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358 related items for PubMed ID: 21868452

  • 21. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
    Koole C, Wootten D, Simms J, Savage EE, Miller LJ, Christopoulos A, Sexton PM.
    J Biol Chem; 2012 Feb 03; 287(6):3659-73. PubMed ID: 22147709
    [Abstract] [Full Text] [Related]

  • 22. Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.
    Runge S, Gram C, Brauner-Osborne H, Madsen K, Knudsen LB, Wulff BS.
    J Biol Chem; 2003 Jul 25; 278(30):28005-10. PubMed ID: 12724331
    [Abstract] [Full Text] [Related]

  • 23. Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
    Swedberg JE, Schroeder CI, Mitchell JM, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Price DA, Liras S, Craik DJ.
    J Biol Chem; 2016 Jul 22; 291(30):15778-87. PubMed ID: 27226591
    [Abstract] [Full Text] [Related]

  • 24. Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity.
    Runge S, Wulff BS, Madsen K, Bräuner-Osborne H, Knudsen LB.
    Br J Pharmacol; 2003 Mar 22; 138(5):787-94. PubMed ID: 12642379
    [Abstract] [Full Text] [Related]

  • 25. Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation.
    Moon MJ, Kim HY, Park S, Kim DK, Cho EB, Park CR, You DJ, Hwang JI, Kim K, Choe H, Seong JY.
    J Biol Chem; 2012 Feb 03; 287(6):3873-84. PubMed ID: 22105074
    [Abstract] [Full Text] [Related]

  • 26. A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness.
    Beinborn M, Worrall CI, McBride EW, Kopin AS.
    Regul Pept; 2005 Aug 15; 130(1-2):1-6. PubMed ID: 15975668
    [Abstract] [Full Text] [Related]

  • 27. Five out of six tryptophan residues in the N-terminal extracellular domain of the rat GLP-1 receptor are essential for its ability to bind GLP-1.
    Wilmen A, Van Eyll B, Göke B, Göke R.
    Peptides; 1997 Aug 15; 18(2):301-5. PubMed ID: 9149304
    [Abstract] [Full Text] [Related]

  • 28. The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists.
    Al-Sabah S, Donnelly D.
    FEBS Lett; 2003 Oct 23; 553(3):342-6. PubMed ID: 14572647
    [Abstract] [Full Text] [Related]

  • 29. Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.
    Mann RJ, Al-Sabah S, de Maturana RL, Sinfield JK, Donnelly D.
    Peptides; 2010 Dec 23; 31(12):2289-93. PubMed ID: 20869417
    [Abstract] [Full Text] [Related]

  • 30. Isolation and structure-function studies of a glucagon-like peptide 1 receptor from goldfish Carassius auratus: identification of three charged residues in extracellular domains critical for receptor function.
    Yeung CM, Mojsov S, Mok PY, Chow BK.
    Endocrinology; 2002 Dec 23; 143(12):4646-54. PubMed ID: 12446592
    [Abstract] [Full Text] [Related]

  • 31. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.
    Baggio LL, Huang Q, Brown TJ, Drucker DJ.
    Gastroenterology; 2004 Aug 23; 127(2):546-58. PubMed ID: 15300587
    [Abstract] [Full Text] [Related]

  • 32. Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors.
    Moon MJ, Kim HY, Kim SG, Park J, Choi DS, Hwang JI, Seong JY.
    Mol Cells; 2010 Aug 23; 30(2):149-54. PubMed ID: 20799012
    [Abstract] [Full Text] [Related]

  • 33. The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling.
    Dods RL, Donnelly D.
    Biosci Rep; 2015 Nov 23; 36(1):e00285. PubMed ID: 26598711
    [Abstract] [Full Text] [Related]

  • 34. Exchange of W39 by A within the N-terminal extracellular domain of the GLP-1 receptor results in a loss of receptor function.
    Van Eyll B, Göke B, Wilmen A, Göke R.
    Peptides; 1996 Nov 23; 17(4):565-70. PubMed ID: 8804062
    [Abstract] [Full Text] [Related]

  • 35. Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
    Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.
    J Pharmacol Exp Ther; 2015 Apr 23; 353(1):52-63. PubMed ID: 25630467
    [Abstract] [Full Text] [Related]

  • 36. Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.
    Chepurny OG, Matsoukas MT, Liapakis G, Leech CA, Milliken BT, Doyle RP, Holz GG.
    J Biol Chem; 2019 Mar 08; 294(10):3514-3531. PubMed ID: 30622136
    [Abstract] [Full Text] [Related]

  • 37. Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor.
    Kirkpatrick A, Heo J, Abrol R, Goddard WA.
    Proc Natl Acad Sci U S A; 2012 Dec 04; 109(49):19988-93. PubMed ID: 23169631
    [Abstract] [Full Text] [Related]

  • 38. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.
    Göke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Göke B.
    J Biol Chem; 1993 Sep 15; 268(26):19650-5. PubMed ID: 8396143
    [Abstract] [Full Text] [Related]

  • 39. Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor.
    Gelling RW, Wheeler MB, Xue J, Gyomorey S, Nian C, Pederson RA, McIntosh CH.
    Endocrinology; 1997 Jun 15; 138(6):2640-3. PubMed ID: 9165060
    [Abstract] [Full Text] [Related]

  • 40. Exendin-4 and glucagon-like-peptide-1: NMR structural comparisons in the solution and micelle-associated states.
    Neidigh JW, Fesinmeyer RM, Prickett KS, Andersen NH.
    Biochemistry; 2001 Nov 06; 40(44):13188-200. PubMed ID: 11683627
    [Abstract] [Full Text] [Related]

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