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242 related items for PubMed ID: 22194610

  • 1. Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.
    Song H, Wohltmann M, Tan M, Bao S, Ladenson JH, Turk J.
    J Biol Chem; 2012 Feb 17; 287(8):5528-41. PubMed ID: 22194610
    [Abstract] [Full Text] [Related]

  • 2. Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
    Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Song H, Bao S, Ma Z, Turk J.
    Biochemistry; 2004 Feb 03; 43(4):918-30. PubMed ID: 14744135
    [Abstract] [Full Text] [Related]

  • 3. Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.
    Ma Z, Ramanadham S, Wohltmann M, Bohrer A, Hsu FF, Turk J.
    J Biol Chem; 2001 Apr 20; 276(16):13198-208. PubMed ID: 11278673
    [Abstract] [Full Text] [Related]

  • 4. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.
    Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.
    Am J Physiol Endocrinol Metab; 2008 Feb 20; 294(2):E217-29. PubMed ID: 17895289
    [Abstract] [Full Text] [Related]

  • 5. Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes.
    Ali T, Kokotos G, Magrioti V, Bone RN, Mobley JA, Hancock W, Ramanadham S.
    PLoS One; 2013 Feb 20; 8(8):e71748. PubMed ID: 23977134
    [Abstract] [Full Text] [Related]

  • 6. Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.
    Ramanadham S, Song H, Hsu FF, Zhang S, Crankshaw M, Grant GA, Newgard CB, Bao S, Ma Z, Turk J.
    Biochemistry; 2003 Dec 02; 42(47):13929-40. PubMed ID: 14636061
    [Abstract] [Full Text] [Related]

  • 7. Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.
    Lei X, Zhang S, Bohrer A, Ramanadham S.
    J Biol Chem; 2008 Dec 12; 283(50):34819-32. PubMed ID: 18936091
    [Abstract] [Full Text] [Related]

  • 8. Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
    Wang Z, Ramanadham S, Ma ZA, Bao S, Mancuso DJ, Gross RW, Turk J.
    J Biol Chem; 2005 Feb 25; 280(8):6840-9. PubMed ID: 15576376
    [Abstract] [Full Text] [Related]

  • 9. Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.
    Zhao Z, Zhang X, Zhao C, Choi J, Shi J, Song K, Turk J, Ma ZA.
    Endocrinology; 2010 Jul 25; 151(7):3038-48. PubMed ID: 20463052
    [Abstract] [Full Text] [Related]

  • 10. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
    Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S.
    Biochemistry; 2007 Sep 04; 46(35):10170-85. PubMed ID: 17685585
    [Abstract] [Full Text] [Related]

  • 11. Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.
    Song H, Rohrs H, Tan M, Wohltmann M, Ladenson JH, Turk J.
    J Biol Chem; 2010 Oct 29; 285(44):33843-57. PubMed ID: 20732873
    [Abstract] [Full Text] [Related]

  • 12. Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.
    Barbour SE, Nguyen PT, Park M, Emani B, Lei X, Kambalapalli M, Shultz JC, Wijesinghe D, Chalfant CE, Ramanadham S.
    J Biol Chem; 2015 Apr 24; 290(17):11021-31. PubMed ID: 25762722
    [Abstract] [Full Text] [Related]

  • 13. Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.
    Xie Z, Gong MC, Su W, Turk J, Guo Z.
    J Biol Chem; 2007 Aug 31; 282(35):25278-89. PubMed ID: 17613534
    [Abstract] [Full Text] [Related]

  • 14. The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.
    Pattabiraman PP, Lih FB, Tomer KB, Rao PV.
    Am J Physiol Cell Physiol; 2012 Apr 01; 302(7):C979-91. PubMed ID: 22237407
    [Abstract] [Full Text] [Related]

  • 15. Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.
    Ma Z, Zhang S, Turk J, Ramanadham S.
    Am J Physiol Endocrinol Metab; 2002 Apr 01; 282(4):E820-33. PubMed ID: 11882502
    [Abstract] [Full Text] [Related]

  • 16. Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.
    Lei X, Barbour SE, Ramanadham S.
    Biochimie; 2010 Jun 01; 92(6):627-37. PubMed ID: 20083151
    [Abstract] [Full Text] [Related]

  • 17. Complement-mediated activation of calcium-independent phospholipase A2γ: role of protein kinases and phosphorylation.
    Elimam H, Papillon J, Takano T, Cybulsky AV.
    J Biol Chem; 2013 Feb 08; 288(6):3871-85. PubMed ID: 23258543
    [Abstract] [Full Text] [Related]

  • 18. Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis.
    Song H, Wohltmann M, Tan M, Ladenson JH, Turk J.
    J Biol Chem; 2014 May 16; 289(20):14194-210. PubMed ID: 24648512
    [Abstract] [Full Text] [Related]

  • 19. Different MAPK signal transduction pathways play different roles in the impairment of glucose‑stimulated insulin secretion in response to IL‑1β.
    Ou Y, Zheng Z, Niu B, Su J, Su H.
    Mol Med Rep; 2020 Oct 16; 22(4):2973-2980. PubMed ID: 32945406
    [Abstract] [Full Text] [Related]

  • 20. Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells.
    Bao S, Jin C, Zhang S, Turk J, Ma Z, Ramanadham S.
    Diabetes; 2004 Feb 16; 53 Suppl 1(0 1):S186-9. PubMed ID: 14749286
    [Abstract] [Full Text] [Related]

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