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Journal Abstract Search

160 related items for PubMed ID: 22079758

  • 1. Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocket.
    Dong M, Pinon DI, Miller LJ.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):638-41. PubMed ID: 22079758
    [Abstract] [Full Text] [Related]

  • 2. Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity.
    Chen Q, Pinon DI, Miller LJ, Dong M.
    J Biol Chem; 2010 Aug 06; 285(32):24508-18. PubMed ID: 20529866
    [Abstract] [Full Text] [Related]

  • 3. Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes.
    Chen Q, Pinon DI, Miller LJ, Dong M.
    J Biol Chem; 2009 Dec 04; 284(49):34135-44. PubMed ID: 19815559
    [Abstract] [Full Text] [Related]

  • 4. Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors.
    Dong M, Gao F, Pinon DI, Miller LJ.
    Mol Endocrinol; 2008 Jun 04; 22(6):1489-99. PubMed ID: 18372345
    [Abstract] [Full Text] [Related]

  • 5. Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.
    Miller LJ, Chen Q, Lam PC, Pinon DI, Sexton PM, Abagyan R, Dong M.
    J Biol Chem; 2011 May 06; 286(18):15895-907. PubMed ID: 21454562
    [Abstract] [Full Text] [Related]

  • 6. Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Incorporation of seven sets of such constraints into a three-dimensional model of the agonist-bound secretin receptor.
    Dong M, Li Z, Zang M, Pinon DI, Lybrand TP, Miller LJ.
    J Biol Chem; 2003 Nov 28; 278(48):48300-12. PubMed ID: 14500709
    [Abstract] [Full Text] [Related]

  • 7. Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.
    Coopman K, Wallis R, Robb G, Brown AJ, Wilkinson GF, Timms D, Willars GB.
    Mol Endocrinol; 2011 Oct 28; 25(10):1804-18. PubMed ID: 21868452
    [Abstract] [Full Text] [Related]

  • 8. Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor.
    Dong M, Li Z, Pinon DI, Lybrand TP, Miller LJ.
    J Biol Chem; 2004 Jan 23; 279(4):2894-903. PubMed ID: 14593094
    [Abstract] [Full Text] [Related]

  • 9. Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.
    Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.
    J Biol Chem; 2010 Mar 26; 285(13):9919-9931. PubMed ID: 20100828
    [Abstract] [Full Text] [Related]

  • 10. Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.
    Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ.
    J Biol Chem; 2011 Jul 08; 286(27):23888-99. PubMed ID: 21566140
    [Abstract] [Full Text] [Related]

  • 11. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
    Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.
    J Biol Chem; 2012 Feb 03; 287(6):3642-58. PubMed ID: 22147710
    [Abstract] [Full Text] [Related]

  • 12. High potency antagonists of the pancreatic glucagon-like peptide-1 receptor.
    Montrose-Rafizadeh C, Yang H, Rodgers BD, Beday A, Pritchette LA, Eng J.
    J Biol Chem; 1997 Aug 22; 272(34):21201-6. PubMed ID: 9261127
    [Abstract] [Full Text] [Related]

  • 13. A peptide agonist acts by occupation of a monomeric G protein-coupled receptor: dual sites of covalent attachment to domains near TM1 and TM7 of the same molecule make biologically significant domain-swapped dimerization unlikely.
    Hadac EM, Ji Z, Pinon DI, Henne RM, Lybrand TP, Miller LJ.
    J Med Chem; 1999 Jun 17; 42(12):2105-11. PubMed ID: 10377216
    [Abstract] [Full Text] [Related]

  • 14. Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors.
    Dong M, Pinon DI, Asmann YW, Miller LJ.
    Mol Pharmacol; 2006 Jul 17; 70(1):206-13. PubMed ID: 16531505
    [Abstract] [Full Text] [Related]

  • 15. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.
    Estall JL, Koehler JA, Yusta B, Drucker DJ.
    J Biol Chem; 2005 Jun 10; 280(23):22124-34. PubMed ID: 15817468
    [Abstract] [Full Text] [Related]

  • 16. Structurally related peptide agonist, partial agonist, and antagonist occupy a similar binding pocket within the cholecystokinin receptor. Rapid analysis using fluorescent photoaffinity labeling probes and capillary electrophoresis.
    Dong M, Ding XQ, Pinon DI, Hadac EM, Oda RP, Landers JP, Miller LJ.
    J Biol Chem; 1999 Feb 19; 274(8):4778-85. PubMed ID: 9988716
    [Abstract] [Full Text] [Related]

  • 17. Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists.
    Nakashima R, Yano T, Ogawa J, Tanaka N, Toda N, Yoshida M, Takano R, Inoue M, Honda T, Kume S, Matsumoto K.
    Eur J Pharmacol; 2014 Aug 15; 737():194-201. PubMed ID: 24858371
    [Abstract] [Full Text] [Related]

  • 18. Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.
    Dong M, Lam PC, Orry A, Sexton PM, Christopoulos A, Abagyan R, Miller LJ.
    J Biol Chem; 2016 Mar 04; 291(10):5172-84. PubMed ID: 26740626
    [Abstract] [Full Text] [Related]

  • 19. Differential docking of high-affinity peptide ligands to type A and B cholecystokinin receptors demonstrated by photoaffinity labeling.
    Dong M, Liu G, Pinon DI, Miller LJ.
    Biochemistry; 2005 May 03; 44(17):6693-700. PubMed ID: 15850403
    [Abstract] [Full Text] [Related]

  • 20. Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor.
    Zang M, Dong M, Pinon DI, Ding XQ, Hadac EM, Li Z, Lybrand TP, Miller LJ.
    Mol Pharmacol; 2003 May 03; 63(5):993-1001. PubMed ID: 12695527
    [Abstract] [Full Text] [Related]

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