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358 related items for PubMed ID: 21868452

  • 1. Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.
    Coopman K, Wallis R, Robb G, Brown AJ, Wilkinson GF, Timms D, Willars GB.
    Mol Endocrinol; 2011 Oct; 25(10):1804-18. PubMed ID: 21868452
    [Abstract] [Full Text] [Related]

  • 2. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.
    Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R.
    J Biol Chem; 2008 Apr 25; 283(17):11340-7. PubMed ID: 18287102
    [Abstract] [Full Text] [Related]

  • 3. The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1.
    López de Maturana R, Willshaw A, Kuntzsch A, Rudolph R, Donnelly D.
    J Biol Chem; 2003 Mar 21; 278(12):10195-200. PubMed ID: 12524435
    [Abstract] [Full Text] [Related]

  • 4. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.
    Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S.
    J Biol Chem; 2010 Jan 01; 285(1):723-30. PubMed ID: 19861722
    [Abstract] [Full Text] [Related]

  • 5. Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.
    Runge S, Schimmer S, Oschmann J, Schiødt CB, Knudsen SM, Jeppesen CB, Madsen K, Lau J, Thøgersen H, Rudolph R.
    Biochemistry; 2007 May 15; 46(19):5830-40. PubMed ID: 17444618
    [Abstract] [Full Text] [Related]

  • 6. A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors.
    Al-Sabah S, Donnelly D.
    Br J Pharmacol; 2003 Sep 15; 140(2):339-46. PubMed ID: 12970080
    [Abstract] [Full Text] [Related]

  • 7. The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.
    Mann RJ, Nasr NE, Sinfield JK, Paci E, Donnelly D.
    Br J Pharmacol; 2010 Aug 15; 160(8):1973-84. PubMed ID: 20649595
    [Abstract] [Full Text] [Related]

  • 8. Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain.
    West GM, Willard FS, Sloop KW, Showalter AD, Pascal BD, Griffin PR.
    PLoS One; 2014 Aug 15; 9(9):e105683. PubMed ID: 25180755
    [Abstract] [Full Text] [Related]

  • 9. Characterization of glucagon-like peptide-1 receptor-binding determinants.
    Xiao Q, Jeng W, Wheeler MB.
    J Mol Endocrinol; 2000 Dec 15; 25(3):321-35. PubMed ID: 11116211
    [Abstract] [Full Text] [Related]

  • 10. Transmembrane α-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor.
    Rye Underwood C, Møller Knudsen S, Schjellerup Wulff B, Bräuner-Osborne H, Lau J, Knudsen LB, Peters GH, Reedtz-Runge S.
    Pharmacology; 2011 Dec 15; 88(5-6):340-8. PubMed ID: 22134089
    [Abstract] [Full Text] [Related]

  • 11. High potency antagonists of the pancreatic glucagon-like peptide-1 receptor.
    Montrose-Rafizadeh C, Yang H, Rodgers BD, Beday A, Pritchette LA, Eng J.
    J Biol Chem; 1997 Aug 22; 272(34):21201-6. PubMed ID: 9261127
    [Abstract] [Full Text] [Related]

  • 12. Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.
    Moon MJ, Lee YN, Park S, Reyes-Alcaraz A, Hwang JI, Millar RP, Choe H, Seong JY.
    J Biol Chem; 2015 Feb 27; 290(9):5696-706. PubMed ID: 25561730
    [Abstract] [Full Text] [Related]

  • 13. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
    Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.
    J Biol Chem; 2012 Feb 03; 287(6):3642-58. PubMed ID: 22147710
    [Abstract] [Full Text] [Related]

  • 14. The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.
    Graziano MP, Hey PJ, Strader CD.
    Recept Channels; 1996 Feb 03; 4(1):9-17. PubMed ID: 8723643
    [Abstract] [Full Text] [Related]

  • 15. Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R).
    Koole C, Reynolds CA, Mobarec JC, Hick C, Sexton PM, Sakmar TP.
    J Biol Chem; 2017 Apr 28; 292(17):7131-7144. PubMed ID: 28283573
    [Abstract] [Full Text] [Related]

  • 16. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.
    Estall JL, Koehler JA, Yusta B, Drucker DJ.
    J Biol Chem; 2005 Jun 10; 280(23):22124-34. PubMed ID: 15817468
    [Abstract] [Full Text] [Related]

  • 17. Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues.
    López de Maturana R, Treece-Birch J, Abidi F, Findlay JB, Donnelly D.
    Protein Pept Lett; 2004 Feb 10; 11(1):15-22. PubMed ID: 14965274
    [Abstract] [Full Text] [Related]

  • 18. Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).
    Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW.
    J Biol Chem; 2016 Jun 17; 291(25):12991-3004. PubMed ID: 27059958
    [Abstract] [Full Text] [Related]

  • 19. Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.
    Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE.
    J Biol Chem; 2016 Jul 15; 291(29):15119-30. PubMed ID: 27226600
    [Abstract] [Full Text] [Related]

  • 20. The primary ligand-binding interaction at the GLP-1 receptor is via the putative helix of the peptide agonists.
    Al-Sabah S, Donnelly D.
    Protein Pept Lett; 2004 Feb 15; 11(1):9-14. PubMed ID: 14965273
    [Abstract] [Full Text] [Related]

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