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Journal Abstract Search

681 related items for PubMed ID: 21954231

  • 1. IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.
    Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK.
    Hum Mol Genet; 2012 Jan 01; 21(1):101-14. PubMed ID: 21954231
    [Abstract] [Full Text] [Related]

  • 2. ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress.
    Lee H, Ahn HH, Lee W, Oh Y, Choi H, Shim SM, Shin J, Jung YK.
    Mol Neurobiol; 2016 Dec 01; 53(10):6620-6634. PubMed ID: 26637326
    [Abstract] [Full Text] [Related]

  • 3. Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.
    Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Petersén Å, Lindholm D, Korhonen L.
    Hum Mol Genet; 2014 Nov 15; 23(22):5928-39. PubMed ID: 24951540
    [Abstract] [Full Text] [Related]

  • 4. SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.
    Noh JY, Lee H, Song S, Kim NS, Im W, Kim M, Seo H, Chung CW, Chang JW, Ferrante RJ, Yoo YJ, Ryu H, Jung YK.
    J Biol Chem; 2009 Apr 24; 284(17):11318-25. PubMed ID: 19240033
    [Abstract] [Full Text] [Related]

  • 5. Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.
    Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, Truant R.
    Hum Mol Genet; 2007 Nov 01; 16(21):2600-15. PubMed ID: 17704510
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins.
    Reijonen S, Putkonen N, Nørremølle A, Lindholm D, Korhonen L.
    Exp Cell Res; 2008 Mar 10; 314(5):950-60. PubMed ID: 18255062
    [Abstract] [Full Text] [Related]

  • 7. GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins.
    Jiang Y, Lv H, Liao M, Xu X, Huang S, Tan H, Peng T, Zhang Y, Li H.
    Neurosci Lett; 2012 May 16; 516(2):182-7. PubMed ID: 22490889
    [Abstract] [Full Text] [Related]

  • 8. Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.
    Roze E, Betuing S, Deyts C, Marcon E, Brami-Cherrier K, Pagès C, Humbert S, Mérienne K, Caboche J.
    FASEB J; 2008 Apr 16; 22(4):1083-93. PubMed ID: 18029446
    [Abstract] [Full Text] [Related]

  • 9. Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.
    Zhou X, Li G, Kaplan A, Gaschler MM, Zhang X, Hou Z, Jiang M, Zott R, Cremers S, Stockwell BR, Duan W.
    Hum Mol Genet; 2018 May 01; 27(9):1545-1555. PubMed ID: 29462355
    [Abstract] [Full Text] [Related]

  • 10. Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells.
    Cheng X, Liu H, Jiang CC, Fang L, Chen C, Zhang XD, Jiang ZW.
    Int J Mol Med; 2014 Sep 01; 34(3):772-81. PubMed ID: 24970676
    [Abstract] [Full Text] [Related]

  • 11. The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.
    Rangone H, Poizat G, Troncoso J, Ross CA, MacDonald ME, Saudou F, Humbert S.
    Eur J Neurosci; 2004 Jan 01; 19(2):273-9. PubMed ID: 14725621
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  • 16. Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.
    Lajoie P, Snapp EL.
    J Cell Sci; 2011 Oct 01; 124(Pt 19):3332-43. PubMed ID: 21896647
    [Abstract] [Full Text] [Related]

  • 17. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
    Wong YC, Holzbaur EL.
    J Neurosci; 2014 Jan 22; 34(4):1293-305. PubMed ID: 24453320
    [Abstract] [Full Text] [Related]

  • 18. AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease.
    Zuleta A, Vidal RL, Armentano D, Parsons G, Hetz C.
    Biochem Biophys Res Commun; 2012 Apr 13; 420(3):558-63. PubMed ID: 22445760
    [Abstract] [Full Text] [Related]

  • 19. A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy.
    Atwal RS, Truant R.
    Autophagy; 2008 Jan 13; 4(1):91-3. PubMed ID: 17986868
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease.
    Cho KJ, Lee BI, Cheon SY, Kim HW, Kim HJ, Kim GW.
    Neuroscience; 2009 Nov 10; 163(4):1128-34. PubMed ID: 19646509
    [Abstract] [Full Text] [Related]

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