y.
    Bioorg Med Chem Lett; 2006 May 01; 16(9):2380-6. PubMed ID: 16481167
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and structure elucidation of novel fused 1,2,4-triazine derivatives as potent inhibitors targeting CYP1A1 activity.
    El Massry AM, Asal AM, Khattab SN, Haiba NS, Awney HA, Helmy M, Langer V, Amer A.
    Bioorg Med Chem; 2012 Apr 15; 20(8):2624-37. PubMed ID: 22414679
    [Abstract] [Full Text] [Related]

  • 20. Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs.
    Bäck M, Johansson PO, Wångsell F, Thorstensson F, Kvarnström I, Ayesa S, Wähling H, Pelcman M, Jansson K, Lindström S, Wallberg H, Classon B, Rydergård C, Vrang L, Hamelink E, Hallberg A, Rosenquist S, Samuelsson B.
    Bioorg Med Chem; 2007 Nov 15; 15(22):7184-202. PubMed ID: 17845856
    [Abstract] [Full Text] [Related]

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