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Journal Abstract Search

1057 related items for PubMed ID: 22023459

  • 1. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I, Juárez-Jiménez J, de Los Ríos C, Chioua M, Pouplana R, Luque FJ, Unzeta M, Marco-Contelles J, Samadi A.
    J Med Chem; 2011 Dec 22; 54(24):8251-70. PubMed ID: 22023459
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
    Bautista-Aguilera OM, Esteban G, Bolea I, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Samadi A, Soriano E, Unzeta M, Marco-Contelles J.
    Eur J Med Chem; 2014 Mar 21; 75():82-95. PubMed ID: 24530494
    [Abstract] [Full Text] [Related]

  • 3. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
    Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J.
    Eur J Med Chem; 2012 Jun 21; 52():251-62. PubMed ID: 22503231
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.
    Li F, Wang ZM, Wu JJ, Wang J, Xie SS, Lan JS, Xu W, Kong LY, Wang XB.
    J Enzyme Inhib Med Chem; 2016 Jun 21; 31(sup3):41-53. PubMed ID: 27384289
    [Abstract] [Full Text] [Related]

  • 5. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
    Bautista-Aguilera OM, Esteban G, Chioua M, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Soriano E, Samadi A, Unzeta M, Marco-Contelles J.
    Drug Des Devel Ther; 2014 Jun 21; 8():1893-910. PubMed ID: 25378907
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Sang Z, Pan W, Wang K, Ma Q, Yu L, Liu W.
    Bioorg Med Chem; 2017 Jun 15; 25(12):3006-3017. PubMed ID: 28487125
    [Abstract] [Full Text] [Related]

  • 7. Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.
    Samadi A, Estrada M, Pérez C, Rodríguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Marco-Contelles J.
    Eur J Med Chem; 2012 Nov 15; 57():296-301. PubMed ID: 23078965
    [Abstract] [Full Text] [Related]

  • 8. Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.
    Samadi A, Chioua M, Bolea I, de Los Ríos C, Iriepa I, Moraleda I, Bastida A, Esteban G, Unzeta M, Gálvez E, Marco-Contelles J.
    Eur J Med Chem; 2011 Sep 15; 46(9):4665-8. PubMed ID: 21669479
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
    Joubert J, Foka GB, Repsold BP, Oliver DW, Kapp E, Malan SF.
    Eur J Med Chem; 2017 Jan 05; 125():853-864. PubMed ID: 27744252
    [Abstract] [Full Text] [Related]

  • 10. Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
    Wang L, Esteban G, Ojima M, Bautista-Aguilera OM, Inokuchi T, Moraleda I, Iriepa I, Samadi A, Youdim MB, Romero A, Soriano E, Herrero R, Fernández Fernández AP, Ricardo-Martínez-Murillo, Marco-Contelles J, Unzeta M.
    Eur J Med Chem; 2014 Jun 10; 80():543-61. PubMed ID: 24813882
    [Abstract] [Full Text] [Related]

  • 11. N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
    Bautista-Aguilera OM, Samadi A, Chioua M, Nikolic K, Filipic S, Agbaba D, Soriano E, de Andrés L, Rodríguez-Franco MI, Alcaro S, Ramsay RR, Ortuso F, Yañez M, Marco-Contelles J.
    J Med Chem; 2014 Dec 26; 57(24):10455-63. PubMed ID: 25418133
    [Abstract] [Full Text] [Related]

  • 12. Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
    Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.
    Bioorg Med Chem; 2007 Oct 15; 15(20):6596-607. PubMed ID: 17681794
    [Abstract] [Full Text] [Related]

  • 13. Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
    Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallàs M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ.
    J Med Chem; 2008 Jun 26; 51(12):3588-98. PubMed ID: 18517184
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
    Wang J, Wang ZM, Li XM, Li F, Wu JJ, Kong LY, Wang XB.
    Bioorg Med Chem; 2016 Sep 15; 24(18):4324-4338. PubMed ID: 27460699
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
    Shao D, Zou C, Luo C, Tang X, Li Y.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4639-42. PubMed ID: 15324879
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.
    Luo Z, Sheng J, Sun Y, Lu C, Yan J, Liu A, Luo HB, Huang L, Li X.
    J Med Chem; 2013 Nov 27; 56(22):9089-99. PubMed ID: 24160297
    [Abstract] [Full Text] [Related]

  • 17. Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
    Tang H, Zhao LZ, Zhao HT, Huang SL, Zhong SM, Qin JK, Chen ZF, Huang ZS, Liang H.
    Eur J Med Chem; 2011 Oct 27; 46(10):4970-9. PubMed ID: 21871694
    [Abstract] [Full Text] [Related]

  • 18. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.
    Košak U, Strašek N, Knez D, Jukič M, Žakelj S, Zahirović A, Pišlar A, Brazzolotto X, Nachon F, Kos J, Gobec S.
    Eur J Med Chem; 2020 Jul 01; 197():112282. PubMed ID: 32380361
    [Abstract] [Full Text] [Related]

  • 19. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
    Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K, Andrs M, Musilek K, Opletalova V, Sepsova V, Ripova D, Kuca K.
    Eur J Med Chem; 2014 Jul 23; 82():426-38. PubMed ID: 24929293
    [Abstract] [Full Text] [Related]

  • 20. Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.
    Huang L, Lu C, Sun Y, Mao F, Luo Z, Su T, Jiang H, Shan W, Li X.
    J Med Chem; 2012 Oct 11; 55(19):8483-92. PubMed ID: 22978824
    [Abstract] [Full Text] [Related]

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