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Journal Abstract Search

360 related items for PubMed ID: 21823662

  • 1. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria.
    Xie J, Pierce JG, James RC, Okano A, Boger DL.
    J Am Chem Soc; 2011 Sep 07; 133(35):13946-9. PubMed ID: 21823662
    [Abstract] [Full Text] [Related]

  • 2. Total synthesis of [Ψ[C(═S)NH]Tpg4]vancomycin aglycon, [Ψ[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.
    Xie J, Okano A, Pierce JG, James RC, Stamm S, Crane CM, Boger DL.
    J Am Chem Soc; 2012 Jan 18; 134(2):1284-97. PubMed ID: 22188323
    [Abstract] [Full Text] [Related]

  • 3. Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics.
    Okano A, Nakayama A, Wu K, Lindsey EA, Schammel AW, Feng Y, Collins KC, Boger DL.
    J Am Chem Soc; 2015 Mar 18; 137(10):3693-704. PubMed ID: 25750995
    [Abstract] [Full Text] [Related]

  • 4. Total synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.
    Crowley BM, Boger DL.
    J Am Chem Soc; 2006 Mar 08; 128(9):2885-92. PubMed ID: 16506767
    [Abstract] [Full Text] [Related]

  • 5. Maxamycins: Durable Antibiotics Derived by Rational Redesign of Vancomycin.
    Wu ZC, Boger DL.
    Acc Chem Res; 2020 Nov 17; 53(11):2587-2599. PubMed ID: 33138354
    [Abstract] [Full Text] [Related]

  • 6. Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics.
    Okano A, Isley NA, Boger DL.
    Proc Natl Acad Sci U S A; 2017 Jun 27; 114(26):E5052-E5061. PubMed ID: 28559345
    [Abstract] [Full Text] [Related]

  • 7. Binding of a dimeric derivative of vancomycin to L-Lys-D-Ala-D-lactate in solution and at a surface.
    Rao J, Yan L, Lahiri J, Whitesides GM, Weis RM, Warren HS.
    Chem Biol; 1999 Jun 27; 6(6):353-9. PubMed ID: 10375541
    [Abstract] [Full Text] [Related]

  • 8. Total synthesis of [Ψ[C(═NH)NH]Tpg(4)]vancomycin and its (4-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding.
    Okano A, Nakayama A, Schammel AW, Boger DL.
    J Am Chem Soc; 2014 Oct 01; 136(39):13522-5. PubMed ID: 25211770
    [Abstract] [Full Text] [Related]

  • 9. Quantification of the d-Ala-d-Lac-Terminated Peptidoglycan Structure in Vancomycin-Resistant Enterococcus faecalis Using a Combined Solid-State Nuclear Magnetic Resonance and Mass Spectrometry Analysis.
    Chang JD, Foster EE, Yang H, Kim SJ.
    Biochemistry; 2017 Jan 31; 56(4):612-622. PubMed ID: 28040891
    [Abstract] [Full Text] [Related]

  • 10. First principles investigation of vancomycin and teicoplanin binding to bacterial cell wall termini.
    Lee JG, Sagui C, Roland C.
    J Am Chem Soc; 2004 Jul 14; 126(27):8384-5. PubMed ID: 15237988
    [Abstract] [Full Text] [Related]

  • 11. In vivo studies suggest that induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall.
    Kwun MJ, Novotna G, Hesketh AR, Hill L, Hong HJ.
    Antimicrob Agents Chemother; 2013 Sep 14; 57(9):4470-80. PubMed ID: 23836175
    [Abstract] [Full Text] [Related]

  • 12. Substrate Inhibition of VanA by d-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner.
    van der Aart LT, Lemmens N, van Wamel WJ, van Wezel GP.
    Antimicrob Agents Chemother; 2016 Aug 14; 60(8):4930-9. PubMed ID: 27270282
    [Abstract] [Full Text] [Related]

  • 13. Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria.
    Zarkan A, Macklyne HR, Chirgadze DY, Bond AD, Hesketh AR, Hong HJ.
    Sci Rep; 2017 Jul 07; 7(1):4893. PubMed ID: 28687742
    [Abstract] [Full Text] [Related]

  • 14. Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.
    Ge M, Chen Z, Onishi HR, Kohler J, Silver LL, Kerns R, Fukuzawa S, Thompson C, Kahne D.
    Science; 1999 Apr 16; 284(5413):507-11. PubMed ID: 10205063
    [Abstract] [Full Text] [Related]

  • 15. Determinants for differential effects on D-Ala-D-lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci.
    Lessard IA, Healy VL, Park IS, Walsh CT.
    Biochemistry; 1999 Oct 19; 38(42):14006-22. PubMed ID: 10529248
    [Abstract] [Full Text] [Related]

  • 16. Quantum simulations of the structure and binding of glycopeptide antibiotic aglycons to cell wall analogues.
    Lee JG, Sagui C, Roland C.
    J Phys Chem B; 2005 Nov 03; 109(43):20588-96. PubMed ID: 16853665
    [Abstract] [Full Text] [Related]

  • 17. Characterization of structural variations in the peptidoglycan of vancomycin-susceptible Enterococcus faecium: understanding glycopeptide-antibiotic binding sites using mass spectrometry.
    Patti GJ, Chen J, Schaefer J, Gross ML.
    J Am Soc Mass Spectrom; 2008 Oct 03; 19(10):1467-75. PubMed ID: 18692403
    [Abstract] [Full Text] [Related]

  • 18. Affinity adsorbents for the vancomycin group of antibiotics.
    Yan H, Zhao Q, Yuan J, Cheng X, He B.
    Biotechnol Appl Biochem; 2000 Feb 03; 31(1):15-20. PubMed ID: 10669398
    [Abstract] [Full Text] [Related]

  • 19. Semiquantitation of cooperativity in binding of vancomycin-group antibiotics to vancomycin-susceptible and -resistant organisms.
    Beauregard DA, Maguire AJ, Williams DH, Reynolds PE.
    Antimicrob Agents Chemother; 1997 Nov 03; 41(11):2418-23. PubMed ID: 9371343
    [Abstract] [Full Text] [Related]

  • 20. Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.
    Yarlagadda V, Konai MM, Manjunath GB, Ghosh C, Haldar J.
    J Antibiot (Tokyo); 2015 May 03; 68(5):302-12. PubMed ID: 25351946
    [Abstract] [Full Text] [Related]

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