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609 related items for PubMed ID: 21926342

  • 1. Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats.
    Nemoto S, Kobayashi T, Taguchi K, Matsumoto T, Kamata K.
    Am J Physiol Heart Circ Physiol; 2011 Dec; 301(6):H2383-94. PubMed ID: 21926342
    [Abstract] [Full Text] [Related]

  • 2. Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.
    Kobayashi T, Taguchi K, Nemoto S, Nogami T, Matsumoto T, Kamata K.
    Am J Physiol Heart Circ Physiol; 2009 Nov; 297(5):H1767-75. PubMed ID: 19717727
    [Abstract] [Full Text] [Related]

  • 3. Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.
    Taguchi K, Matsumoto T, Kamata K, Kobayashi T.
    Pharmacol Res; 2012 Jul; 66(1):41-50. PubMed ID: 22465219
    [Abstract] [Full Text] [Related]

  • 4. Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice.
    Taguchi K, Kobayashi T, Matsumoto T, Kamata K.
    Am J Physiol Heart Circ Physiol; 2011 Aug; 301(2):H571-83. PubMed ID: 21572010
    [Abstract] [Full Text] [Related]

  • 5. Akt/eNOS pathway activation in endothelium-dependent relaxation is preserved in aortas from female, but not from male, type 2 diabetic mice.
    Taguchi K, Matsumoto T, Kamata K, Kobayashi T.
    Pharmacol Res; 2012 Jan; 65(1):56-65. PubMed ID: 21933713
    [Abstract] [Full Text] [Related]

  • 6. Differential changes of aorta and carotid vasodilation in type 2 diabetic GK and OLETF rats: paradoxical roles of hyperglycemia and insulin.
    Zhong MF, Shen WL, Tabuchi M, Nakamura K, Chen YC, Qiao CZ, He J, Yang J, Zhang C, Kamenov Z, Higashino H, Chen H.
    Exp Diabetes Res; 2012 Jan; 2012():429020. PubMed ID: 21977022
    [Abstract] [Full Text] [Related]

  • 7. Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model.
    Taguchi K, Kobayashi T, Takenouchi Y, Matsumoto T, Kamata K.
    Pharmacol Res; 2011 Nov; 64(5):535-46. PubMed ID: 21571071
    [Abstract] [Full Text] [Related]

  • 8. Relationships among protein tyrosine phosphatase 1B, angiotensin II, and insulin-mediated aortic responses in type 2 diabetic Goto-Kakizaki rats.
    Nemoto S, Matsumoto T, Taguchi K, Kobayashi T.
    Atherosclerosis; 2014 Mar; 233(1):64-71. PubMed ID: 24529124
    [Abstract] [Full Text] [Related]

  • 9. CCN1 acutely increases nitric oxide production via integrin αvβ3-Akt-S6K-phosphorylation of endothelial nitric oxide synthase at the serine 1177 signaling axis.
    Hwang S, Lee HJ, Kim G, Won KJ, Park YS, Jo I.
    Free Radic Biol Med; 2015 Dec; 89():229-40. PubMed ID: 26393424
    [Abstract] [Full Text] [Related]

  • 10. Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats.
    Kobayashi T, Nemoto S, Ishida K, Taguchi K, Matsumoto T, Kamata K.
    Clin Sci (Lond); 2012 Sep; 123(6):375-86. PubMed ID: 22494112
    [Abstract] [Full Text] [Related]

  • 11. Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.
    Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G.
    Circ Res; 2004 May 14; 94(9):1211-8. PubMed ID: 15044323
    [Abstract] [Full Text] [Related]

  • 12. PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.
    Bulhak AA, Jung C, Ostenson CG, Lundberg JO, Sjöquist PO, Pernow J.
    Am J Physiol Heart Circ Physiol; 2009 Mar 14; 296(3):H719-27. PubMed ID: 19151258
    [Abstract] [Full Text] [Related]

  • 13. Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation.
    Lee JH, Palaia T, Ragolia L.
    Am J Physiol Cell Physiol; 2009 Feb 14; 296(2):C327-38. PubMed ID: 19052261
    [Abstract] [Full Text] [Related]

  • 14. ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
    Huisamen B, Pêrel SJ, Friedrich SO, Salie R, Strijdom H, Lochner A.
    Mol Cell Biochem; 2011 Mar 14; 349(1-2):21-31. PubMed ID: 21153603
    [Abstract] [Full Text] [Related]

  • 15. Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179.
    Watanabe T, Suzuki J, Yamawaki H, Sharma VK, Sheu SS, Berk BC.
    Circulation; 2005 Sep 20; 112(12):1798-805. PubMed ID: 16172287
    [Abstract] [Full Text] [Related]

  • 16. Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats.
    Stennett AK, Qiao X, Falone AE, Koledova VV, Khalil RA.
    Am J Physiol Heart Circ Physiol; 2009 Mar 20; 296(3):H745-55. PubMed ID: 19151255
    [Abstract] [Full Text] [Related]

  • 17. Beneficial effect of insulin in hyperhomocysteinemia and diabetes mellitus-induced vascular endothelium dysfunction: role of phosphoinositide dependent kinase and protein kinase B.
    Sharma S, Singh M, Sharma PL.
    Mol Cell Biochem; 2011 Feb 20; 348(1-2):21-32. PubMed ID: 21069435
    [Abstract] [Full Text] [Related]

  • 18. Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
    Takenouchi Y, Kobayashi T, Matsumoto T, Kamata K.
    J Pharmacol Sci; 2008 Apr 20; 106(4):600-8. PubMed ID: 18391484
    [Abstract] [Full Text] [Related]

  • 19. Mechanisms underlying altered extracellular nucleotide-induced contractions in mesenteric arteries from rats in later-stage type 2 diabetes: effect of ANG II type 1 receptor antagonism.
    Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T.
    Am J Physiol Heart Circ Physiol; 2011 Nov 20; 301(5):H1850-61. PubMed ID: 21856926
    [Abstract] [Full Text] [Related]

  • 20. Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.
    Nemoto S, Taguchi K, Matsumoto T, Kamata K, Kobayashi T.
    Am J Physiol Heart Circ Physiol; 2012 Oct 01; 303(7):H893-902. PubMed ID: 22886408
    [Abstract] [Full Text] [Related]

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