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285 related items for PubMed ID: 21985943

  • 1. K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.
    Minjgee M, Toulany M, Kehlbach R, Giehl K, Rodemann HP.
    Int J Radiat Oncol Biol Phys; 2011 Dec 01; 81(5):1506-14. PubMed ID: 21985943
    [Abstract] [Full Text] [Related]

  • 2. Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.
    Toulany M, Dittmann K, Krüger M, Baumann M, Rodemann HP.
    Radiother Oncol; 2005 Aug 01; 76(2):143-50. PubMed ID: 16024124
    [Abstract] [Full Text] [Related]

  • 3. Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity.
    Toulany M, Baumann M, Rodemann HP.
    Mol Cancer Res; 2007 Aug 01; 5(8):863-72. PubMed ID: 17699110
    [Abstract] [Full Text] [Related]

  • 4. Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance.
    Grana TM, Sartor CI, Cox AD.
    Cancer Res; 2003 Nov 15; 63(22):7807-14. PubMed ID: 14633707
    [Abstract] [Full Text] [Related]

  • 5. Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.
    Toulany M, Kasten-Pisula U, Brammer I, Wang S, Chen J, Dittmann K, Baumann M, Dikomey E, Rodemann HP.
    Clin Cancer Res; 2006 Jul 01; 12(13):4119-26. PubMed ID: 16818713
    [Abstract] [Full Text] [Related]

  • 6. PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.
    Toulany M, Dittmann K, Fehrenbacher B, Schaller M, Baumann M, Rodemann HP.
    DNA Repair (Amst); 2008 Oct 01; 7(10):1746-56. PubMed ID: 18678286
    [Abstract] [Full Text] [Related]

  • 7. Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro.
    Eke I, Sandfort V, Storch K, Baumann M, Röper B, Cordes N.
    Int J Radiat Biol; 2007 Oct 01; 83(11-12):793-802. PubMed ID: 18058367
    [Abstract] [Full Text] [Related]

  • 8. 2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities.
    Florczak U, Toulany M, Kehlbach R, Peter Rodemann H.
    Radiother Oncol; 2009 Sep 01; 92(3):334-8. PubMed ID: 19589609
    [Abstract] [Full Text] [Related]

  • 9. Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways.
    Grana TM, Rusyn EV, Zhou H, Sartor CI, Cox AD.
    Cancer Res; 2002 Jul 15; 62(14):4142-50. PubMed ID: 12124353
    [Abstract] [Full Text] [Related]

  • 10. Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells.
    Ligęza J, Ligęza J, Klein A.
    Acta Biochim Pol; 2011 Jul 15; 58(3):391-6. PubMed ID: 21887406
    [Abstract] [Full Text] [Related]

  • 11. Gefitinib radiosensitizes stem-like glioma cells: inhibition of epidermal growth factor receptor-Akt-DNA-PK signaling, accompanied by inhibition of DNA double-strand break repair.
    Kang KB, Zhu C, Wong YL, Gao Q, Ty A, Wong MC.
    Int J Radiat Oncol Biol Phys; 2012 May 01; 83(1):e43-52. PubMed ID: 22516386
    [Abstract] [Full Text] [Related]

  • 12. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
    Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, Minna JD.
    Cancer Res; 2006 Feb 15; 66(4):2116-28. PubMed ID: 16489012
    [Abstract] [Full Text] [Related]

  • 13. SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.
    Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR.
    Cancer Res; 2004 Sep 01; 64(17):6166-73. PubMed ID: 15342401
    [Abstract] [Full Text] [Related]

  • 14. Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways.
    Park CM, Park MJ, Kwak HJ, Lee HC, Kim MS, Lee SH, Park IC, Rhee CH, Hong SI.
    Cancer Res; 2006 Sep 01; 66(17):8511-9. PubMed ID: 16951163
    [Abstract] [Full Text] [Related]

  • 15. Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation.
    Ciardiello F, McGeady ML, Kim N, Basolo F, Hynes N, Langton BC, Yokozaki H, Saeki T, Elliott JW, Masui H.
    Cell Growth Differ; 1990 Sep 01; 1(9):407-20. PubMed ID: 1981145
    [Abstract] [Full Text] [Related]

  • 16. Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism.
    Dittmann KH, Mayer C, Ohneseit PA, Raju U, Andratschke NH, Milas L, Rodemann HP.
    Int J Radiat Oncol Biol Phys; 2008 Jan 01; 70(1):203-12. PubMed ID: 17996386
    [Abstract] [Full Text] [Related]

  • 17. Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation.
    Toulany M, Schickfluss TA, Eicheler W, Kehlbach R, Schittek B, Rodemann HP.
    Breast Cancer Res; 2011 Mar 10; 13(2):R28. PubMed ID: 21392397
    [Abstract] [Full Text] [Related]

  • 18. Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
    Luo F, Brooks DG, Ye H, Hamoudi R, Poulogiannis G, Patek CE, Winton DJ, Arends MJ.
    Oncogene; 2007 Jun 28; 26(30):4415-27. PubMed ID: 17297472
    [Abstract] [Full Text] [Related]

  • 19. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
    Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J, Lobrich M, Rodemann HP.
    Mol Cancer Ther; 2008 Jul 28; 7(7):1772-81. PubMed ID: 18644989
    [Abstract] [Full Text] [Related]

  • 20. Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS.
    Toulany M, Dittmann K, Baumann M, Rodemann HP.
    Radiother Oncol; 2005 Feb 28; 74(2):117-29. PubMed ID: 15734199
    [Abstract] [Full Text] [Related]

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