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Journal Abstract Search

131 related items for PubMed ID: 21922418

  • 1. Prodrug design for brain delivery of small- and medium-sized neuropeptides.
    Prokai-Tatrai K, Prokai L.
    Methods Mol Biol; 2011; 789():313-36. PubMed ID: 21922418
    [Abstract] [Full Text] [Related]

  • 2. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.
    Peura L, Malmioja K, Laine K, Leppänen J, Gynther M, Isotalo A, Rautio J.
    Mol Pharm; 2011 Oct 03; 8(5):1857-66. PubMed ID: 21770378
    [Abstract] [Full Text] [Related]

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  • 4. Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents.
    Prokai-Tatrai K, Prokai L.
    Molecules; 2009 Feb 06; 14(2):633-54. PubMed ID: 19214153
    [Abstract] [Full Text] [Related]

  • 5. Prodrugs of peptides. 6. Bioreversible derivatives of thyrotropin-releasing hormone (TRH) with increased lipophilicity and resistance to cleavage by the TRH-specific serum enzyme.
    Bundgaard H, Møss J.
    Pharm Res; 1990 Sep 06; 7(9):885-92. PubMed ID: 2122435
    [Abstract] [Full Text] [Related]

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  • 7. Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Parkinson prodrugs.
    More SS, Vince R.
    J Med Chem; 2008 Aug 14; 51(15):4581-8. PubMed ID: 18651729
    [Abstract] [Full Text] [Related]

  • 8. Brain uptake of ketoprofen-lysine prodrug in rats.
    Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J.
    Int J Pharm; 2010 Oct 31; 399(1-2):121-8. PubMed ID: 20727958
    [Abstract] [Full Text] [Related]

  • 9. Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: an in vivo microdialysis study.
    Nguyen V, Zharikova AD, Prokai L.
    Neurosci Lett; 2007 Mar 19; 415(1):64-7. PubMed ID: 17234338
    [Abstract] [Full Text] [Related]

  • 10. Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease.
    Deguchi Y, Hayashi H, Fujii S, Naito T, Yokoyama Y, Yamada S, Kimura R.
    J Drug Target; 2000 Mar 19; 8(6):371-81. PubMed ID: 11328663
    [Abstract] [Full Text] [Related]

  • 11. [Synthesis of prodrugs of tacrine hydrochloride and evaluation of the stability and biodistribution in mice].
    Jiang Y, Zhang Y, Zhang ZR.
    Yao Xue Xue Bao; 2003 Dec 19; 38(12):962-5. PubMed ID: 15040096
    [Abstract] [Full Text] [Related]

  • 12. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM.
    Eur J Pharm Sci; 2019 Mar 01; 129():99-109. PubMed ID: 30625368
    [Abstract] [Full Text] [Related]

  • 13. Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium.
    Prokai L, Prokai-Tatrai K, Zharikova AD, Nguyen V, Perjesi P, Stevens SM.
    J Med Chem; 2004 Nov 18; 47(24):6025-33. PubMed ID: 15537357
    [Abstract] [Full Text] [Related]

  • 14. Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.
    Prokai-Tatrai K, Nguyen V, Zharikova AD, Braddy AC, Stevens SM, Prokai L.
    Bioorg Med Chem Lett; 2003 Mar 24; 13(6):1011-4. PubMed ID: 12643900
    [Abstract] [Full Text] [Related]

  • 15. Metabolism-based brain-targeting system for a thyrotropin-releasing hormone analogue.
    Prokai L, Prokai-Tatrai K, Ouyang X, Kim HS, Wu WM, Zharikova A, Bodor N.
    J Med Chem; 1999 Nov 04; 42(22):4563-71. PubMed ID: 10579819
    [Abstract] [Full Text] [Related]

  • 16. Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
    Sturk LM, Brock JL, Bagnell CR, Hall JE, Tidwell RR.
    Acta Trop; 2004 Jul 04; 91(2):131-43. PubMed ID: 15234662
    [Abstract] [Full Text] [Related]

  • 17. Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkages.
    Zhang Q, Liang Z, Chen LY, Sun X, Gong T, Zhang ZR.
    Arzneimittelforschung; 2012 Jun 04; 62(6):261-6. PubMed ID: 22407924
    [Abstract] [Full Text] [Related]

  • 18. [Studies on synthesis and properties of N-benzoyl-THA targeting for brain].
    Gong T, Zhang Z, Liu L.
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2004 Feb 04; 21(1):21-4. PubMed ID: 15022455
    [Abstract] [Full Text] [Related]

  • 19. Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.
    Greene DL, Hau VS, Abbruscato TJ, Bartosz H, Misicka A, Lipkowski AW, Hom S, Gillespie TJ, Hruby VJ, Davis TP.
    J Pharmacol Exp Ther; 1996 Jun 04; 277(3):1366-75. PubMed ID: 8667199
    [Abstract] [Full Text] [Related]

  • 20. Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.
    Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J.
    J Med Chem; 2009 May 28; 52(10):3348-53. PubMed ID: 19402664
    [Abstract] [Full Text] [Related]

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