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Journal Abstract Search

229 related items for PubMed ID: 21884709

  • 21. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.
    Gerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, Atienzar FA.
    Cell Biol Toxicol; 2012 Apr; 28(2):69-87. PubMed ID: 22258563
    [Abstract] [Full Text] [Related]

  • 22. Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening.
    Gómez-Lechón MJ, Tolosa L.
    Arch Toxicol; 2016 Sep; 90(9):2049-2061. PubMed ID: 27325232
    [Abstract] [Full Text] [Related]

  • 23. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury.
    Laifenfeld D, Qiu L, Swiss R, Park J, Macoritto M, Will Y, Younis HS, Lawton M.
    Toxicol Sci; 2014 Jan; 137(1):234-48. PubMed ID: 24136188
    [Abstract] [Full Text] [Related]

  • 24. A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue.
    Ide I, Nagao E, Kajiyama S, Mizoguchi N.
    Toxicol Mech Methods; 2020 Mar; 30(3):189-196. PubMed ID: 31736396
    [Abstract] [Full Text] [Related]

  • 25. Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling.
    Driessen M, Kienhuis AS, Pennings JL, Pronk TE, van de Brandhof EJ, Roodbergen M, Spaink HP, van de Water B, van der Ven LT.
    Arch Toxicol; 2013 May; 87(5):807-23. PubMed ID: 23559145
    [Abstract] [Full Text] [Related]

  • 26. Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE.
    Chem Res Toxicol; 2012 Oct 15; 25(10):2067-82. PubMed ID: 22931300
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  • 27. Toxicogenomics strategies for predicting drug toxicity.
    Martin R, Rose D, Yu K, Barros S.
    Pharmacogenomics; 2006 Oct 15; 7(7):1003-16. PubMed ID: 17054411
    [Abstract] [Full Text] [Related]

  • 28. Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles.
    Zhang J, Doshi U, Suzuki A, Chang CW, Borlak J, Li AP, Tong W.
    Chem Biol Interact; 2016 Aug 05; 255():3-11. PubMed ID: 26581450
    [Abstract] [Full Text] [Related]

  • 29. Determination of the key innate genes related to individual variation in carbon tetrachloride-induced hepatotoxicity using a pre-biopsy procedure.
    Yun JW, Kim CW, Bae IH, Park YH, Chung JH, Lim KM, Kang KS.
    Toxicol Appl Pharmacol; 2009 Aug 15; 239(1):55-63. PubMed ID: 19481104
    [Abstract] [Full Text] [Related]

  • 30. Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models.
    Poon KL, Wang X, Lee SG, Ng AS, Goh WH, Zhao Z, Al-Haddawi M, Wang H, Mathavan S, Ingham PW, McGinnis C, Carney TJ.
    Toxicol Sci; 2017 Mar 01; 156(1):133-148. PubMed ID: 28069987
    [Abstract] [Full Text] [Related]

  • 31. Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project.
    Mandenius CF, Andersson TB, Alves PM, Batzl-Hartmann C, Björquist P, Carrondo MJ, Chesne C, Coecke S, Edsbagge J, Fredriksson JM, Gerlach JC, Heinzle E, Ingelman-Sundberg M, Johansson I, Küppers-Munther B, Müller-Vieira U, Noor F, Zeilinger K.
    Altern Lab Anim; 2011 May 01; 39(2):147-71. PubMed ID: 21639679
    [Abstract] [Full Text] [Related]

  • 32. A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity.
    He JH, Guo SY, Zhu F, Zhu JJ, Chen YX, Huang CJ, Gao JM, Dong QX, Xuan YX, Li CQ.
    J Pharmacol Toxicol Methods; 2013 May 01; 67(1):25-32. PubMed ID: 23128142
    [Abstract] [Full Text] [Related]

  • 33. Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.
    Driessen M, Kienhuis AS, Vitins AP, Pennings JL, Pronk TE, van den Brandhof EJ, Roodbergen M, van de Water B, van der Ven LT.
    Toxicol Lett; 2014 Oct 01; 230(1):48-56. PubMed ID: 25064622
    [Abstract] [Full Text] [Related]

  • 34. Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes.
    Elferink MG, Olinga P, van Leeuwen EM, Bauerschmidt S, Polman J, Schoonen WG, Heisterkamp SH, Groothuis GM.
    Toxicol Appl Pharmacol; 2011 May 15; 253(1):57-69. PubMed ID: 21420995
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  • 35. Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.
    Martínez-Sena T, Moro E, Moreno-Torres M, Quintás G, Hengstler J, Castell JV.
    Arch Toxicol; 2023 Jun 15; 97(6):1723-1738. PubMed ID: 37022445
    [Abstract] [Full Text] [Related]

  • 36. LTMap: a web server for assessing the potential liver toxicity by genome-wide transcriptional expression data.
    Xing L, Wu L, Liu Y, Ai N, Lu X, Fan X.
    J Appl Toxicol; 2014 Jul 15; 34(7):805-9. PubMed ID: 24022982
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  • 37. Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
    Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG.
    Arch Toxicol; 2019 Jun 15; 93(6):1609-1637. PubMed ID: 31250071
    [Abstract] [Full Text] [Related]

  • 38. In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
    Utkarsh D, Loretz C, Li AP.
    Chem Biol Interact; 2016 Aug 05; 255():12-22. PubMed ID: 26718876
    [Abstract] [Full Text] [Related]

  • 39. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.
    Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I.
    Toxicol Sci; 2009 Jul 05; 110(1):235-43. PubMed ID: 19420014
    [Abstract] [Full Text] [Related]

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