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749 related items for PubMed ID: 22230479

  • 1. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3.
    Chen KF, Chen HL, Liu CY, Tai WT, Ichikawa K, Chen PJ, Cheng AL.
    Biochem Pharmacol; 2012 Mar 15; 83(6):769-77. PubMed ID: 22230479
    [Abstract] [Full Text] [Related]

  • 2. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3.
    Tai WT, Cheng AL, Shiau CW, Liu CY, Ko CH, Lin MW, Chen PJ, Chen KF.
    Mol Cancer Ther; 2012 Feb 15; 11(2):452-63. PubMed ID: 22180308
    [Abstract] [Full Text] [Related]

  • 3. A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation.
    Chen KF, Su JC, Liu CY, Huang JW, Chen KC, Chen WL, Tai WT, Shiau CW.
    Cancer Lett; 2012 Aug 01; 321(1):27-35. PubMed ID: 22465052
    [Abstract] [Full Text] [Related]

  • 4. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3.
    Chen KF, Tai WT, Liu TH, Huang HP, Lin YC, Shiau CW, Li PK, Chen PJ, Cheng AL.
    Clin Cancer Res; 2010 Nov 01; 16(21):5189-99. PubMed ID: 20884624
    [Abstract] [Full Text] [Related]

  • 5. Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis.
    Kusaba M, Nakao K, Goto T, Nishimura D, Kawashimo H, Shibata H, Motoyoshi Y, Taura N, Ichikawa T, Hamasaki K, Eguchi K.
    J Hepatol; 2007 Oct 01; 47(4):546-55. PubMed ID: 17602782
    [Abstract] [Full Text] [Related]

  • 6. Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody.
    Chen KF, Chen HL, Shiau CW, Liu CY, Chu PY, Tai WT, Ichikawa K, Chen PJ, Cheng AL.
    Br J Pharmacol; 2013 Feb 01; 168(3):658-72. PubMed ID: 22978563
    [Abstract] [Full Text] [Related]

  • 7. Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3.
    Huang CY, Lin CS, Tai WT, Hsieh CY, Shiau CW, Cheng AL, Chen KF.
    Int J Radiat Oncol Biol Phys; 2013 Jul 01; 86(3):456-62. PubMed ID: 23474115
    [Abstract] [Full Text] [Related]

  • 8. The cyclin-dependent kinase inhibitor flavopiridol sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis.
    Miyashita K, Shiraki K, Fuke H, Inoue T, Yamanaka Y, Yamaguchi Y, Yamamoto N, Ito K, Sugimoto K, Nakano T.
    Int J Mol Med; 2006 Aug 01; 18(2):249-56. PubMed ID: 16820931
    [Abstract] [Full Text] [Related]

  • 9. Dovitinib Acts As a Novel Radiosensitizer in Hepatocellular Carcinoma by Targeting SHP-1/STAT3 Signaling.
    Huang CY, Tai WT, Wu SY, Shih CT, Chen MH, Tsai MH, Kuo CW, Shiau CW, Hung MH, Chen KF.
    Int J Radiat Oncol Biol Phys; 2016 Jun 01; 95(2):761-71. PubMed ID: 26960749
    [Abstract] [Full Text] [Related]

  • 10. A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3.
    Huang CY, Tai WT, Hsieh CY, Hsu WM, Lai YJ, Chen LJ, Shiau CW, Chen KF.
    Cancer Lett; 2014 Jul 28; 349(2):136-43. PubMed ID: 24735751
    [Abstract] [Full Text] [Related]

  • 11. Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: involvement of Ca(2+) influx.
    Moon DO, Kang CH, Kang SH, Choi YH, Hyun JW, Chang WY, Kang HK, Koh YS, Maeng YH, Kim YR, Kim GY.
    Toxicol Appl Pharmacol; 2012 Feb 15; 259(1):87-95. PubMed ID: 22200406
    [Abstract] [Full Text] [Related]

  • 12. Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.
    Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G.
    J Cell Physiol; 2012 May 15; 227(5):2184-95. PubMed ID: 21792937
    [Abstract] [Full Text] [Related]

  • 13. COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis.
    Yamanaka Y, Shiraki K, Inoue T, Miyashita K, Fuke H, Yamaguchi Y, Yamamoto N, Ito K, Sugimoto K, Nakano T.
    Int J Mol Med; 2006 Jul 15; 18(1):41-7. PubMed ID: 16786154
    [Abstract] [Full Text] [Related]

  • 14. Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation.
    Kim JY, Kim EH, Park SS, Lim JH, Kwon TK, Choi KS.
    J Cell Biochem; 2008 Dec 15; 105(6):1386-98. PubMed ID: 18980244
    [Abstract] [Full Text] [Related]

  • 15. Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction.
    Schulze-Bergkamen H, Fleischer B, Schuchmann M, Weber A, Weinmann A, Krammer PH, Galle PR.
    BMC Cancer; 2006 Oct 02; 6():232. PubMed ID: 17014711
    [Abstract] [Full Text] [Related]

  • 16. ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein.
    Wang G, Zhan Y, Wang H, Li W.
    Cancer Chemother Pharmacol; 2012 Mar 02; 69(3):799-805. PubMed ID: 22037880
    [Abstract] [Full Text] [Related]

  • 17. Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels.
    Lu M, Strohecker A, Chen F, Kwan T, Bosman J, Jordan VC, Cryns VL.
    Clin Cancer Res; 2008 May 15; 14(10):3168-76. PubMed ID: 18483385
    [Abstract] [Full Text] [Related]

  • 18. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma.
    Tai WT, Cheng AL, Shiau CW, Huang HP, Huang JW, Chen PJ, Chen KF.
    J Hepatol; 2011 Nov 15; 55(5):1041-8. PubMed ID: 21354226
    [Abstract] [Full Text] [Related]

  • 19. Cisplatin sensitizes human hepatocellular carcinoma cells, but not hepatocytes and mesenchymal stem cells, to TRAIL within a therapeutic window partially depending on the upregulation of DR5.
    Zhang B, Shan H, Li D, Li ZR, Zhu KS, Jiang ZB, Huang MS.
    Oncol Rep; 2011 Feb 15; 25(2):461-8. PubMed ID: 21152876
    [Abstract] [Full Text] [Related]

  • 20. 5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells.
    Yang JF, Cao JG, Tian L, Liu F.
    Cancer Chemother Pharmacol; 2012 Jan 15; 69(1):195-206. PubMed ID: 21660448
    [Abstract] [Full Text] [Related]

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