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Journal Abstract Search

127 related items for PubMed ID: 22182498

  • 1. Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
    Durón SG, Lindstrom A, Bonnefous C, Zhang H, Chen X, Symons KT, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1237-41. PubMed ID: 22182498
    [Abstract] [Full Text] [Related]

  • 2. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2009 May 14; 52(9):3047-62. PubMed ID: 19374401
    [Abstract] [Full Text] [Related]

  • 3. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.
    López Cara LC, Camacho ME, Carrión MD, Tapias V, Gallo MA, Escames G, Acuña-Castroviejo D, Espinosa A, Entrena A.
    Eur J Med Chem; 2009 Jun 14; 44(6):2655-66. PubMed ID: 19117642
    [Abstract] [Full Text] [Related]

  • 4. Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
    Grädler U, Fuchss T, Ulrich WR, Boer R, Strub A, Hesslinger C, Anézo C, Diederichs K, Zaliani A.
    Bioorg Med Chem Lett; 2011 Jul 15; 21(14):4228-32. PubMed ID: 21684157
    [Abstract] [Full Text] [Related]

  • 5. Discovery of a series of aminopiperidines as novel iNOS inhibitors.
    Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE.
    Bioorg Med Chem Lett; 2008 Jan 01; 18(1):336-43. PubMed ID: 18024030
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  • 7. Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones.
    Kravchenko DV, Kysil VM, Tkachenko SE, Maliarchouk S, Okun IM, Ivachtchenko AV.
    Eur J Med Chem; 2005 Dec 01; 40(12):1377-83. PubMed ID: 16169127
    [Abstract] [Full Text] [Related]

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  • 9. Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III).
    Carrión MD, López Cara LC, Camacho ME, Tapias V, Escames G, Acuña-Castroviejo D, Espinosa A, Gallo MA, Entrena A.
    Eur J Med Chem; 2008 Nov 01; 43(11):2579-91. PubMed ID: 18325637
    [Abstract] [Full Text] [Related]

  • 10. 1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence.
    López-Cara LC, Carrión MD, Entrena A, Gallo MA, Espinosa A, López A, Escames G, Acuña-Castroviejo D, Camacho ME.
    Eur J Med Chem; 2012 Apr 01; 50():129-39. PubMed ID: 22336385
    [Abstract] [Full Text] [Related]

  • 11. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
    Hah JM, Martásek P, Roman LJ, Silverman RB.
    J Med Chem; 2003 Apr 24; 46(9):1661-9. PubMed ID: 12699384
    [Abstract] [Full Text] [Related]

  • 12. Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): a structure-activity relationship study.
    Romanski S, Kraus B, Guttentag M, Schlundt W, Rücker H, Adler A, Neudörfl JM, Alberto R, Amslinger S, Schmalz HG.
    Dalton Trans; 2012 Dec 07; 41(45):13862-75. PubMed ID: 22677923
    [Abstract] [Full Text] [Related]

  • 13. Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
    Gahman TC, Herbert MR, Lang H, Thayer A, Symons KT, Nguyen PM, Massari ME, Dozier S, Zhang Y, Sablad M, Rao TS, Noble SA, Shiau AK, Hassig CA.
    Bioorg Med Chem Lett; 2011 Nov 15; 21(22):6888-94. PubMed ID: 21986586
    [Abstract] [Full Text] [Related]

  • 14. Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric oxide synthase (iNOS) inhibitors.
    Suaifan GA, Shehadehh M, Al-Ijel H, Taha MO.
    J Mol Graph Model; 2012 Jul 15; 37():1-26. PubMed ID: 22609742
    [Abstract] [Full Text] [Related]

  • 15. Development of urea and thiourea kynurenamine derivatives: synthesis, molecular modeling, and biological evaluation as nitric oxide synthase inhibitors.
    Chayah M, Carrión MD, Gallo MA, Jiménez R, Duarte J, Camacho ME.
    ChemMedChem; 2015 May 15; 10(5):874-82. PubMed ID: 25801086
    [Abstract] [Full Text] [Related]

  • 16. Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
    Young RJ, Alderton W, Angell AD, Beswick PJ, Brown D, Chambers CL, Crowe MC, Dawson J, Hamlett CC, Hodgson ST, Kleanthous S, Knowles RG, Russell LJ, Stocker R, Woolven JM.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3037-40. PubMed ID: 21482467
    [Abstract] [Full Text] [Related]

  • 17. 1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
    Renton P, Speed J, Maddaford S, Annedi SC, Ramnauth J, Rakhit S, Andrews J.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5301-4. PubMed ID: 21813276
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.
    Liu M, Xin Z, Clampit JE, Wang S, Gum RJ, Haasch DL, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G.
    Bioorg Med Chem Lett; 2006 May 15; 16(10):2590-4. PubMed ID: 16527482
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and biological evaluation of indazole derivatives.
    Claramunt RM, López C, López A, Pérez-Medina C, Pérez-Torralba M, Alkorta I, Elguero J, Escames G, Acuña-Castroviejo D.
    Eur J Med Chem; 2011 Apr 15; 46(4):1439-47. PubMed ID: 21334118
    [Abstract] [Full Text] [Related]

  • 20. Suppressive effects of coumarins from Mammea siamensis on inducible nitric oxide synthase expression in RAW264.7 cells.
    Morikawa T, Sueyoshi M, Chaipech S, Matsuda H, Nomura Y, Yabe M, Matsumoto T, Ninomiya K, Yoshikawa M, Pongpiriyadacha Y, Hayakawa T, Muraoka O.
    Bioorg Med Chem; 2012 Aug 15; 20(16):4968-77. PubMed ID: 22831798
    [Abstract] [Full Text] [Related]

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