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Journal Abstract Search

182 related items for PubMed ID: 22209458

  • 1. Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.
    Roughley SD, Browne H, Macias AT, Benwell K, Brooks T, D'Alessandro J, Daniels Z, Dugdale S, Francis G, Gibbons B, Hart T, Haymes T, Kennett G, Lightowler S, Matassova N, Mansell H, Merrett A, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Simmonite H, Tan K, Walls SB, Wong M.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):901-6. PubMed ID: 22209458
    [Abstract] [Full Text] [Related]

  • 2. Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
    Hart T, Macias AT, Benwell K, Brooks T, D'Alessandro J, Dokurno P, Francis G, Gibbons B, Haymes T, Kennett G, Lightowler S, Mansell H, Matassova N, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Walls S, Wong M, Roughley S.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4241-4. PubMed ID: 19515560
    [Abstract] [Full Text] [Related]

  • 3. Structure based design of novel irreversible FAAH inhibitors.
    Wang JL, Bowen SJ, Schweitzer BA, Madsen HM, McDonald J, Pelc MJ, Tenbrink RE, Beidler D, Thorarensen A.
    Bioorg Med Chem Lett; 2009 Oct 15; 19(20):5970-4. PubMed ID: 19765986
    [Abstract] [Full Text] [Related]

  • 4. Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
    Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2492-6. PubMed ID: 21392988
    [Abstract] [Full Text] [Related]

  • 5. Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase.
    Keith JM, Jones W, Pierce JM, Seierstad M, Palmer JA, Webb M, Karbarz M, Scott BP, Wilson SJ, Luo L, Wennerholm M, Chang L, Rizzolio M, Rynberg R, Chaplan S, Guy Breitenbucher J.
    Bioorg Med Chem Lett; 2020 Oct 15; 30(20):127463. PubMed ID: 32784090
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
    Morera E, De Petrocellis L, Morera L, Moriello AS, Ligresti A, Nalli M, Woodward DF, Di Marzo V, Ortar G.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6806-9. PubMed ID: 19875281
    [Abstract] [Full Text] [Related]

  • 7. Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
    Tichenor MS, Keith JM, Jones WM, Pierce JM, Merit J, Hawryluk N, Seierstad M, Palmer JA, Webb M, Karbarz MJ, Wilson SJ, Wennerholm ML, Woestenborghs F, Beerens D, Luo L, Brown SM, Boeck MD, Chaplan SR, Breitenbucher JG.
    Bioorg Med Chem Lett; 2012 Dec 15; 22(24):7357-62. PubMed ID: 23141911
    [Abstract] [Full Text] [Related]

  • 8. Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase.
    Keith JM, Jones WM, Pierce JM, Seierstad M, Palmer JA, Webb M, Karbarz MJ, Scott BP, Wilson SJ, Luo L, Wennerholm ML, Chang L, Brown SM, Rizzolio M, Rynberg R, Chaplan SR, Breitenbucher JG.
    Bioorg Med Chem Lett; 2014 Feb 01; 24(3):737-41. PubMed ID: 24433863
    [Abstract] [Full Text] [Related]

  • 9. The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.
    Keith JM, Tichenor MS, Apodaca RL, Xiao W, Jones WM, Seierstad M, Pierce JM, Palmer JA, Webb M, Karbarz MJ, Scott BP, Wilson SJ, Wennerholm ML, Rizzolio M, Rynberg R, Chaplan SR, Breitenbucher JG.
    Bioorg Med Chem Lett; 2016 Jul 01; 26(13):3109-3114. PubMed ID: 27189675
    [Abstract] [Full Text] [Related]

  • 10. Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
    Vincent F, Nguyen MT, Emerling DE, Kelly MG, Duncton MA.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6793-6. PubMed ID: 19850474
    [Abstract] [Full Text] [Related]

  • 11. Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
    Johnson DS, Ahn K, Kesten S, Lazerwith SE, Song Y, Morris M, Fay L, Gregory T, Stiff C, Dunbar JB, Liimatta M, Beidler D, Smith S, Nomanbhoy TK, Cravatt BF.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2865-9. PubMed ID: 19386497
    [Abstract] [Full Text] [Related]

  • 12. Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors.
    Deplano A, Cipriano M, Moraca F, Novellino E, Catalanotti B, Fowler CJ, Onnis V.
    J Enzyme Inhib Med Chem; 2019 Dec 15; 34(1):562-576. PubMed ID: 30688118
    [Abstract] [Full Text] [Related]

  • 13. N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors.
    Sunduru N, Svensson M, Cipriano M, Marwaha S, Andersson CD, Svensson R, Fowler CJ, Elofsson M.
    J Enzyme Inhib Med Chem; 2017 Dec 15; 32(1):513-521. PubMed ID: 28114819
    [Abstract] [Full Text] [Related]

  • 14. Novel propanamides as fatty acid amide hydrolase inhibitors.
    Deplano A, Morgillo CM, Demurtas M, Björklund E, Cipriano M, Svensson M, Hashemian S, Smaldone G, Pedone E, Luque FJ, Cabiddu MG, Novellino E, Fowler CJ, Catalanotti B, Onnis V.
    Eur J Med Chem; 2017 Aug 18; 136():523-542. PubMed ID: 28535469
    [Abstract] [Full Text] [Related]

  • 15. Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
    Lau JF, Jeppesen CB, Rimvall K, Hohlweg R.
    Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5303-8. PubMed ID: 16908150
    [Abstract] [Full Text] [Related]

  • 16. 1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.
    Zahov S, Garzinsky D, Hanekamp W, Lehr M.
    Bioorg Med Chem; 2017 Feb 01; 25(3):825-837. PubMed ID: 27989417
    [Abstract] [Full Text] [Related]

  • 17. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.
    Muccioli GG, Fazio N, Scriba GK, Poppitz W, Cannata F, Poupaert JH, Wouters J, Lambert DM.
    J Med Chem; 2006 Jan 12; 49(1):417-25. PubMed ID: 16392827
    [Abstract] [Full Text] [Related]

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  • 19. 1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: bioisosteric replacement of the carboxylic acid moiety.
    Althaus J, Hake T, Hanekamp W, Lehr M.
    J Enzyme Inhib Med Chem; 2016 Jan 12; 31(sup1):131-140. PubMed ID: 27162011
    [Abstract] [Full Text] [Related]

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