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183 related items for PubMed ID: 21956117

  • 1. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.
    Le Nours J, Bulloch EM, Zhang Z, Greenwood DR, Middleditch MJ, Dickson JM, Baker EN.
    J Biol Chem; 2011 Nov 25; 286(47):40706-16. PubMed ID: 21956117
    [Abstract] [Full Text] [Related]

  • 2. Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity.
    Vergis JM, Bulock KG, Fleming KG, Beardsley GP.
    J Biol Chem; 2001 Mar 16; 276(11):7727-33. PubMed ID: 11096114
    [Abstract] [Full Text] [Related]

  • 3. Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
    Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA.
    Nat Struct Biol; 2001 May 16; 8(5):402-6. PubMed ID: 11323713
    [Abstract] [Full Text] [Related]

  • 4. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) bifunctional enzyme from Candidatus Liberibacer asiaticus.
    Lonare S, Rode S, Verma P, Verma S, Kaur H, Alam MS, Wangmo P, Kumar P, Roy P, Sharma AK.
    Biochim Biophys Acta Proteins Proteom; 2024 Jul 01; 1872(4):141015. PubMed ID: 38615986
    [Abstract] [Full Text] [Related]

  • 5. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis.
    Verma P, Kar B, Varshney R, Roy P, Sharma AK.
    FEBS J; 2017 Dec 01; 284(24):4233-4261. PubMed ID: 29063699
    [Abstract] [Full Text] [Related]

  • 6. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.
    Wolan DW, Cheong CG, Greasley SE, Wilson IA.
    Biochemistry; 2004 Feb 10; 43(5):1171-83. PubMed ID: 14756553
    [Abstract] [Full Text] [Related]

  • 7. Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase.
    Vergis JM, Beardsley GP.
    Biochemistry; 2004 Feb 10; 43(5):1184-92. PubMed ID: 14756554
    [Abstract] [Full Text] [Related]

  • 8. Analysis of substrate binding in individual active sites of bifunctional human ATIC.
    Witkowska D, Cox HL, Hall TC, Wildsmith GC, Machin DC, Webb ME.
    Biochim Biophys Acta Proteins Proteom; 2018 Feb 10; 1866(2):254-263. PubMed ID: 29042184
    [Abstract] [Full Text] [Related]

  • 9. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.
    Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA.
    J Biol Chem; 2004 Apr 23; 279(17):18034-45. PubMed ID: 14966129
    [Abstract] [Full Text] [Related]

  • 10. A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase.
    Kang YN, Tran A, White RH, Ealick SE.
    Biochemistry; 2007 May 01; 46(17):5050-62. PubMed ID: 17407260
    [Abstract] [Full Text] [Related]

  • 11. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling.
    Bulock KG, Beardsley GP, Anderson KS.
    J Biol Chem; 2002 Jun 21; 277(25):22168-74. PubMed ID: 11948179
    [Abstract] [Full Text] [Related]

  • 12. De novo purine nucleotide biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase.
    Ni L, Guan K, Zalkin H, Dixon JE.
    Gene; 1991 Oct 15; 106(2):197-205. PubMed ID: 1937050
    [Abstract] [Full Text] [Related]

  • 13. Structural insights into the avian AICAR transformylase mechanism.
    Wolan DW, Greasley SE, Beardsley GP, Wilson IA.
    Biochemistry; 2002 Dec 31; 41(52):15505-13. PubMed ID: 12501179
    [Abstract] [Full Text] [Related]

  • 14. Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
    Li M, Jin C, Xu M, Zhou L, Li D, Yin Y.
    Cell Commun Signal; 2017 Dec 16; 15(1):52. PubMed ID: 29246230
    [Abstract] [Full Text] [Related]

  • 15. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
    Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA.
    Biochemistry; 2003 Sep 23; 42(37):10904-14. PubMed ID: 12974624
    [Abstract] [Full Text] [Related]

  • 16. Case report of a rare purine synthesis disorder due to 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICAR) deficiency.
    Joy P, Madhuri V, Palocaren T, Das S, Susan Cleave Abraham S, Korula S, Koshy B, Jose J, Chandran M, Danda S.
    Brain Dev; 2022 Oct 23; 44(9):645-649. PubMed ID: 35637059
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  • 20. AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization.
    Asby DJ, Cuda F, Beyaert M, Houghton FD, Cagampang FR, Tavassoli A.
    Chem Biol; 2015 Jul 23; 22(7):838-48. PubMed ID: 26144885
    [Abstract] [Full Text] [Related]

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