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Journal Abstract Search

269 related items for PubMed ID: 22182429

  • 1. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.
    Hunter FW, Wang J, Patel R, Hsu HL, Hickey AJ, Hay MP, Wilson WR.
    Biochem Pharmacol; 2012 Mar 01; 83(5):574-85. PubMed ID: 22182429
    [Abstract] [Full Text] [Related]

  • 2. The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs.
    Hunter FW, Jaiswal JK, Hurley DG, Liyanage HD, McManaway SP, Gu Y, Richter S, Wang J, Tercel M, Print CG, Wilson WR, Pruijn FB.
    Biochem Pharmacol; 2014 May 15; 89(2):224-35. PubMed ID: 24632291
    [Abstract] [Full Text] [Related]

  • 3. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Johnson KM, Parsons ZD, Barnes CL, Gates KS.
    J Org Chem; 2014 Aug 15; 79(16):7520-31. PubMed ID: 25029663
    [Abstract] [Full Text] [Related]

  • 4. Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.
    Hicks KO, Myint H, Patterson AV, Pruijn FB, Siim BG, Patel K, Wilson WR.
    Int J Radiat Oncol Biol Phys; 2007 Oct 01; 69(2):560-71. PubMed ID: 17869669
    [Abstract] [Full Text] [Related]

  • 5. The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.
    Wang J, Foehrenbacher A, Su J, Patel R, Hay MP, Hicks KO, Wilson WR.
    Clin Cancer Res; 2012 Mar 15; 18(6):1684-95. PubMed ID: 22167409
    [Abstract] [Full Text] [Related]

  • 6. Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A.
    Gu Y, Patterson AV, Atwell GJ, Chernikova SB, Brown JM, Thompson LH, Wilson WR.
    Mol Cancer Ther; 2009 Jun 15; 8(6):1714-23. PubMed ID: 19509245
    [Abstract] [Full Text] [Related]

  • 7. Photodegradation of the benzotriazine 1,4-Di-N-oxide hypoxia-activated prodrug SN30000 in aqueous solution.
    Gu Y, Jaiswal JK, Wang J, Hicks KO, Hay MP, Wilson WR.
    J Pharm Sci; 2014 Nov 15; 103(11):3464-3472. PubMed ID: 25212501
    [Abstract] [Full Text] [Related]

  • 8. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
    Anderson RF, Shinde SS, Hay MP, Denny WA.
    J Am Chem Soc; 2006 Jan 11; 128(1):245-9. PubMed ID: 16390153
    [Abstract] [Full Text] [Related]

  • 9. 1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part III.
    Cerecetto H, González M, Risso M, Saenz P, Olea-Azar C, Bruno AM, Azqueta A, De Ceráin AL, Monge A.
    Arch Pharm (Weinheim); 2004 May 11; 337(5):271-80. PubMed ID: 15095420
    [Abstract] [Full Text] [Related]

  • 10. Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5.
    Wang J, Guise CP, Dachs GU, Phung Y, Hsu AH, Lambie NK, Patterson AV, Wilson WR.
    Biochem Pharmacol; 2014 Oct 15; 91(4):436-46. PubMed ID: 25130546
    [Abstract] [Full Text] [Related]

  • 11. Schedule-dependent potentiation of chemotherapy drugs by the hypoxia-activated prodrug SN30000.
    Mao X, McManaway S, Jaiswal JK, Hong CR, Wilson WR, Hicks KO.
    Cancer Biol Ther; 2019 Oct 15; 20(9):1258-1269. PubMed ID: 31131698
    [Abstract] [Full Text] [Related]

  • 12. Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: a role for NADPH:cytochrome P450 oxidoreductase under hypoxia.
    Guise CP, Wang AT, Theil A, Bridewell DJ, Wilson WR, Patterson AV.
    Biochem Pharmacol; 2007 Sep 15; 74(6):810-20. PubMed ID: 17645874
    [Abstract] [Full Text] [Related]

  • 13. DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.
    Singleton RS, Guise CP, Ferry DM, Pullen SM, Dorie MJ, Brown JM, Patterson AV, Wilson WR.
    Cancer Res; 2009 May 01; 69(9):3884-91. PubMed ID: 19366798
    [Abstract] [Full Text] [Related]

  • 14. Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.
    Su J, Gu Y, Pruijn FB, Smaill JB, Patterson AV, Guise CP, Wilson WR.
    J Biol Chem; 2013 Dec 27; 288(52):37138-53. PubMed ID: 24196959
    [Abstract] [Full Text] [Related]

  • 15. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2003 Jan 02; 46(1):169-82. PubMed ID: 12502371
    [Abstract] [Full Text] [Related]

  • 16. Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Anderson RF, Shinde SS, Hay MP, Gamage SA, Denny WA.
    Org Biomol Chem; 2005 Jun 07; 3(11):2167-74. PubMed ID: 15917906
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and anti-cancer activity of 2,6-disubstituted N-methylpiperidine derivatives and their N-oxides.
    Henderson ND, Plumb JA, Robins DJ, Workman P.
    Anticancer Drug Des; 1996 Sep 07; 11(6):421-38. PubMed ID: 8836108
    [Abstract] [Full Text] [Related]

  • 18. Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
    Guise CP, Abbattista MR, Anderson RF, Li D, Taghipouran R, Tsai A, Lee SJ, Smaill JB, Denny WA, Hay MP, Wilson WR, Hicks KO, Patterson AV.
    Molecules; 2020 Oct 22; 25(21):. PubMed ID: 33105798
    [Abstract] [Full Text] [Related]

  • 19. Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.
    Shen X, Rajapakse A, Gallazzi F, Junnotula V, Fuchs-Knotts T, Glaser R, Gates KS.
    Chem Res Toxicol; 2014 Jan 21; 27(1):111-8. PubMed ID: 24328261
    [Abstract] [Full Text] [Related]

  • 20. Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors.
    Hay MP, Shin HN, Wong WW, Sahimi WW, Vaz ATD, Yadav P, Anderson RF, Hicks KO, Wilson WR.
    Molecules; 2019 Jul 10; 24(14):. PubMed ID: 31295864
    [Abstract] [Full Text] [Related]

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