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Journal Abstract Search

215 related items for PubMed ID: 22053912

  • 1. Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
    Abedin Z, Sen S, Field J.
    Chem Res Toxicol; 2012 Jan 13; 25(1):113-21. PubMed ID: 22053912
    [Abstract] [Full Text] [Related]

  • 2. Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
    Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.
    Chem Res Toxicol; 2011 Dec 19; 24(12):2153-66. PubMed ID: 21910479
    [Abstract] [Full Text] [Related]

  • 3. Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.
    Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM.
    Proc Natl Acad Sci U S A; 2008 May 13; 105(19):6846-51. PubMed ID: 18474869
    [Abstract] [Full Text] [Related]

  • 4. Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.
    Yu D, Berlin JA, Penning TM, Field J.
    Chem Res Toxicol; 2002 Jun 13; 15(6):832-42. PubMed ID: 12067251
    [Abstract] [Full Text] [Related]

  • 5. Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.
    Palackal NT, Lee SH, Harvey RG, Blair IA, Penning TM.
    J Biol Chem; 2002 Jul 05; 277(27):24799-808. PubMed ID: 11978787
    [Abstract] [Full Text] [Related]

  • 6. The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation.
    Palackal NT, Burczynski ME, Harvey RG, Penning TM.
    Biochemistry; 2001 Sep 11; 40(36):10901-10. PubMed ID: 11535067
    [Abstract] [Full Text] [Related]

  • 7. Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection.
    Shen YM, Troxel AB, Vedantam S, Penning TM, Field J.
    Chem Res Toxicol; 2006 Nov 11; 19(11):1441-50. PubMed ID: 17112231
    [Abstract] [Full Text] [Related]

  • 8. Comparisons of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol activation by human cytochrome P450 and aldo-keto reductase enzymes: effect of redox state and expression levels.
    Quinn AM, Penning TM.
    Chem Res Toxicol; 2008 May 11; 21(5):1086-94. PubMed ID: 18402469
    [Abstract] [Full Text] [Related]

  • 9. Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
    Penning TM.
    Chem Res Toxicol; 2014 Nov 17; 27(11):1901-17. PubMed ID: 25279998
    [Abstract] [Full Text] [Related]

  • 10. The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance.
    Park JH, Gelhaus S, Vedantam S, Oliva AL, Batra A, Blair IA, Troxel AB, Field J, Penning TM.
    Chem Res Toxicol; 2008 May 17; 21(5):1039-49. PubMed ID: 18489080
    [Abstract] [Full Text] [Related]

  • 11. Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts.
    Jiang H, Shen YM, Quinn AM, Penning TM.
    Chem Res Toxicol; 2005 Feb 17; 18(2):365-74. PubMed ID: 15720144
    [Abstract] [Full Text] [Related]

  • 12. Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism.
    Penning TM.
    Chem Biol Interact; 1993 Oct 17; 89(1):1-34. PubMed ID: 8221964
    [Abstract] [Full Text] [Related]

  • 13. Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction.
    Jiang H, Vudathala DK, Blair IA, Penning TM.
    Chem Res Toxicol; 2006 Jan 17; 19(1):68-78. PubMed ID: 16411658
    [Abstract] [Full Text] [Related]

  • 14. Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry.
    Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, Penning TM.
    Chem Res Toxicol; 2007 Sep 17; 20(9):1331-41. PubMed ID: 17702526
    [Abstract] [Full Text] [Related]

  • 15. Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells.
    Ruan Q, Gelhaus SL, Penning TM, Harvey RG, Blair IA.
    Chem Res Toxicol; 2007 Mar 17; 20(3):424-31. PubMed ID: 17295519
    [Abstract] [Full Text] [Related]

  • 16. Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species.
    Park JH, Troxel AB, Harvey RG, Penning TM.
    Chem Res Toxicol; 2006 May 17; 19(5):719-28. PubMed ID: 16696575
    [Abstract] [Full Text] [Related]

  • 17. Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation.
    Mounho BJ, Burchiel SW.
    Toxicol Appl Pharmacol; 1998 Mar 17; 149(1):80-9. PubMed ID: 9512730
    [Abstract] [Full Text] [Related]

  • 18. Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
    Quinn AM, Harvey RG, Penning TM.
    Chem Res Toxicol; 2008 Nov 17; 21(11):2207-15. PubMed ID: 18788756
    [Abstract] [Full Text] [Related]

  • 19. Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
    Burczynski ME, Penning TM.
    Cancer Res; 2000 Feb 15; 60(4):908-15. PubMed ID: 10706104
    [Abstract] [Full Text] [Related]

  • 20. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
    Burczynski ME, Lin HK, Penning TM.
    Cancer Res; 1999 Feb 01; 59(3):607-14. PubMed ID: 9973208
    [Abstract] [Full Text] [Related]

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