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1698 related items for PubMed ID: 21883446

  • 1. Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.
    Babizhayev MA.
    Fundam Clin Pharmacol; 2012 Feb; 26(1):86-117. PubMed ID: 21883446
    [Abstract] [Full Text] [Related]

  • 2. Senescent phenotype of trabecular meshwork cells displays biomarkers in primary open-angle glaucoma.
    Babizhayev MA, Yegorov YE.
    Curr Mol Med; 2011 Oct; 11(7):528-52. PubMed ID: 21707516
    [Abstract] [Full Text] [Related]

  • 3. N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients.
    Babizhayev MA, Micans P, Guiotto A, Kasus-Jacobi A.
    Am J Ther; 2009 Oct; 16(6):517-33. PubMed ID: 19487926
    [Abstract] [Full Text] [Related]

  • 4. Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.
    Babizhayev MA.
    Cell Biochem Funct; 2011 Apr; 29(3):183-206. PubMed ID: 21381059
    [Abstract] [Full Text] [Related]

  • 5. State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
    Babizhayev MA, Kasus-Jacobi A.
    Curr Clin Pharmacol; 2009 Jan; 4(1):4-37. PubMed ID: 19149498
    [Abstract] [Full Text] [Related]

  • 6. [Oxidative stress in the trabecular meshwork of POAG].
    Welge-Lüssen U, Birke K.
    Klin Monbl Augenheilkd; 2010 Feb; 227(2):99-107. PubMed ID: 20155653
    [Abstract] [Full Text] [Related]

  • 7. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.
    Babizhayev MA.
    Drug Metabol Drug Interact; 2009 Feb; 24(2-4):275-323. PubMed ID: 20408504
    [Abstract] [Full Text] [Related]

  • 8. Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues.
    Yu AL, Fuchshofer R, Kampik A, Welge-Lüssen U.
    Invest Ophthalmol Vis Sci; 2008 Nov; 49(11):4872-80. PubMed ID: 18971427
    [Abstract] [Full Text] [Related]

  • 9. Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.
    Babizhayev MA.
    Drugs R D; 2005 Nov; 6(6):345-69. PubMed ID: 16274259
    [Abstract] [Full Text] [Related]

  • 10. [The progress of aqueous humor outflow pathway in open-angle glaucoma].
    An L, Ji J.
    Zhonghua Yan Ke Za Zhi; 2011 Oct; 47(10):953-6. PubMed ID: 22321508
    [Abstract] [Full Text] [Related]

  • 11. Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
    Babizhayev MA, Yegorov YE.
    Recent Pat Drug Deliv Formul; 2016 Oct; 10(2):82-129. PubMed ID: 26084629
    [Abstract] [Full Text] [Related]

  • 12. N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.
    Babizhayev MA, Burke L, Micans P, Richer SP.
    Clin Interv Aging; 2009 Oct; 4():31-50. PubMed ID: 19503764
    [Abstract] [Full Text] [Related]

  • 13. New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans.
    Babizhayev MA.
    Am J Ther; 2010 Oct; 17(4):373-89. PubMed ID: 20463577
    [Abstract] [Full Text] [Related]

  • 14. Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.
    Wordinger RJ, Fleenor DL, Hellberg PE, Pang IH, Tovar TO, Zode GS, Fuller JA, Clark AF.
    Invest Ophthalmol Vis Sci; 2007 Mar; 48(3):1191-200. PubMed ID: 17325163
    [Abstract] [Full Text] [Related]

  • 15. Structural changes of the trabecular meshwork in different kinds of glaucoma.
    Tektas OY, Lütjen-Drecoll E.
    Exp Eye Res; 2009 Apr; 88(4):769-75. PubMed ID: 19114037
    [Abstract] [Full Text] [Related]

  • 16. Biomarkers of oxidative stress and cataract. Novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: anti-cataract which helps to prevent and treat cataracts in the eyes of dogs and other animals.
    Babizhayev MA, Yegorov YE.
    Curr Drug Deliv; 2014 Apr; 11(1):24-61. PubMed ID: 24783234
    [Abstract] [Full Text] [Related]

  • 17. Trabecular meshwork as a new target for the treatment of glaucoma.
    Ferrer E.
    Drug News Perspect; 2006 Apr; 19(3):151-8. PubMed ID: 16804567
    [Abstract] [Full Text] [Related]

  • 18. Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform.
    Babizhayev MA.
    Drug Test Anal; 2012 Jun; 4(6):468-85. PubMed ID: 21416634
    [Abstract] [Full Text] [Related]

  • 19. Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.
    He Y, Leung KW, Zhang YH, Duan S, Zhong XF, Jiang RZ, Peng Z, Tombran-Tink J, Ge J.
    Invest Ophthalmol Vis Sci; 2008 Apr; 49(4):1447-58. PubMed ID: 18385062
    [Abstract] [Full Text] [Related]

  • 20. Lipid peroxidation in open-angle glaucoma.
    Babizhayev MA, Bunin AYa.
    Acta Ophthalmol (Copenh); 1989 Aug; 67(4):371-7. PubMed ID: 2801038
    [Abstract] [Full Text] [Related]

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