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384 related items for PubMed ID: 22245121

  • 1. Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR.
    Elcombe CR, Elcombe BM, Foster JR, Chang SC, Ehresman DJ, Butenhoff JL.
    Toxicology; 2012 Mar 11; 293(1-3):16-29. PubMed ID: 22245121
    [Abstract] [Full Text] [Related]

  • 2. Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate.
    Elcombe CR, Elcombe BM, Foster JR, Chang SC, Ehresman DJ, Noker PE, Butenhoff JL.
    Toxicology; 2012 Mar 11; 293(1-3):30-40. PubMed ID: 22239858
    [Abstract] [Full Text] [Related]

  • 3. Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats.
    Butenhoff JL, Chang SC, Olsen GW, Thomford PJ.
    Toxicology; 2012 Mar 11; 293(1-3):1-15. PubMed ID: 22266392
    [Abstract] [Full Text] [Related]

  • 4. Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR.
    Elcombe CR, Elcombe BM, Foster JR, Farrar DG, Jung R, Chang SC, Kennedy GL, Butenhoff JL.
    Arch Toxicol; 2010 Oct 11; 84(10):787-98. PubMed ID: 20614104
    [Abstract] [Full Text] [Related]

  • 5. The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice.
    Su S, Billy LJ, Chang S, Gonzalez FJ, Patterson AD, Peters JM.
    Toxicology; 2022 Jan 15; 465():153056. PubMed ID: 34861291
    [Abstract] [Full Text] [Related]

  • 6. Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats.
    Seacat AM, Thomford PJ, Hansen KJ, Clemen LA, Eldridge SR, Elcombe CR, Butenhoff JL.
    Toxicology; 2003 Feb 01; 183(1-3):117-31. PubMed ID: 12504346
    [Abstract] [Full Text] [Related]

  • 7. Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.
    Ren H, Vallanat B, Nelson DM, Yeung LWY, Guruge KS, Lam PKS, Lehman-McKeeman LD, Corton JC.
    Reprod Toxicol; 2009 Jun 01; 27(3-4):266-277. PubMed ID: 19162173
    [Abstract] [Full Text] [Related]

  • 8. Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation.
    Tinwell H, Rouquié D, Schorsch F, Geter D, Wason S, Bars R.
    Regul Toxicol Pharmacol; 2014 Dec 01; 70(3):648-58. PubMed ID: 25305127
    [Abstract] [Full Text] [Related]

  • 9. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression.
    Chang SC, Ehresman DJ, Bjork JA, Wallace KB, Parker GA, Stump DG, Butenhoff JL.
    Reprod Toxicol; 2009 Jun 01; 27(3-4):387-399. PubMed ID: 19429409
    [Abstract] [Full Text] [Related]

  • 10. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Toxicology; 2018 May 01; 400-401():20-27. PubMed ID: 29548889
    [Abstract] [Full Text] [Related]

  • 11. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.
    Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.
    Xenobiotica; 2019 Feb 01; 49(2):227-238. PubMed ID: 29424600
    [Abstract] [Full Text] [Related]

  • 12. Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
    Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.
    PLoS One; 2013 Feb 01; 8(4):e61802. PubMed ID: 23626729
    [Abstract] [Full Text] [Related]

  • 13. Induction of apoptosis and CYP4A1 expression in Sprague-Dawley rats exposed to low doses of perfluorooctane sulfonate.
    Kim HS, Jun Kwack S, Sik Han E, Seok Kang T, Hee Kim S, Young Han S.
    J Toxicol Sci; 2011 Apr 01; 36(2):201-10. PubMed ID: 21467747
    [Abstract] [Full Text] [Related]

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  • 15. The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor.
    Wyde ME, Bartolucci E, Ueda A, Zhang H, Yan B, Negishi M, You L.
    Mol Pharmacol; 2003 Aug 01; 64(2):474-81. PubMed ID: 12869653
    [Abstract] [Full Text] [Related]

  • 16. Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis.
    Cui L, Zhou QF, Liao CY, Fu JJ, Jiang GB.
    Arch Environ Contam Toxicol; 2009 Feb 01; 56(2):338-49. PubMed ID: 18661093
    [Abstract] [Full Text] [Related]

  • 17. Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS).
    Chang SC, Thibodeaux JR, Eastvold ML, Ehresman DJ, Bjork JA, Froehlich JW, Lau C, Singh RJ, Wallace KB, Butenhoff JL.
    Toxicology; 2008 Jan 20; 243(3):330-9. PubMed ID: 18063289
    [Abstract] [Full Text] [Related]

  • 18. Altered fatty acid homeostasis and related toxicologic sequelae in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS).
    Curran I, Hierlihy SL, Liston V, Pantazopoulos P, Nunnikhoven A, Tittlemier S, Barker M, Trick K, Bondy G.
    J Toxicol Environ Health A; 2008 Jan 20; 71(23):1526-41. PubMed ID: 18923995
    [Abstract] [Full Text] [Related]

  • 19. Perfluorooctane Sulfonate-Induced Hepatic Steatosis in Male Sprague Dawley Rats Is Not Attenuated by Dietary Choline Supplementation.
    Bagley BD, Chang SC, Ehresman DJ, Eveland A, Zitzow JD, Parker GA, Peters JM, Wallace KB, Butenhoff JL.
    Toxicol Sci; 2017 Dec 01; 160(2):284-298. PubMed ID: 28973659
    [Abstract] [Full Text] [Related]

  • 20. Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters.
    Luebker DJ, York RG, Hansen KJ, Moore JA, Butenhoff JL.
    Toxicology; 2005 Nov 05; 215(1-2):149-69. PubMed ID: 16129535
    [Abstract] [Full Text] [Related]

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