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Journal Abstract Search

268 related items for PubMed ID: 21944287

  • 1. Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.
    Kassis P, Brzeszcz J, Bénéteau V, Lozach O, Meijer L, Le Guével R, Guillouzo C, Lewiński K, Bourg S, Colliandre L, Routier S, Mérour JY.
    Eur J Med Chem; 2011 Nov; 46(11):5416-34. PubMed ID: 21944287
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
    Jacquemard U, Dias N, Lansiaux A, Bailly C, Logé C, Robert JM, Lozach O, Meijer L, Mérour JY, Routier S.
    Bioorg Med Chem; 2008 May 01; 16(9):4932-53. PubMed ID: 18439832
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
    Kuo GH, Prouty C, Wang A, Emanuel S, Deangelis A, Zhang Y, Song F, Beall L, Connolly PJ, Karnachi P, Chen X, Gruninger RH, Sechler J, Fuentes-Pesquera A, Middleton SA, Jolliffe L, Murray WV.
    J Med Chem; 2005 Jul 28; 48(15):4892-909. PubMed ID: 16033269
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and antiproliferative evaluation of some new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine.
    Racané L, Kraljević Pavelić S, Ratkaj I, Stepanić V, Pavelić K, Tralić-Kulenović V, Karminski-Zamola G.
    Eur J Med Chem; 2012 Sep 28; 55():108-16. PubMed ID: 22841279
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.
    Kuo GH, Wang A, Emanuel S, Deangelis A, Zhang R, Connolly PJ, Murray WV, Gruninger RH, Sechler J, Fuentes-Pesquera A, Johnson D, Middleton SA, Jolliffe L, Chen X.
    J Med Chem; 2005 Mar 24; 48(6):1886-900. PubMed ID: 15771433
    [Abstract] [Full Text] [Related]

  • 6. Pyridinylquinoxalines and pyridinylpyridopyrazines as lead compounds for novel p38 alpha mitogen-activated protein kinase inhibitors.
    Koch P, Jahns H, Schattel V, Goettert M, Laufer S.
    J Med Chem; 2010 Feb 11; 53(3):1128-37. PubMed ID: 20078117
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  • 8. Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors.
    Ye Q, Cao J, Zhou X, Lv D, He Q, Yang B, Hu Y.
    Bioorg Med Chem; 2009 Jul 01; 17(13):4763-72. PubMed ID: 19447039
    [Abstract] [Full Text] [Related]

  • 9. Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents.
    Abadi AH, Abou-Seri SM, Abdel-Rahman DE, Klein C, Lozach O, Meijer L.
    Eur J Med Chem; 2006 Mar 01; 41(3):296-305. PubMed ID: 16494969
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and antitumor activity of 3-(2-phenyl-1,3-thiazol-4-yl)-1H-indoles and 3-(2-phenyl-1,3-thiazol-4-yl)-1H-7-azaindoles.
    Diana P, Carbone A, Barraja P, Montalbano A, Parrino B, Lopergolo A, Pennati M, Zaffaroni N, Cirrincione G.
    ChemMedChem; 2011 Jul 04; 6(7):1300-9. PubMed ID: 21523912
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  • 13. Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.
    Ermoli A, Bargiotti A, Brasca MG, Ciavolella A, Colombo N, Fachin G, Isacchi A, Menichincheri M, Molinari A, Montagnoli A, Pillan A, Rainoldi S, Sirtori FR, Sola F, Thieffine S, Tibolla M, Valsasina B, Volpi D, Santocanale C, Vanotti E.
    J Med Chem; 2009 Jul 23; 52(14):4380-90. PubMed ID: 19555113
    [Abstract] [Full Text] [Related]

  • 14. Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents.
    Lv PC, Li DD, Li QS, Lu X, Xiao ZP, Zhu HL.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5374-7. PubMed ID: 21802290
    [Abstract] [Full Text] [Related]

  • 15. Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors.
    Boschelli DH, Wang D, Prashad AS, Subrath J, Wu B, Niu C, Lee J, Yang X, Brennan A, Chaudhary D.
    Bioorg Med Chem Lett; 2009 Jul 01; 19(13):3623-6. PubMed ID: 19447612
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
    Li Q, Woods KW, Thomas S, Zhu GD, Packard G, Fisher J, Li T, Gong J, Dinges J, Song X, Abrams J, Luo Y, Johnson EF, Shi Y, Liu X, Klinghofer V, Des Jong R, Oltersdorf T, Stoll VS, Jakob CG, Rosenberg SH, Giranda VL.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):2000-7. PubMed ID: 16413780
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  • 17. Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.
    Bouchikhi F, Anizon F, Moreau P.
    Eur J Med Chem; 2009 Jun 01; 44(6):2705-10. PubMed ID: 19232788
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents.
    Lai MJ, Chang JY, Lee HY, Kuo CC, Lin MH, Hsieh HP, Chang CY, Wu JS, Wu SY, Shey KS, Liou JP.
    Eur J Med Chem; 2011 Sep 01; 46(9):3623-9. PubMed ID: 21641700
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  • 19. Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity.
    Dubinina GG, Platonov MO, Golovach SM, Borysko PO, Tolmachov AO, Volovenko YM.
    Eur J Med Chem; 2006 Jun 01; 41(6):727-37. PubMed ID: 16675067
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.
    Boschelli DH, Wu B, Barrios Sosa AC, Chen J, Asselin M, Cole DC, Lee J, Yang X, Chaudhary D.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2850-3. PubMed ID: 18434148
    [Abstract] [Full Text] [Related]

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