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Journal Abstract Search

293 related items for PubMed ID: 21831637

  • 1. Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
    Li X, Hilgers M, Cunningham M, Chen Z, Trzoss M, Zhang J, Kohnen L, Lam T, Creighton C, G C K, Nelson K, Kwan B, Stidham M, Brown-Driver V, Shaw KJ, Finn J.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5171-6. PubMed ID: 21831637
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  • 2. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.
    Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE.
    J Antimicrob Chemother; 2009 Apr 15; 63(4):687-98. PubMed ID: 19211577
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  • 3. Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
    Lam T, Hilgers MT, Cunningham ML, Kwan BP, Nelson KJ, Brown-Driver V, Ong V, Trzoss M, Hough G, Shaw KJ, Finn J.
    J Med Chem; 2014 Feb 13; 57(3):651-68. PubMed ID: 24428639
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  • 4. Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.
    Wyss PC, Gerber P, Hartman PG, Hubschwerlen C, Locher H, Marty HP, Stahl M.
    J Med Chem; 2003 Jun 05; 46(12):2304-12. PubMed ID: 12773035
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  • 5. Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
    Khabnadideh S, Pez D, Musso A, Brun R, Pérez LM, González-Pacanowska D, Gilbert IH.
    Bioorg Med Chem; 2005 Apr 01; 13(7):2637-49. PubMed ID: 15755663
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  • 6. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus.
    Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE.
    Acta Crystallogr D Biol Crystallogr; 2009 Aug 01; 65(Pt 8):751-7. PubMed ID: 19622858
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  • 10. Dihydrofolate reductase inhibitors as antibacterial agents.
    Hawser S, Lociuro S, Islam K.
    Biochem Pharmacol; 2006 Mar 30; 71(7):941-8. PubMed ID: 16359642
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  • 11. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
    Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R, Galitsky N, Luft JR, Pangborn W.
    J Med Chem; 1998 Aug 27; 41(18):3426-34. PubMed ID: 9719595
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  • 14. Synthesis and biological activity of novel antibacterial quinazolines.
    Bedi PM, Kumar V, Mahajan MP.
    Bioorg Med Chem Lett; 2004 Oct 18; 14(20):5211-3. PubMed ID: 15380229
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  • 17. Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis.
    Gomez L, Hack MD, Wu J, Wiener JJ, Venkatesan H, Santillán A, Pippel DJ, Mani N, Morrow BJ, Motley ST, Shaw KJ, Wolin R, Grice CA, Jones TK.
    Bioorg Med Chem Lett; 2007 May 15; 17(10):2723-7. PubMed ID: 17368897
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