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422 related items for PubMed ID: 22173835

  • 1. Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
    Misra UK, Pizzo SV.
    J Cell Biochem; 2012 May; 113(5):1488-500. PubMed ID: 22173835
    [Abstract] [Full Text] [Related]

  • 2. Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
    Misra UK, Pizzo SV.
    PLoS One; 2013 May; 8(4):e63150. PubMed ID: 23646189
    [Abstract] [Full Text] [Related]

  • 3. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK, Pizzo SV.
    PLoS One; 2012 May; 7(12):e51735. PubMed ID: 23272152
    [Abstract] [Full Text] [Related]

  • 4. The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
    Misra UK, Kaczowka S, Pizzo SV.
    Cell Signal; 2008 Aug; 20(8):1459-70. PubMed ID: 18495429
    [Abstract] [Full Text] [Related]

  • 5. Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
    Misra UK, Pizzo SV.
    J Biol Chem; 2005 Nov 18; 280(46):38276-89. PubMed ID: 16172130
    [Abstract] [Full Text] [Related]

  • 6. Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
    Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.
    Int J Oncol; 2009 Oct 18; 35(4):731-40. PubMed ID: 19724909
    [Abstract] [Full Text] [Related]

  • 7. Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
    Misra UK, Kaczowka SJ, Pizzo SV.
    Cell Signal; 2008 Jan 18; 20(1):130-8. PubMed ID: 17993260
    [Abstract] [Full Text] [Related]

  • 8. Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition.
    Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA.
    Mol Cancer Ther; 2009 Apr 18; 8(4):742-53. PubMed ID: 19372546
    [Abstract] [Full Text] [Related]

  • 9. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
    Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.
    J Biol Chem; 2007 Aug 31; 282(35):25604-12. PubMed ID: 17599906
    [Abstract] [Full Text] [Related]

  • 10. Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling.
    Namkoong S, Kim CK, Cho YL, Kim JH, Lee H, Ha KS, Choe J, Kim PH, Won MH, Kwon YG, Shim EB, Kim YM.
    Cell Signal; 2009 Jun 31; 21(6):906-15. PubMed ID: 19385062
    [Abstract] [Full Text] [Related]

  • 11. Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.
    Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E.
    Cell Signal; 2009 May 31; 21(5):760-6. PubMed ID: 19167487
    [Abstract] [Full Text] [Related]

  • 12. GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
    Ito H, Ichiyanagi O, Naito S, Bilim VN, Tomita Y, Kato T, Nagaoka A, Tsuchiya N.
    BMC Cancer; 2016 Jul 07; 16():393. PubMed ID: 27387559
    [Abstract] [Full Text] [Related]

  • 13. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.
    Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA.
    Mol Cell Biol; 2009 Mar 07; 29(6):1411-20. PubMed ID: 19114562
    [Abstract] [Full Text] [Related]

  • 14. Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.
    Lee SL, Chou CC, Chuang HC, Hsu EC, Chiu PC, Kulp SK, Byrd JC, Chen CS.
    PLoS One; 2013 Mar 07; 8(6):e67149. PubMed ID: 23840605
    [Abstract] [Full Text] [Related]

  • 15. Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.
    Morrison Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov dos D, Muller WJ, Brantley-Sieders D, Cook RS.
    Cancer Res; 2016 Aug 15; 76(16):4752-64. PubMed ID: 27197158
    [Abstract] [Full Text] [Related]

  • 16. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.
    Kwak HJ, Park KM, Choi HE, Chung KS, Lim HJ, Park HY.
    Cell Signal; 2008 May 15; 20(5):803-14. PubMed ID: 18276108
    [Abstract] [Full Text] [Related]

  • 17. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.
    Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM, Chen J.
    Mol Cell Biol; 2015 Apr 15; 35(7):1299-313. PubMed ID: 25582201
    [Abstract] [Full Text] [Related]

  • 18. Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.
    Kudchodkar SB, Yu Y, Maguire TG, Alwine JC.
    Proc Natl Acad Sci U S A; 2006 Sep 19; 103(38):14182-7. PubMed ID: 16959881
    [Abstract] [Full Text] [Related]

  • 19. IKK interacts with rictor and regulates mTORC2.
    Xu Y, Lai E, Liu J, Lin J, Yang C, Jia C, Li Y, Bai X, Li M.
    Cell Signal; 2013 Nov 19; 25(11):2239-45. PubMed ID: 23872070
    [Abstract] [Full Text] [Related]

  • 20. Raptor-rictor axis in TGFbeta-induced protein synthesis.
    Das F, Ghosh-Choudhury N, Mahimainathan L, Venkatesan B, Feliers D, Riley DJ, Kasinath BS, Choudhury GG.
    Cell Signal; 2008 Feb 19; 20(2):409-23. PubMed ID: 18068336
    [Abstract] [Full Text] [Related]

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