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Journal Abstract Search

381 related items for PubMed ID: 21958737

  • 1. Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
    Tan CM, Chen GS, Chen CS, Chang PT, Chern JW.
    Bioorg Med Chem; 2011 Nov 01; 19(21):6316-28. PubMed ID: 21958737
    [Abstract] [Full Text] [Related]

  • 2. Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
    Chen CS, Tan CM, Huang CH, Chang LC, Wang JP, Cheng FC, Chern JW.
    Bioorg Med Chem; 2010 Jan 15; 18(2):597-604. PubMed ID: 20056549
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
    Özadalı K, Özkanlı F, Jain S, Rao PP, Velázquez-Martínez CA.
    Bioorg Med Chem; 2012 May 01; 20(9):2912-22. PubMed ID: 22475926
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.
    Lai Y, Ma L, Huang W, Yu X, Zhang Y, Ji H, Tian J.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7349-53. PubMed ID: 21055929
    [Abstract] [Full Text] [Related]

  • 5. Aspirin analogues as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, nitric oxide release, molecular modeling, and biological evaluation as anti-inflammatory agents.
    Kaur J, Bhardwaj A, Huang Z, Knaus EE.
    ChemMedChem; 2012 Jan 02; 7(1):144-50. PubMed ID: 22095955
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7898-909. PubMed ID: 16904331
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
    Rao PN, Chen QH, Knaus EE.
    J Med Chem; 2006 Mar 09; 49(5):1668-83. PubMed ID: 16509583
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.
    Chowdhury MA, Huang Z, Abdellatif KR, Dong Y, Yu G, Velázquez CA, Knaus EE.
    Bioorg Med Chem Lett; 2010 Oct 01; 20(19):5776-80. PubMed ID: 20727750
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
    Reddy MV, Billa VK, Pallela VR, Mallireddigari MR, Boominathan R, Gabriel JL, Reddy EP.
    Bioorg Med Chem; 2008 Apr 01; 16(7):3907-16. PubMed ID: 18272371
    [Abstract] [Full Text] [Related]

  • 10. Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues.
    Zheng M, Zhang Z, Zhu W, Liu H, Luo X, Chen K, Jiang H.
    Bioorg Med Chem; 2006 May 15; 14(10):3428-37. PubMed ID: 16458008
    [Abstract] [Full Text] [Related]

  • 11. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.
    Li Y, Chen SH, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS.
    Bioorg Med Chem; 2011 Mar 15; 19(6):2074-83. PubMed ID: 21349729
    [Abstract] [Full Text] [Related]

  • 12. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
    Maghraby MT, Abou-Ghadir OMF, Abdel-Moty SG, Ali AY, Salem OIA.
    Bioorg Med Chem; 2020 Apr 01; 28(7):115403. PubMed ID: 32127262
    [Abstract] [Full Text] [Related]

  • 13. Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6138-41. PubMed ID: 18945614
    [Abstract] [Full Text] [Related]

  • 14. Identification and development of thiazole leads as COX-2/5-LOX inhibitors through in-vitro and in-vivo biological evaluation for anti-inflammatory activity.
    Jacob P J, Manju SL.
    Bioorg Chem; 2020 Jul 01; 100():103882. PubMed ID: 32361295
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.
    Pontiki E, Hadjipavlou-Litina D, Litinas K, Nicolotti O, Carotti A.
    Eur J Med Chem; 2011 Jan 01; 46(1):191-200. PubMed ID: 21106277
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives as direct 5-lipoxygenase inhibitors.
    Suh J, Yum EK, Cheon HG, Cho YS.
    Chem Biol Drug Des; 2012 Jul 01; 80(1):89-98. PubMed ID: 22404847
    [Abstract] [Full Text] [Related]

  • 17. The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase.
    Li L, Zeng H, Shan L, Yuan X, Li Y, Liu R, Zhang W.
    J Ethnopharmacol; 2012 Sep 28; 143(2):732-9. PubMed ID: 22884869
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
    Moreau A, Chen QH, Praveen Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7716-27. PubMed ID: 16931030
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Apr 01; 60(4):327-32. PubMed ID: 15848208
    [Abstract] [Full Text] [Related]

  • 20. Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
    Jiang B, Huang X, Yao H, Jiang J, Wu X, Jiang S, Wang Q, Lu T, Xu J.
    Org Biomol Chem; 2014 Apr 07; 12(13):2114-27. PubMed ID: 24562695
    [Abstract] [Full Text] [Related]

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