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Journal Abstract Search

83 related items for PubMed ID: 21986586

  • 1. Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
    Gahman TC, Herbert MR, Lang H, Thayer A, Symons KT, Nguyen PM, Massari ME, Dozier S, Zhang Y, Sablad M, Rao TS, Noble SA, Shiau AK, Hassig CA.
    Bioorg Med Chem Lett; 2011 Nov 15; 21(22):6888-94. PubMed ID: 21986586
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  • 2. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2009 May 14; 52(9):3047-62. PubMed ID: 19374401
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  • 4. Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
    Davey DD, Adler M, Arnaiz D, Eagen K, Erickson S, Guilford W, Kenrick M, Morrissey MM, Ohlmeyer M, Pan G, Paradkar VM, Parkinson J, Polokoff M, Saionz K, Santos C, Subramanyam B, Vergona R, Wei RG, Whitlow M, Ye B, Zhao ZS, Devlin JJ, Phillips G.
    J Med Chem; 2007 Mar 22; 50(6):1146-57. PubMed ID: 17315988
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  • 5. Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
    Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS.
    J Pharmacol Exp Ther; 2011 Feb 22; 336(2):468-78. PubMed ID: 21036913
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  • 8. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
    Tiso M, Strub A, Hesslinger C, Kenney CT, Boer R, Stuehr DJ.
    Mol Pharmacol; 2008 Apr 22; 73(4):1244-53. PubMed ID: 18178668
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  • 10. In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.
    Lehner MD, Marx D, Boer R, Strub A, Hesslinger C, Eltze M, Ulrich WR, Schwoebel F, Schermuly RT, Barsig J.
    J Pharmacol Exp Ther; 2006 Apr 22; 317(1):181-7. PubMed ID: 16368897
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  • 11. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation.
    Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY.
    Eur J Neurosci; 2007 May 22; 25(10):2964-72. PubMed ID: 17561811
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  • 12. Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1beta-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord.
    Sung CS, Wen ZH, Chang WK, Chan KH, Ho ST, Tsai SK, Chang YC, Wong CS.
    J Neurochem; 2005 Aug 22; 94(3):742-52. PubMed ID: 16033422
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  • 14. The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
    Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2468-71. PubMed ID: 21398123
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  • 15. 1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
    Wei RG, Adler M, Davey D, Ho E, Mohan R, Polokoff M, Tseng JL, Whitlow M, Xu W, Yuan S, Phillips G.
    Bioorg Med Chem Lett; 2007 May 01; 17(9):2499-504. PubMed ID: 17368901
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  • 16. Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors attenuates fever due to LPS in rats.
    Soszynski D, Chelminiak M.
    J Physiol Pharmacol; 2007 Sep 01; 58(3):551-61. PubMed ID: 17928650
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  • 20. Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
    Durón SG, Lindstrom A, Bonnefous C, Zhang H, Chen X, Symons KT, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1237-41. PubMed ID: 22182498
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