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Journal Abstract Search

689 related items for PubMed ID: 22228214

  • 1. Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.
    Chen Y, Jin JY, Mukadam S, Malhi V, Kenny JR.
    Biopharm Drug Dispos; 2012 Mar; 33(2):85-98. PubMed ID: 22228214
    [Abstract] [Full Text] [Related]

  • 2. From preclinical to human--prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example.
    Sinha VK, Snoeys J, Osselaer NV, Peer AV, Mackie C, Heald D.
    Biopharm Drug Dispos; 2012 Mar; 33(2):111-21. PubMed ID: 22383166
    [Abstract] [Full Text] [Related]

  • 3. Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events.
    Shaffer CL, Scialis RJ, Rong H, Obach RS.
    Biopharm Drug Dispos; 2012 Mar; 33(2):72-84. PubMed ID: 22213407
    [Abstract] [Full Text] [Related]

  • 4. Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery.
    Lüpfert C, Reichel A.
    Chem Biodivers; 2005 Nov; 2(11):1462-86. PubMed ID: 17191947
    [Abstract] [Full Text] [Related]

  • 5. Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions.
    Greupink R, Schreurs M, Benne MS, Huisman MT, Russel FG.
    Eur J Pharm Sci; 2013 Aug 16; 49(5):819-28. PubMed ID: 23806476
    [Abstract] [Full Text] [Related]

  • 6. Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?
    Bouzom F, Ball K, Perdaems N, Walther B.
    Biopharm Drug Dispos; 2012 Mar 16; 33(2):55-71. PubMed ID: 22228149
    [Abstract] [Full Text] [Related]

  • 7. PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach.
    Poulin P, Jones RD, Jones HM, Gibson CR, Rowland M, Chien JY, Ring BJ, Adkison KK, Ku MS, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Yates JW.
    J Pharm Sci; 2011 Oct 16; 100(10):4127-57. PubMed ID: 21541937
    [Abstract] [Full Text] [Related]

  • 8. Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.
    Heikkinen AT, Baneyx G, Caruso A, Parrott N.
    Eur J Pharm Sci; 2012 Sep 29; 47(2):375-86. PubMed ID: 22759901
    [Abstract] [Full Text] [Related]

  • 9. Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
    Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, Tate SC, El-Kattan A, Houston JB, Galetin A, Fenner KS.
    Drug Metab Dispos; 2012 May 29; 40(5):1007-17. PubMed ID: 22344703
    [Abstract] [Full Text] [Related]

  • 10. PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance.
    Ring BJ, Chien JY, Adkison KK, Jones HM, Rowland M, Jones RD, Yates JW, Ku MS, Gibson CR, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Poulin P.
    J Pharm Sci; 2011 Oct 29; 100(10):4090-110. PubMed ID: 21541938
    [Abstract] [Full Text] [Related]

  • 11. Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim®.
    Willmann S, Thelen K, Lippert J.
    J Pharm Pharmacol; 2012 Jul 29; 64(7):997-1007. PubMed ID: 22686345
    [Abstract] [Full Text] [Related]

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  • 13. PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: prediction of plasma concentration-time profiles in human from in vivo preclinical data by using the Wajima approach.
    Vuppugalla R, Marathe P, He H, Jones RD, Yates JW, Jones HM, Gibson CR, Chien JY, Ring BJ, Adkison KK, Ku MS, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Poulin P.
    J Pharm Sci; 2011 Oct 29; 100(10):4111-26. PubMed ID: 21480234
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  • 16. Development of a hybrid physiologically based pharmacokinetic model with drug-specific scaling factors in rat to improve prediction of human pharmacokinetics.
    Sayama H, Komura H, Kogayu M, Iwaki M.
    J Pharm Sci; 2013 Nov 29; 102(11):4193-204. PubMed ID: 24018828
    [Abstract] [Full Text] [Related]

  • 17. Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico-in vivo extrapolation and physiologically-based pharmacokinetic modeling approach.
    Malmborg J, Ploeger BA.
    J Pharmacol Toxicol Methods; 2013 Nov 29; 67(3):203-13. PubMed ID: 23280406
    [Abstract] [Full Text] [Related]

  • 18. Evaluation of an integrated in vitro-in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability.
    Cai H, Stoner C, Reddy A, Freiwald S, Smith D, Winters R, Stankovic C, Surendran N.
    Int J Pharm; 2006 Feb 03; 308(1-2):133-9. PubMed ID: 16352407
    [Abstract] [Full Text] [Related]

  • 19. Physiologically based pharmacokinetics (PBPK).
    Espié P, Tytgat D, Sargentini-Maier ML, Poggesi I, Watelet JB.
    Drug Metab Rev; 2009 Feb 03; 41(3):391-407. PubMed ID: 19601719
    [Abstract] [Full Text] [Related]

  • 20. Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!
    Rostami-Hodjegan A, Tamai I, Pang KS.
    Biopharm Drug Dispos; 2012 Mar 03; 33(2):47-50. PubMed ID: 22351594
    [No Abstract] [Full Text] [Related]

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