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Journal Abstract Search

192 related items for PubMed ID: 22134089

  • 1. Transmembrane α-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor.
    Rye Underwood C, Møller Knudsen S, Schjellerup Wulff B, Bräuner-Osborne H, Lau J, Knudsen LB, Peters GH, Reedtz-Runge S.
    Pharmacology; 2011; 88(5-6):340-8. PubMed ID: 22134089
    [Abstract] [Full Text] [Related]

  • 2. Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.
    Coopman K, Wallis R, Robb G, Brown AJ, Wilkinson GF, Timms D, Willars GB.
    Mol Endocrinol; 2011 Oct; 25(10):1804-18. PubMed ID: 21868452
    [Abstract] [Full Text] [Related]

  • 3. Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.
    Chepurny OG, Matsoukas MT, Liapakis G, Leech CA, Milliken BT, Doyle RP, Holz GG.
    J Biol Chem; 2019 Mar 08; 294(10):3514-3531. PubMed ID: 30622136
    [Abstract] [Full Text] [Related]

  • 4. Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
    Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.
    J Pharmacol Exp Ther; 2015 Apr 08; 353(1):52-63. PubMed ID: 25630467
    [Abstract] [Full Text] [Related]

  • 5. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
    Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.
    J Biol Chem; 2012 Feb 03; 287(6):3642-58. PubMed ID: 22147710
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  • 6. Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the Gαq pathway.
    Thompson A, Kanamarlapudi V.
    Biochem Pharmacol; 2015 Jan 01; 93(1):72-84. PubMed ID: 25449603
    [Abstract] [Full Text] [Related]

  • 7. Characterization of glucagon-like peptide-1 receptor-binding determinants.
    Xiao Q, Jeng W, Wheeler MB.
    J Mol Endocrinol; 2000 Dec 01; 25(3):321-35. PubMed ID: 11116211
    [Abstract] [Full Text] [Related]

  • 8. Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity.
    Runge S, Wulff BS, Madsen K, Bräuner-Osborne H, Knudsen LB.
    Br J Pharmacol; 2003 Mar 01; 138(5):787-94. PubMed ID: 12642379
    [Abstract] [Full Text] [Related]

  • 9. A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain.
    Tibaduiza EC, Chen C, Beinborn M.
    J Biol Chem; 2001 Oct 12; 276(41):37787-93. PubMed ID: 11498540
    [Abstract] [Full Text] [Related]

  • 10. The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.
    Graziano MP, Hey PJ, Strader CD.
    Recept Channels; 1996 Oct 12; 4(1):9-17. PubMed ID: 8723643
    [Abstract] [Full Text] [Related]

  • 11. Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling.
    Heller RS, Kieffer TJ, Habener JF.
    Biochem Biophys Res Commun; 1996 Jun 25; 223(3):624-32. PubMed ID: 8687446
    [Abstract] [Full Text] [Related]

  • 12. Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.
    Harikumar KG, Wootten D, Pinon DI, Koole C, Ball AM, Furness SG, Graham B, Dong M, Christopoulos A, Miller LJ, Sexton PM.
    Proc Natl Acad Sci U S A; 2012 Nov 06; 109(45):18607-12. PubMed ID: 23091034
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  • 15. Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently.
    Cheong YH, Kim MK, Son MH, Kaang BK.
    Biochem Biophys Res Commun; 2012 Jan 06; 417(1):558-63. PubMed ID: 22177947
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  • 17. Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.
    Runge S, Schimmer S, Oschmann J, Schiødt CB, Knudsen SM, Jeppesen CB, Madsen K, Lau J, Thøgersen H, Rudolph R.
    Biochemistry; 2007 May 15; 46(19):5830-40. PubMed ID: 17444618
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  • 20. Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.
    Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE.
    J Biol Chem; 2016 Jul 15; 291(29):15119-30. PubMed ID: 27226600
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