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313 related items for PubMed ID: 22204739

  • 1. Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.
    Baraldi PG, Saponaro G, Aghazadeh Tabrizi M, Baraldi S, Romagnoli R, Moorman AR, Varani K, Borea PA, Preti D.
    Bioorg Med Chem; 2012 Jan 15; 20(2):1046-59. PubMed ID: 22204739
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.
    Baraldi PG, Fruttarolo F, Tabrizi MA, Preti D, Romagnoli R, El-Kashef H, Moorman A, Varani K, Gessi S, Merighi S, Borea PA.
    J Med Chem; 2003 Mar 27; 46(7):1229-41. PubMed ID: 12646033
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  • 4. The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.
    Cheong SL, Dolzhenko A, Kachler S, Paoletta S, Federico S, Cacciari B, Dolzhenko A, Klotz KN, Moro S, Spalluto G, Pastorin G.
    J Med Chem; 2010 Apr 22; 53(8):3361-75. PubMed ID: 20307065
    [Abstract] [Full Text] [Related]

  • 5. Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.
    Federico S, Ciancetta A, Porta N, Redenti S, Pastorin G, Cacciari B, Klotz KN, Moro S, Spalluto G.
    J Med Chem; 2014 Jul 24; 57(14):6210-25. PubMed ID: 24972108
    [Abstract] [Full Text] [Related]

  • 6. Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.
    Michielan L, Bolcato C, Federico S, Cacciari B, Bacilieri M, Klotz KN, Kachler S, Pastorin G, Cardin R, Sperduti A, Spalluto G, Moro S.
    Bioorg Med Chem; 2009 Jul 15; 17(14):5259-74. PubMed ID: 19501513
    [Abstract] [Full Text] [Related]

  • 7. Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.
    Baraldi PG, Cacciari B, Spalluto G, Pineda de las Infantas y Villatoro MJ, Zocchi C, Dionisotti S, Ongini E.
    J Med Chem; 1996 Mar 01; 39(5):1164-71. PubMed ID: 8676354
    [Abstract] [Full Text] [Related]

  • 8. Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.
    Federico S, Ciancetta A, Sabbadin D, Paoletta S, Pastorin G, Cacciari B, Klotz KN, Moro S, Spalluto G.
    J Med Chem; 2012 Nov 26; 55(22):9654-68. PubMed ID: 23098605
    [Abstract] [Full Text] [Related]

  • 9. Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?
    Cheong SL, Dolzhenko AV, Paoletta S, Lee EP, Kachler S, Federico S, Klotz KN, Dolzhenko AV, Spalluto G, Moro S, Pastorin G.
    Bioorg Med Chem; 2011 Oct 15; 19(20):6120-34. PubMed ID: 21908194
    [Abstract] [Full Text] [Related]

  • 10. [1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype.
    Federico S, Margiotta E, Salmaso V, Pastorin G, Kachler S, Klotz KN, Moro S, Spalluto G.
    Eur J Med Chem; 2018 Sep 05; 157():837-851. PubMed ID: 30144700
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.
    Baraldi PG, Cacciari B, Spalluto G, Bergonzoni M, Dionisotti S, Ongini E, Varani K, Borea PA.
    J Med Chem; 1998 Jun 04; 41(12):2126-33. PubMed ID: 9622554
    [Abstract] [Full Text] [Related]

  • 12. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists.
    Cheong SL, Federico S, Venkatesan G, Paira P, Shao YM, Spalluto G, Yap CW, Pastorin G.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):2898-905. PubMed ID: 21511471
    [Abstract] [Full Text] [Related]

  • 13. 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
    Lenzi O, Colotta V, Catarzi D, Varano F, Poli D, Filacchioni G, Varani K, Vincenzi F, Borea PA, Paoletta S, Morizzo E, Moro S.
    J Med Chem; 2009 Dec 10; 52(23):7640-52. PubMed ID: 19743865
    [Abstract] [Full Text] [Related]

  • 14. 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A₁ and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.
    Squarcialupi L, Colotta V, Catarzi D, Varano F, Betti M, Varani K, Vincenzi F, Borea PA, Porta N, Ciancetta A, Moro S.
    Eur J Med Chem; 2014 Sep 12; 84():614-27. PubMed ID: 25063944
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.
    Pastorin G, Da Ros T, Bolcato C, Montopoli C, Moro S, Cacciari B, Baraldi PG, Varani K, Borea PA, Spalluto G.
    J Med Chem; 2006 Mar 09; 49(5):1720-9. PubMed ID: 16509587
    [Abstract] [Full Text] [Related]

  • 16. One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists.
    Baraldi PG, Baraldi S, Saponaro G, Aghazadeh Tabrizi M, Romagnoli R, Ruggiero E, Vincenzi F, Borea PA, Varani K.
    J Med Chem; 2015 Jul 09; 58(13):5355-60. PubMed ID: 26046697
    [Abstract] [Full Text] [Related]

  • 17. QSAR of adenosine receptor antagonists: Exploring physicochemical requirements for binding of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives with human adenosine A(3) receptor subtype.
    Pran Kishore D, Balakumar C, Raghuram Rao A, Roy PP, Roy K.
    Bioorg Med Chem Lett; 2011 Jan 15; 21(2):818-23. PubMed ID: 21163647
    [Abstract] [Full Text] [Related]

  • 18. Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.
    Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Moro S, Klotz KN, Leung E, Varani K, Gessi S, Merighi S, Borea PA.
    J Med Chem; 2000 Dec 14; 43(25):4768-80. PubMed ID: 11123985
    [Abstract] [Full Text] [Related]

  • 19. Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.
    Giovannoni MP, Vergelli C, Cilibrizzi A, Crocetti L, Biancalani C, Graziano A, Dal Piaz V, Loza MI, Cadavid MI, Díaz JL, Gavaldà A.
    Bioorg Med Chem; 2010 Nov 15; 18(22):7890-9. PubMed ID: 20937560
    [Abstract] [Full Text] [Related]

  • 20. Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists.
    Redenti S, Ciancetta A, Pastorin G, Cacciari B, Moro S, Spalluto G, Federico S.
    Curr Top Med Chem; 2016 Nov 15; 16(28):3224-3257. PubMed ID: 27150365
    [Abstract] [Full Text] [Related]

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