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432 related items for PubMed ID: 21920351

  • 1. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.
    Krausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P.
    Biochem Pharmacol; 2011 Dec 01; 82(11):1771-80. PubMed ID: 21920351
    [Abstract] [Full Text] [Related]

  • 2. Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.
    Ohbuchi M, Yoshinari K, Kaneko H, Matsumoto S, Inoue A, Kawamura A, Usui T, Yamazoe Y.
    Antimicrob Agents Chemother; 2013 Mar 01; 57(3):1332-8. PubMed ID: 23274663
    [Abstract] [Full Text] [Related]

  • 3. GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.
    Zhang S, Pan X, Jeong H.
    Drug Metab Dispos; 2015 May 01; 43(5):743-8. PubMed ID: 25725071
    [Abstract] [Full Text] [Related]

  • 4. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T, Chiang JY.
    Drug Metab Dispos; 2006 May 01; 34(5):756-64. PubMed ID: 16455805
    [Abstract] [Full Text] [Related]

  • 5. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.
    Drug Metab Dispos; 2007 Jul 01; 35(7):1032-41. PubMed ID: 17392393
    [Abstract] [Full Text] [Related]

  • 6. Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice.
    Yamasaki Y, Kobayashi K, Inaba A, Uehara D, Tojima H, Kakizaki S, Chiba K.
    Xenobiotica; 2018 Nov 01; 48(11):1098-1105. PubMed ID: 29095659
    [Abstract] [Full Text] [Related]

  • 7. Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.
    Sane RS, Buckley DJ, Buckley AR, Nallani SC, Desai PB.
    Drug Metab Dispos; 2008 May 01; 36(5):946-54. PubMed ID: 18299335
    [Abstract] [Full Text] [Related]

  • 8. Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.
    Hoffart E, Ghebreghiorghis L, Nussler AK, Thasler WE, Weiss TS, Schwab M, Burk O.
    Br J Pharmacol; 2012 Mar 01; 165(5):1595-608. PubMed ID: 21913896
    [Abstract] [Full Text] [Related]

  • 9. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
    Chang HY, Chen CJ, Ma WC, Cheng WK, Lin YN, Lee YR, Chen JJ, Lim YP.
    Phytomedicine; 2017 Dec 01; 36():37-49. PubMed ID: 29157826
    [Abstract] [Full Text] [Related]

  • 10. Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.
    Huang L, Huang M, Li YH, Li RM, Zeng Y, Kuang SY, Zhang L, Wang YT, Bi HC.
    J Ethnopharmacol; 2013 Jul 09; 148(2):596-602. PubMed ID: 23702042
    [Abstract] [Full Text] [Related]

  • 11. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.
    Pascussi JM, Drocourt L, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ.
    Eur J Biochem; 2001 Dec 09; 268(24):6346-58. PubMed ID: 11737189
    [Abstract] [Full Text] [Related]

  • 12. An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism.
    Li L, Sinz MW, Zimmermann K, Wang H.
    J Pharmacol Exp Ther; 2012 Mar 09; 340(3):688-97. PubMed ID: 22171088
    [Abstract] [Full Text] [Related]

  • 13. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
    Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG, Kim RB.
    Drug Metab Dispos; 2008 Mar 09; 36(3):500-7. PubMed ID: 18096673
    [Abstract] [Full Text] [Related]

  • 14. PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
    Yu C, Ye S, Sun H, Liu Y, Gao L, Shen C, Chen S, Zeng S.
    Chem Biol Interact; 2009 Jan 15; 177(1):58-64. PubMed ID: 18805405
    [Abstract] [Full Text] [Related]

  • 15. Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.
    Roth A, Looser R, Kaufmann M, Meyer UA.
    Pharmacogenet Genomics; 2008 Apr 15; 18(4):325-37. PubMed ID: 18334917
    [Abstract] [Full Text] [Related]

  • 16. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.
    Ding X, Lichti K, Staudinger JL.
    Toxicol Sci; 2006 Jun 15; 91(2):448-55. PubMed ID: 16547076
    [Abstract] [Full Text] [Related]

  • 17. Resveratrol suppresses the inducible expression of CYP3A4 through the pregnane X receptor.
    Deng R, Xu C, Chen X, Chen P, Wang Y, Zhou X, Jin J, Niu L, Ying M, Huang M, Bi H.
    J Pharmacol Sci; 2014 Jun 15; 126(2):146-54. PubMed ID: 25341566
    [Abstract] [Full Text] [Related]

  • 18. Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
    Park YJ, Lee EK, Lee YK, Park DJ, Jang HC, Moore DD.
    Toxicol Appl Pharmacol; 2012 Sep 01; 263(2):131-7. PubMed ID: 22503787
    [Abstract] [Full Text] [Related]

  • 19. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC, Das PC, Dekrey GK, Gardiner CS, Cao Y, Rose RL, Wallace AD.
    Toxicol Appl Pharmacol; 2010 Jun 15; 245(3):335-43. PubMed ID: 20361990
    [Abstract] [Full Text] [Related]

  • 20. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.
    Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P.
    Drug Metab Dispos; 2008 Feb 15; 36(2):339-48. PubMed ID: 17998298
    [Abstract] [Full Text] [Related]

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