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Journal Abstract Search

372 related items for PubMed ID: 21939431

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  • 2. Predicting toxicities of reactive metabolite-positive drug candidates.
    Kalgutkar AS, Dalvie D.
    Annu Rev Pharmacol Toxicol; 2015; 55():35-54. PubMed ID: 25292426
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  • 3. Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective.
    Tang W, Lu AY.
    Drug Metab Rev; 2010 May; 42(2):225-49. PubMed ID: 19939207
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  • 4. Structural alerts, reactive metabolites, and protein covalent binding: how reliable are these attributes as predictors of drug toxicity?
    Kalgutkar AS, Didiuk MT.
    Chem Biodivers; 2009 Nov; 6(11):2115-37. PubMed ID: 19937848
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  • 5. Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.
    Thompson RA, Isin EM, Ogese MO, Mettetal JT, Williams DP.
    Chem Res Toxicol; 2016 Apr 18; 29(4):505-33. PubMed ID: 26735163
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  • 6. Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.
    Gómez-Lechón MJ, Tolosa L, Donato MT.
    J Appl Toxicol; 2016 Jun 18; 36(6):752-68. PubMed ID: 26691983
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  • 12. Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE.
    Chem Res Toxicol; 2012 Oct 15; 25(10):2067-82. PubMed ID: 22931300
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  • 15. Drug metabolite profiling and elucidation of drug-induced hepatotoxicity.
    Tang W.
    Expert Opin Drug Metab Toxicol; 2007 Jun 15; 3(3):407-20. PubMed ID: 17539747
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  • 18. Are chemically reactive metabolites responsible for adverse reactions to drugs?
    Williams DP, Kitteringham NR, Naisbitt DJ, Pirmohamed M, Smith DA, Park BK.
    Curr Drug Metab; 2002 Aug 15; 3(4):351-66. PubMed ID: 12093355
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  • 20. Selection of new chemical entities with decreased potential for adverse drug reactions.
    Park KB, Dalton-Brown E, Hirst C, Williams DP.
    Eur J Pharmacol; 2006 Nov 07; 549(1-3):1-8. PubMed ID: 16979156
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