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Journal Abstract Search

503 related items for PubMed ID: 21812781

  • 1. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
    Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M.
    J Neurochem; 2011 Oct; 119(1):231-9. PubMed ID: 21812781
    [Abstract] [Full Text] [Related]

  • 2. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [Abstract] [Full Text] [Related]

  • 3. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 4. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.
    J Neurochem; 2006 Dec; 99(6):1555-63. PubMed ID: 17083447
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  • 5. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.
    J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
    [Abstract] [Full Text] [Related]

  • 6. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
    Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.
    J Neurosci Res; 2011 Jun; 89(6):822-32. PubMed ID: 21433051
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  • 10. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
    Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU.
    J Neurochem; 2009 Dec; 111(6):1369-82. PubMed ID: 19804379
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  • 11. beta-Secretase, APP and Abeta in Alzheimer's disease.
    Vassar R.
    Subcell Biochem; 2005 Dec; 38():79-103. PubMed ID: 15709474
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  • 13. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y, Maruyama K, Tanuma S, Kiso Y, Ishiura S.
    J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
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  • 15. Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.
    Volbracht C, Penzkofer S, Mansson D, Christensen KV, Fog K, Schildknecht S, Leist M, Nielsen J.
    Anal Biochem; 2009 Apr 15; 387(2):208-20. PubMed ID: 19454261
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  • 16. Immunomodulation of AβPP processing alleviates amyloid-β-related pathology in Alzheimer's disease transgenic mice.
    Arbel-Ornath M, Becker M, Rabinovich-Toidman P, Gartner M, Solomon B.
    J Alzheimers Dis; 2010 Apr 15; 22(2):469-82. PubMed ID: 20847413
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  • 19. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P, Feyt C, Huysseune S, de Diesbach P, N'Kuli F, Courtoy PJ, Octave JN.
    J Neurosci Res; 2006 Nov 01; 84(6):1311-22. PubMed ID: 16941495
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