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225 related items for PubMed ID: 21837756

  • 1. In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways.
    Wu TY, Saw CL, Khor TO, Pung D, Boyanapalli SS, Kong AN.
    Mol Carcinog; 2012 Oct; 51(10):761-70. PubMed ID: 21837756
    [Abstract] [Full Text] [Related]

  • 2. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.
    Saw CL, Cintrón M, Wu TY, Guo Y, Huang Y, Jeong WS, Kong AN.
    Biopharm Drug Dispos; 2011 Jul; 32(5):289-300. PubMed ID: 21656528
    [Abstract] [Full Text] [Related]

  • 3. A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.
    Huang Y, Khor TO, Shu L, Saw CL, Wu TY, Suh N, Yang CS, Kong AN.
    J Nutr; 2012 May; 142(5):818-23. PubMed ID: 22457388
    [Abstract] [Full Text] [Related]

  • 4. Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.
    Wu TY, Khor TO, Su ZY, Saw CL, Shu L, Cheung KL, Huang Y, Yu S, Kong AN.
    AAPS J; 2013 Jul; 15(3):864-74. PubMed ID: 23658110
    [Abstract] [Full Text] [Related]

  • 5. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
    Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.
    Oncogene; 2001 May 24; 20(23):2927-36. PubMed ID: 11420705
    [Abstract] [Full Text] [Related]

  • 6. Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation.
    Khor TO, Huang Y, Wu TY, Shu L, Lee J, Kong AN.
    Biochem Pharmacol; 2011 Nov 01; 82(9):1073-8. PubMed ID: 21787756
    [Abstract] [Full Text] [Related]

  • 7. Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.
    Zhang C, Su ZY, Khor TO, Shu L, Kong AN.
    Biochem Pharmacol; 2013 May 01; 85(9):1398-404. PubMed ID: 23416117
    [Abstract] [Full Text] [Related]

  • 8. Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.
    Li W, Pung D, Su ZY, Guo Y, Zhang C, Yang AY, Zheng X, Du ZY, Zhang K, Kong AN.
    Chem Res Toxicol; 2016 Apr 18; 29(4):694-703. PubMed ID: 26991801
    [Abstract] [Full Text] [Related]

  • 9. Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway.
    Hajra S, Patra AR, Basu A, Saha P, Bhattacharya S.
    Chem Biol Interact; 2018 Jun 25; 290():19-36. PubMed ID: 29775573
    [Abstract] [Full Text] [Related]

  • 10. Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.
    Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF, Firestone GL.
    Biochem Pharmacol; 2006 Dec 15; 72(12):1714-23. PubMed ID: 16970927
    [Abstract] [Full Text] [Related]

  • 11. Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model.
    Gupta S, Adhami VM, Subbarayan M, MacLennan GT, Lewin JS, Hafeli UO, Fu P, Mukhtar H.
    Cancer Res; 2004 May 01; 64(9):3334-43. PubMed ID: 15126378
    [Abstract] [Full Text] [Related]

  • 12. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
    Hsu JC, Zhang J, Dev A, Wing A, Bjeldanes LF, Firestone GL.
    Carcinogenesis; 2005 Nov 01; 26(11):1896-904. PubMed ID: 15958518
    [Abstract] [Full Text] [Related]

  • 13. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.
    Keum YS, Khor TO, Lin W, Shen G, Kwon KH, Barve A, Li W, Kong AN.
    Pharm Res; 2009 Oct 01; 26(10):2324-31. PubMed ID: 19669099
    [Abstract] [Full Text] [Related]

  • 14. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells.
    Zhang J, Hsu B A JC, Kinseth B A MA, Bjeldanes LF, Firestone GL.
    Cancer; 2003 Dec 01; 98(11):2511-20. PubMed ID: 14635088
    [Abstract] [Full Text] [Related]

  • 15. Nrf2 sensitizes prostate cancer cells to radiation via decreasing basal ROS levels.
    Liu M, Yao XD, Li W, Geng J, Yan Y, Che JP, Xu YF, Zheng JH.
    Biofactors; 2015 Dec 01; 41(1):52-7. PubMed ID: 25728635
    [Abstract] [Full Text] [Related]

  • 16. Indole-3-carbinol induces tumor cell death: function follows form.
    Megna BW, Carney PR, Nukaya M, Geiger P, Kennedy GD.
    J Surg Res; 2016 Jul 01; 204(1):47-54. PubMed ID: 27451867
    [Abstract] [Full Text] [Related]

  • 17. Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway.
    Lin H, Gao X, Chen G, Sun J, Chu J, Jing K, Li P, Zeng R, Wei B.
    Biochem Biophys Res Commun; 2015 May 01; 460(2):422-7. PubMed ID: 25795137
    [Abstract] [Full Text] [Related]

  • 18. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
    McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD.
    Cancer Res; 2001 Apr 15; 61(8):3299-307. PubMed ID: 11309284
    [Abstract] [Full Text] [Related]

  • 19. Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation.
    Hu H, Li F, Zhu F, Li J, Wang S, He Z, Chen J, Cheng L, Zhong F.
    Biochem Pharmacol; 2024 May 15; 223():116193. PubMed ID: 38582268
    [Abstract] [Full Text] [Related]

  • 20. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium.
    Chen DZ, Qi M, Auborn KJ, Carter TH.
    J Nutr; 2001 Dec 15; 131(12):3294-302. PubMed ID: 11739883
    [Abstract] [Full Text] [Related]

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