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325 related items for PubMed ID: 22144179

  • 1. GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.
    Flügel D, Görlach A, Kietzmann T.
    Blood; 2012 Feb 02; 119(5):1292-301. PubMed ID: 22144179
    [Abstract] [Full Text] [Related]

  • 2. Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
    Cassavaugh JM, Hale SA, Wellman TL, Howe AK, Wong C, Lounsbury KM.
    J Cell Biochem; 2011 Dec 02; 112(12):3882-90. PubMed ID: 21964756
    [Abstract] [Full Text] [Related]

  • 3. Mechanisms of c-myc degradation by nickel compounds and hypoxia.
    Li Q, Kluz T, Sun H, Costa M.
    PLoS One; 2009 Dec 31; 4(12):e8531. PubMed ID: 20046830
    [Abstract] [Full Text] [Related]

  • 4. The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs.
    Liu N, Li H, Li S, Shen M, Xiao N, Chen Y, Wang Y, Wang W, Wang R, Wang Q, Sun J, Wang P.
    J Biol Chem; 2010 Jun 11; 285(24):18858-67. PubMed ID: 20388706
    [Abstract] [Full Text] [Related]

  • 5. Dual regulation of Fbw7 function and oncogenic transformation by Usp28.
    Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Jänicke LA, Diefenbacher ME, Behrens A, Eilers M, Popov N.
    Cell Rep; 2014 Nov 06; 9(3):1099-109. PubMed ID: 25437563
    [Abstract] [Full Text] [Related]

  • 6. FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation.
    Wang R, Wang Y, Liu N, Ren C, Jiang C, Zhang K, Yu S, Chen Y, Tang H, Deng Q, Fu C, Wang Y, Li R, Liu M, Pan W, Wang P.
    Cell Res; 2013 Jun 06; 23(6):803-19. PubMed ID: 23507969
    [Abstract] [Full Text] [Related]

  • 7. Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.
    Nakajima T, Kitagawa K, Ohhata T, Sakai S, Uchida C, Shibata K, Minegishi N, Yumimoto K, Nakayama KI, Masumoto K, Katou F, Niida H, Kitagawa M.
    J Biol Chem; 2015 Apr 17; 290(16):10368-81. PubMed ID: 25670854
    [Abstract] [Full Text] [Related]

  • 8. Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3).
    Kannan MB, Dodard-Friedman I, Blank V.
    J Biol Chem; 2015 Oct 23; 290(43):26292-302. PubMed ID: 26306035
    [Abstract] [Full Text] [Related]

  • 9. Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.
    Diefenbacher ME, Chakraborty A, Blake SM, Mitter R, Popov N, Eilers M, Behrens A.
    Cancer Res; 2015 Apr 01; 75(7):1181-6. PubMed ID: 25716680
    [Abstract] [Full Text] [Related]

  • 10. A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α).
    Bialkowska AB, Liu Y, Nandan MO, Yang VW.
    J Biol Chem; 2014 Feb 28; 289(9):5997-6005. PubMed ID: 24398687
    [Abstract] [Full Text] [Related]

  • 11. Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3β-Dependent Manner.
    Kumar Y, Shukla N, Thacker G, Kapoor I, Lochab S, Bhatt ML, Chattopadhyay N, Sanyal S, Trivedi AK.
    Mol Cancer Res; 2016 Nov 28; 14(11):1097-1109. PubMed ID: 27470268
    [Abstract] [Full Text] [Related]

  • 12. Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.
    Popov N, Herold S, Llamazares M, Schülein C, Eilers M.
    Cell Cycle; 2007 Oct 01; 6(19):2327-31. PubMed ID: 17873522
    [Abstract] [Full Text] [Related]

  • 13. Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1.
    Biswas M, Kwong EK, Park E, Nagra P, Chan JY.
    Exp Cell Res; 2013 Aug 01; 319(13):1922-1931. PubMed ID: 23623971
    [Abstract] [Full Text] [Related]

  • 14. E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation.
    Lochab S, Pal P, Kapoor I, Kanaujiya JK, Sanyal S, Behre G, Trivedi AK.
    Biochim Biophys Acta; 2013 Dec 01; 1833(12):2639-2652. PubMed ID: 23820376
    [Abstract] [Full Text] [Related]

  • 15. Hypoxic inactivation of glycogen synthase kinase-3β promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling.
    Ko YS, Cho SJ, Park J, Choi Y, Lee JS, Youn HD, Kim WH, Kim MA, Park JW, Lee BL.
    APMIS; 2016 Sep 01; 124(9):748-56. PubMed ID: 27365055
    [Abstract] [Full Text] [Related]

  • 16. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
    Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE.
    Proc Natl Acad Sci U S A; 2004 Jun 15; 101(24):9085-90. PubMed ID: 15150404
    [Abstract] [Full Text] [Related]

  • 17. The FBW7-KLF2 axis regulates endothelial functions.
    Zhao Y, Sun Y.
    Cell Res; 2013 Jun 15; 23(6):741-3. PubMed ID: 23567558
    [Abstract] [Full Text] [Related]

  • 18. Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner.
    Flügel D, Görlach A, Michiels C, Kietzmann T.
    Mol Cell Biol; 2007 May 15; 27(9):3253-65. PubMed ID: 17325032
    [Abstract] [Full Text] [Related]

  • 19. Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α.
    Trausch-Azar JS, Abed M, Orian A, Schwartz AL.
    J Cell Physiol; 2015 Apr 15; 230(4):842-52. PubMed ID: 25204433
    [Abstract] [Full Text] [Related]

  • 20. Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells.
    Chen MC, Chen CH, Chuang HC, Kulp SK, Teng CM, Chen CS.
    Hepatology; 2011 Jan 15; 53(1):148-59. PubMed ID: 21254166
    [Abstract] [Full Text] [Related]

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