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Journal Abstract Search

227 related items for PubMed ID: 21856153

  • 21. Aryloxy phosphoramidate triesters as pro-tides.
    Cahard D, McGuigan C, Balzarini J.
    Mini Rev Med Chem; 2004 May; 4(4):371-81. PubMed ID: 15134540
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  • 22. Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
    Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.
    Antivir Chem Chemother; 2009 Oct 19; 20(2):99-106. PubMed ID: 19843980
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  • 23. Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication.
    Zhu R, Wang M, Xia Y, Qu F, Neyts J, Peng L.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3321-7. PubMed ID: 18445526
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  • 24. Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
    Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU.
    Bioorg Med Chem Lett; 2015 Mar 01; 25(5):1040-3. PubMed ID: 25650256
    [Abstract] [Full Text] [Related]

  • 25. The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
    Smith DB, Kalayanov G, Sund C, Winqvist A, Pinho P, Maltseva T, Morisson V, Leveque V, Rajyaguru S, Le Pogam S, Najera I, Benkestock K, Zhou XX, Maag H, Cammack N, Martin JA, Swallow S, Johansson NG, Klumpp K, Smith M.
    J Med Chem; 2009 Jan 08; 52(1):219-23. PubMed ID: 19055482
    [Abstract] [Full Text] [Related]

  • 26. First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
    Perrone P, Daverio F, Valente R, Rajyaguru S, Martin JA, Lévêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C.
    J Med Chem; 2007 Nov 01; 50(22):5463-70. PubMed ID: 17914786
    [Abstract] [Full Text] [Related]

  • 27. Stereoselective synthesis of PSI-352938: a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV.
    Reddy PG, Chun BK, Zhang HR, Rachakonda S, Ross BS, Sofia MJ.
    J Org Chem; 2011 May 20; 76(10):3782-90. PubMed ID: 21469736
    [Abstract] [Full Text] [Related]

  • 28. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
    Shi J, Zhou L, Zhang H, McBrayer TR, Detorio MA, Johns M, Bassit L, Powdrill MH, Whitaker T, Coats SJ, Götte M, Schinazi RF.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7094-8. PubMed ID: 22014549
    [Abstract] [Full Text] [Related]

  • 29. Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.
    McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, Jones S, Kolykhalov A, Bleiman B, Bryant KD, Ganguly B, Gorovits E, Henson G, Hunley D, Hutchins J, Muhammad J, Obikhod A, Patti J, Walters CR, Wang J, Vernachio J, Ramamurty CV, Battina SK, Chamberlain S.
    J Med Chem; 2011 Dec 22; 54(24):8632-45. PubMed ID: 22039920
    [Abstract] [Full Text] [Related]

  • 30. Synthesis and biological activity of bimorpholine and its carbanucleoside.
    Ausmees K, Selyutina A, Kütt K, Lippur K, Pehk T, Lopp M, Zusinaite E, Merits A, Kanger T.
    Nucleosides Nucleotides Nucleic Acids; 2011 Nov 22; 30(11):897-907. PubMed ID: 22060554
    [Abstract] [Full Text] [Related]

  • 31. Synthesis of 9-(2-beta-C-methyl-beta-d-ribofuranosyl)-6-substituted purine derivatives as inhibitors of HCV RNA replication.
    Ding Y, Girardet JL, Hong Z, Lai VC, An H, Koh YH, Shaw SZ, Zhong W.
    Bioorg Med Chem Lett; 2005 Feb 01; 15(3):709-13. PubMed ID: 15664842
    [Abstract] [Full Text] [Related]

  • 32. Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine.
    Meppen M, Pacini B, Bazzo R, Koch U, Leone JF, Koeplinger KA, Rowley M, Altamura S, Di Marco A, Fiore F, Giuliano C, Gonzalez-Paz O, Laufer R, Pucci V, Narjes F, Gardelli C.
    Eur J Med Chem; 2009 Sep 01; 44(9):3765-70. PubMed ID: 19493593
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  • 33. QSAR models for phosphoramidate prodrugs of 2'-methylcytidine as inhibitors of hepatitis C virus based on PSO boosting.
    Cheng Z, Zhang Y, Zhou C.
    Chem Biol Drug Des; 2011 Dec 01; 78(6):948-59. PubMed ID: 21895985
    [Abstract] [Full Text] [Related]

  • 34. Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.
    Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.
    J Med Chem; 2005 Aug 25; 48(17):5504-8. PubMed ID: 16107149
    [Abstract] [Full Text] [Related]

  • 35. β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
    Zhou L, Zhang HW, Tao S, Bassit L, Whitaker T, McBrayer TR, Ehteshami M, Amiralaei S, Pradere U, Cho JH, Amblard F, Bobeck D, Detorio M, Coats SJ, Schinazi RF.
    J Med Chem; 2015 Apr 23; 58(8):3445-58. PubMed ID: 25849312
    [Abstract] [Full Text] [Related]

  • 36. INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
    Vernachio JH, Bleiman B, Bryant KD, Chamberlain S, Hunley D, Hutchins J, Ames B, Gorovits E, Ganguly B, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters CR, Wang J, Williams K, Patti JM, Henson G, Madela K, Aljarah M, Gilles A, McGuigan C.
    Antimicrob Agents Chemother; 2011 May 23; 55(5):1843-51. PubMed ID: 21357300
    [Abstract] [Full Text] [Related]

  • 37. Synthesis of 5'-methylene-phosphonate furanonucleoside prodrugs: application to D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl nucleosides.
    Pradere U, Amblard F, Coats SJ, Schinazi RF.
    Org Lett; 2012 Sep 07; 14(17):4426-9. PubMed ID: 22917194
    [Abstract] [Full Text] [Related]

  • 38. Phosphoramidate protides of 2',3'-dideoxy-3'-fluoroadenosine and related nucleosides with potent activity against HIV and HBV.
    Gudmundsson KS, Daluge SM, Johnson LC, Jansen R, Hazen R, Condreay LD, McGuigan C.
    Nucleosides Nucleotides Nucleic Acids; 2003 Oct 07; 22(10):1953-61. PubMed ID: 14609234
    [Abstract] [Full Text] [Related]

  • 39. Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.
    Liang Y, Narayanasamy J, Schinazi RF, Chu CK.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2178-89. PubMed ID: 16314108
    [Abstract] [Full Text] [Related]

  • 40. Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.
    Gudmundsson KS, Wang Z, Daluge SM, Johnson LC, Hazen R, Condreay LD, McGuigan C.
    Nucleosides Nucleotides Nucleic Acids; 2004 Apr 01; 23(12):1929-37. PubMed ID: 15628749
    [Abstract] [Full Text] [Related]

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