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304 related items for PubMed ID: 22231124

  • 1. The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways.
    Favaro E, Granata R, Miceli I, Baragli A, Settanni F, Cavallo Perin P, Ghigo E, Camussi G, Zanone MM.
    Diabetologia; 2012 Apr; 55(4):1058-70. PubMed ID: 22231124
    [Abstract] [Full Text] [Related]

  • 2. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.
    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.
    Endocrinology; 2007 Feb; 148(2):512-29. PubMed ID: 17068144
    [Abstract] [Full Text] [Related]

  • 3. Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.
    Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.
    Diabetes; 2008 Apr; 57(4):967-79. PubMed ID: 18162507
    [Abstract] [Full Text] [Related]

  • 4. Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells.
    Chung H, Seo S, Moon M, Park S.
    J Endocrinol; 2008 Sep; 198(3):511-21. PubMed ID: 18541646
    [Abstract] [Full Text] [Related]

  • 5. Durable islet effects on insulin secretion and protein kinase A expression following exendin-4 treatment of high-fat diet-fed mice.
    Winzell MS, Ahrén B.
    J Mol Endocrinol; 2008 Feb; 40(2):93-100. PubMed ID: 18234911
    [Abstract] [Full Text] [Related]

  • 6. Ghrelin gene products rescue cultured adult rat hippocampal neural stem cells from high glucose insult.
    Kim S, Kim C, Park S.
    J Mol Endocrinol; 2016 Oct; 57(3):171-84. PubMed ID: 27530317
    [Abstract] [Full Text] [Related]

  • 7. Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A.
    Oeseburg H, de Boer RA, Buikema H, van der Harst P, van Gilst WH, Silljé HH.
    Arterioscler Thromb Vasc Biol; 2010 Jul; 30(7):1407-14. PubMed ID: 20448207
    [Abstract] [Full Text] [Related]

  • 8. Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line.
    Wei Q, Sun YQ, Zhang J.
    Peptides; 2012 Sep; 37(1):18-24. PubMed ID: 22776329
    [Abstract] [Full Text] [Related]

  • 9. Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling.
    Namkoong S, Kim CK, Cho YL, Kim JH, Lee H, Ha KS, Choe J, Kim PH, Won MH, Kwon YG, Shim EB, Kim YM.
    Cell Signal; 2009 Jun; 21(6):906-15. PubMed ID: 19385062
    [Abstract] [Full Text] [Related]

  • 10. Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress.
    He J, Wang C, Sun Y, Lu B, Cui J, Dong N, Zhang M, Liu Y, Yu B.
    Int J Mol Med; 2016 Apr; 37(4):889-900. PubMed ID: 26935620
    [Abstract] [Full Text] [Related]

  • 11. Calcineurin signaling regulates human islet {beta}-cell survival.
    Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De León DD, Naji A, Kushner JA, Stoffers DA.
    J Biol Chem; 2010 Dec 17; 285(51):40050-9. PubMed ID: 20943662
    [Abstract] [Full Text] [Related]

  • 12. Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway.
    Favaro E, Miceli I, Bussolati B, Schmitt-Ney M, Cavallo Perin P, Camussi G, Zanone MM.
    Am J Pathol; 2008 Aug 17; 173(2):442-50. PubMed ID: 18599614
    [Abstract] [Full Text] [Related]

  • 13. Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells.
    Wang L, Chen Q, Li G, Ke D.
    Peptides; 2012 Jan 17; 33(1):92-100. PubMed ID: 22100225
    [Abstract] [Full Text] [Related]

  • 14. Ghrelin regulates the proliferation and apoptosis of high glucose-induced islet cells through the PI3K-Akt signaling pathway.
    Zang P, Yang C, Lei H, Guo Q, Wang W, Shao J.
    Cell Biol Int; 2023 Apr 17; 47(4):768-775. PubMed ID: 36718083
    [Abstract] [Full Text] [Related]

  • 15. Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
    Baragli A, Ghè C, Arnoletti E, Granata R, Ghigo E, Muccioli G.
    Biochim Biophys Acta; 2011 Jun 17; 1811(6):386-96. PubMed ID: 21435395
    [Abstract] [Full Text] [Related]

  • 16. Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involving β-catenin.
    Wu X, Li S, Xue P, Li Y.
    Exp Cell Res; 2017 Nov 15; 360(2):281-291. PubMed ID: 28919123
    [Abstract] [Full Text] [Related]

  • 17. AG and UAG induce β-casein expression via activation of ERK1/2 and AKT pathways.
    Li S, Liu J, Lv Q, Zhang C, Xu S, Yang D, Huang B, Zeng Y, Gao Y, Wang W.
    J Mol Endocrinol; 2016 Apr 15; 56(3):213-25. PubMed ID: 26873999
    [Abstract] [Full Text] [Related]

  • 18. Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.
    Granata R, Volante M, Settanni F, Gauna C, Ghé C, Annunziata M, Deidda B, Gesmundo I, Abribat T, van der Lely AJ, Muccioli G, Ghigo E, Papotti M.
    J Mol Endocrinol; 2010 Jul 15; 45(1):9-17. PubMed ID: 20382773
    [Abstract] [Full Text] [Related]

  • 19. Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway.
    El-Kott AF, Shati AA, Al-Kahtani MA, Alqahtani S.
    Anal Cell Pathol (Amst); 2019 Jul 15; 2019():9627810. PubMed ID: 31360627
    [Abstract] [Full Text] [Related]

  • 20. Glucagon-like peptide-1 receptor activation inhibits growth and augments apoptosis in murine CT26 colon cancer cells.
    Koehler JA, Kain T, Drucker DJ.
    Endocrinology; 2011 Sep 15; 152(9):3362-72. PubMed ID: 21771884
    [Abstract] [Full Text] [Related]

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