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Journal Abstract Search


1253 related items for PubMed ID: 22006998

  • 1. Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.
    Zhang M, Kleber S, Röhrich M, Timke C, Han N, Tuettenberg J, Martin-Villalba A, Debus J, Peschke P, Wirkner U, Lahn M, Huber PE.
    Cancer Res; 2011 Dec 01; 71(23):7155-67. PubMed ID: 22006998
    [Abstract] [Full Text] [Related]

  • 2. LY2109761 enhances cisplatin antitumor activity in ovarian cancer cells.
    Gao Y, Shan N, Zhao C, Wang Y, Xu F, Li J, Yu X, Gao L, Yi Z.
    Int J Clin Exp Pathol; 2015 Dec 01; 8(5):4923-32. PubMed ID: 26191185
    [Abstract] [Full Text] [Related]

  • 3. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
    Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH.
    Cancer Res; 2012 Aug 15; 72(16):4119-29. PubMed ID: 22693253
    [Abstract] [Full Text] [Related]

  • 4. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis.
    Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ.
    Mol Cancer Ther; 2008 Apr 15; 7(4):829-40. PubMed ID: 18413796
    [Abstract] [Full Text] [Related]

  • 5. Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.
    Zhang M, Herion TW, Timke C, Han N, Hauser K, Weber KJ, Peschke P, Wirkner U, Lahn M, Huber PE.
    Neoplasia; 2011 Jun 15; 13(6):537-49. PubMed ID: 21677877
    [Abstract] [Full Text] [Related]

  • 6. Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
    Timke C, Zieher H, Roth A, Hauser K, Lipson KE, Weber KJ, Debus J, Abdollahi A, Huber PE.
    Clin Cancer Res; 2008 Apr 01; 14(7):2210-9. PubMed ID: 18381963
    [Abstract] [Full Text] [Related]

  • 7. MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.
    Grzmil M, Morin P, Lino MM, Merlo A, Frank S, Wang Y, Moncayo G, Hemmings BA.
    Cancer Res; 2011 Mar 15; 71(6):2392-402. PubMed ID: 21406405
    [Abstract] [Full Text] [Related]

  • 8. Human glioblastoma and carcinoma xenograft tumors treated by combined radiation and imatinib (Gleevec).
    Oertel S, Krempien R, Lindel K, Zabel A, Milker-Zabel S, Bischof M, Lipson KE, Peschke P, Debus J, Abdollahi A, Huber PE.
    Strahlenther Onkol; 2006 Jul 15; 182(7):400-7. PubMed ID: 16826359
    [Abstract] [Full Text] [Related]

  • 9. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.
    Uhl M, Aulwurm S, Wischhusen J, Weiler M, Ma JY, Almirez R, Mangadu R, Liu YW, Platten M, Herrlinger U, Murphy A, Wong DH, Wick W, Higgins LS, Weller M.
    Cancer Res; 2004 Nov 01; 64(21):7954-61. PubMed ID: 15520202
    [Abstract] [Full Text] [Related]

  • 10. Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment.
    Medicherla S, Li L, Ma JY, Kapoun AM, Gaspar NJ, Liu YW, Mangadu R, O'Young G, Protter AA, Schreiner GF, Wong DH, Higgins LS.
    Anticancer Res; 2007 Nov 01; 27(6B):4149-57. PubMed ID: 18229422
    [Abstract] [Full Text] [Related]

  • 11. The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells.
    Kahn J, Hayman TJ, Jamal M, Rath BH, Kramp T, Camphausen K, Tofilon PJ.
    Neuro Oncol; 2014 Jan 01; 16(1):29-37. PubMed ID: 24311635
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.
    Gaspar NJ, Li L, Kapoun AM, Medicherla S, Reddy M, Li G, O'Young G, Quon D, Henson M, Damm DL, Muiru GT, Murphy A, Higgins LS, Chakravarty S, Wong DH.
    Mol Pharmacol; 2007 Jul 01; 72(1):152-61. PubMed ID: 17400764
    [Abstract] [Full Text] [Related]

  • 13. STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma.
    Geng L, Shinohara ET, Kim D, Tan J, Osusky K, Shyr Y, Hallahan DE.
    Int J Radiat Oncol Biol Phys; 2006 Jan 01; 64(1):263-71. PubMed ID: 16274936
    [Abstract] [Full Text] [Related]

  • 14. Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model.
    Tran TT, Uhl M, Ma JY, Janssen L, Sriram V, Aulwurm S, Kerr I, Lam A, Webb HK, Kapoun AM, Kizer DE, McEnroe G, Hart B, Axon J, Murphy A, Chakravarty S, Dugar S, Protter AA, Higgins LS, Wick W, Weller M, Wong DH.
    Neuro Oncol; 2007 Jul 01; 9(3):259-70. PubMed ID: 17522330
    [Abstract] [Full Text] [Related]

  • 15. Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis.
    Kang KB, Wang TT, Woon CT, Cheah ES, Moore XL, Zhu C, Wong MC.
    Int J Radiat Oncol Biol Phys; 2007 Mar 01; 67(3):888-96. PubMed ID: 17293239
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation.
    Mazzocca A, Fransvea E, Lavezzari G, Antonaci S, Giannelli G.
    Hepatology; 2009 Oct 01; 50(4):1140-51. PubMed ID: 19711426
    [Abstract] [Full Text] [Related]

  • 17. LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals.
    Flechsig P, Dadrich M, Bickelhaupt S, Jenne J, Hauser K, Timke C, Peschke P, Hahn EW, Gröne HJ, Yingling J, Lahn M, Wirkner U, Huber PE.
    Clin Cancer Res; 2012 Jul 01; 18(13):3616-27. PubMed ID: 22547771
    [Abstract] [Full Text] [Related]

  • 18. Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
    Alcock RA, Dey S, Chendil D, Inayat MS, Mohiuddin M, Hartman G, Chatfield LK, Gallicchio VS, Ahmed MM.
    Oncogene; 2002 Nov 07; 21(51):7883-90. PubMed ID: 12420225
    [Abstract] [Full Text] [Related]

  • 19. Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth.
    Wan X, Li ZG, Yingling JM, Yang J, Starbuck MW, Ravoori MK, Kundra V, Vazquez E, Navone NM.
    Bone; 2012 Mar 07; 50(3):695-703. PubMed ID: 22173053
    [Abstract] [Full Text] [Related]

  • 20. TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.
    Bouquet F, Pal A, Pilones KA, Demaria S, Hann B, Akhurst RJ, Babb JS, Lonning SM, DeWyngaert JK, Formenti SC, Barcellos-Hoff MH.
    Clin Cancer Res; 2011 Nov 01; 17(21):6754-65. PubMed ID: 22028490
    [Abstract] [Full Text] [Related]


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