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Journal Abstract Search

160 related items for PubMed ID: 22079758

  • 21. Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.
    Dong M, Lam PC, Pinon DI, Sexton PM, Abagyan R, Miller LJ.
    Mol Pharmacol; 2008 Aug; 74(2):413-22. PubMed ID: 18467541
    [Abstract] [Full Text] [Related]

  • 22. Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor.
    Dong M, Pinon DI, Cox RF, Miller LJ.
    J Biol Chem; 2004 Jan 09; 279(2):1167-75. PubMed ID: 14583624
    [Abstract] [Full Text] [Related]

  • 23. Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).
    Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW.
    J Biol Chem; 2016 Jun 17; 291(25):12991-3004. PubMed ID: 27059958
    [Abstract] [Full Text] [Related]

  • 24. Rational development of a high-affinity secretin receptor antagonist.
    Dong M, Harikumar KG, Raval SR, Milburn JE, Clark C, Alcala-Torano R, Mobarec JC, Reynolds CA, Ghirlanda G, Christopoulos A, Wootten D, Sexton PM, Miller LJ.
    Biochem Pharmacol; 2020 Jul 17; 177():113929. PubMed ID: 32217097
    [Abstract] [Full Text] [Related]

  • 25. Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.
    Harikumar KG, Wootten D, Pinon DI, Koole C, Ball AM, Furness SG, Graham B, Dong M, Christopoulos A, Miller LJ, Sexton PM.
    Proc Natl Acad Sci U S A; 2012 Nov 06; 109(45):18607-12. PubMed ID: 23091034
    [Abstract] [Full Text] [Related]

  • 26. Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor.
    Kirkpatrick A, Heo J, Abrol R, Goddard WA.
    Proc Natl Acad Sci U S A; 2012 Dec 04; 109(49):19988-93. PubMed ID: 23169631
    [Abstract] [Full Text] [Related]

  • 27. Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist.
    Pan CQ, Buxton JM, Yung SL, Tom I, Yang L, Chen H, MacDougall M, Bell A, Claus TH, Clairmont KB, Whelan JP.
    J Biol Chem; 2006 May 05; 281(18):12506-15. PubMed ID: 16505481
    [Abstract] [Full Text] [Related]

  • 28. Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.
    Lei S, Clydesdale L, Dai A, Cai X, Feng Y, Yang D, Liang YL, Koole C, Zhao P, Coudrat T, Christopoulos A, Wang MW, Wootten D, Sexton PM.
    J Biol Chem; 2018 Jun 15; 293(24):9370-9387. PubMed ID: 29717000
    [Abstract] [Full Text] [Related]

  • 29. A β-peptide agonist of the GLP-1 receptor, a class B GPCR.
    Denton EV, Craig CJ, Pongratz RL, Appelbaum JS, Doerner AE, Narayanan A, Shulman GI, Cline GW, Schepartz A.
    Org Lett; 2013 Oct 18; 15(20):5318-21. PubMed ID: 24087900
    [Abstract] [Full Text] [Related]

  • 30. Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor.
    Dong M, Wang Y, Hadac EM, Pinon DI, Holicky E, Miller LJ.
    J Biol Chem; 1999 Jul 02; 274(27):19161-7. PubMed ID: 10383421
    [Abstract] [Full Text] [Related]

  • 31. Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor.
    Pham V, Wade JD, Purdue BW, Sexton PM.
    J Biol Chem; 2004 Feb 20; 279(8):6720-9. PubMed ID: 14623894
    [Abstract] [Full Text] [Related]

  • 32. The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.
    Graziano MP, Hey PJ, Strader CD.
    Recept Channels; 1996 Feb 20; 4(1):9-17. PubMed ID: 8723643
    [Abstract] [Full Text] [Related]

  • 33. Mutational analysis of the glucagon receptor: similarities with the vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide (PACAP)/secretin receptors for recognition of the ligand's third residue.
    Perret J, Van Craenenbroeck M, Langer I, Vertongen P, Gregoire F, Robberecht P, Waelbroeck M.
    Biochem J; 2002 Mar 01; 362(Pt 2):389-94. PubMed ID: 11853547
    [Abstract] [Full Text] [Related]

  • 34. Identification of two pairs of spatially approximated residues within the carboxyl terminus of secretin and its receptor.
    Dong M, Asmann YW, Zang M, Pinon DI, Miller LJ.
    J Biol Chem; 2000 Aug 25; 275(34):26032-9. PubMed ID: 10859300
    [Abstract] [Full Text] [Related]

  • 35. Juxtamembranous region of the amino terminus of the family B G protein-coupled calcitonin receptor plays a critical role in small-molecule agonist action.
    Dong M, Cox RF, Miller LJ.
    J Biol Chem; 2009 Aug 14; 284(33):21839-21847. PubMed ID: 19447889
    [Abstract] [Full Text] [Related]

  • 36. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.
    Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S.
    J Biol Chem; 2010 Jan 01; 285(1):723-30. PubMed ID: 19861722
    [Abstract] [Full Text] [Related]

  • 37. Exploration of structure-activity relationships at the two C-terminal residues of potent 11mer Glucagon-Like Peptide-1 receptor agonist peptides via parallel synthesis.
    Haque TS, Martinez RL, Lee VG, Riexinger DG, Lei M, Feng M, Koplowitz B, Mapelli C, Cooper CB, Zhang G, Huang C, Ewing WR, Krupinski J.
    Peptides; 2010 Jul 01; 31(7):1353-60. PubMed ID: 20420872
    [Abstract] [Full Text] [Related]

  • 38. Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
    Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.
    J Pharmacol Exp Ther; 2015 Apr 01; 353(1):52-63. PubMed ID: 25630467
    [Abstract] [Full Text] [Related]

  • 39. Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors.
    Yin Y, de Waal PW, He Y, Zhao LH, Yang D, Cai X, Jiang Y, Melcher K, Wang MW, Xu HE.
    J Biol Chem; 2017 Jun 16; 292(24):9865-9881. PubMed ID: 28356352
    [Abstract] [Full Text] [Related]

  • 40. Identification of potent 11mer glucagon-like peptide-1 receptor agonist peptides with novel C-terminal amino acids: Homohomophenylalanine analogs.
    Haque TS, Lee VG, Riexinger D, Lei M, Malmstrom S, Xin L, Han S, Mapelli C, Cooper CB, Zhang G, Ewing WR, Krupinski J.
    Peptides; 2010 May 16; 31(5):950-5. PubMed ID: 20138099
    [Abstract] [Full Text] [Related]

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