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223 related items for PubMed ID: 22252477

  • 1. Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: molecular insights and effector modulation of N-acetylglucosaminyltransferase I.
    Zhong X, Cooley C, Seth N, Juo ZS, Presman E, Resendes N, Kumar R, Allen M, Mosyak L, Stahl M, Somers W, Kriz R.
    Biotechnol Bioeng; 2012 Jul; 109(7):1723-34. PubMed ID: 22252477
    [Abstract] [Full Text] [Related]

  • 2. Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a point mutation in N-acetylglucosaminyltransferase I gene.
    Puthalakath H, Burke J, Gleeson PA.
    J Biol Chem; 1996 Nov 01; 271(44):27818-22. PubMed ID: 8910379
    [Abstract] [Full Text] [Related]

  • 3. Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII.
    Davies J, Jiang L, Pan LZ, LaBarre MJ, Anderson D, Reff M.
    Biotechnol Bioeng; 2001 Aug 20; 74(4):288-94. PubMed ID: 11410853
    [Abstract] [Full Text] [Related]

  • 4. Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II.
    Ferrara C, Brünker P, Suter T, Moser S, Püntener U, Umaña P.
    Biotechnol Bioeng; 2006 Apr 05; 93(5):851-61. PubMed ID: 16435400
    [Abstract] [Full Text] [Related]

  • 5. Five Lec1 CHO cell mutants have distinct Mgat1 gene mutations that encode truncated N-acetylglucosaminyltransferase I.
    Chen W, Stanley P.
    Glycobiology; 2003 Jan 05; 13(1):43-50. PubMed ID: 12634323
    [Abstract] [Full Text] [Related]

  • 6. N-Glycosylation engineering of lepidopteran insect cells by the introduction of the beta1,4-N-acetylglucosaminyltransferase III gene.
    Okada T, Ihara H, Ito R, Nakano M, Matsumoto K, Yamaguchi Y, Taniguchi N, Ikeda Y.
    Glycobiology; 2010 Sep 05; 20(9):1147-59. PubMed ID: 20554946
    [Abstract] [Full Text] [Related]

  • 7. Independent Lec1A CHO glycosylation mutants arise from point mutations in N-acetylglucosaminyltransferase I that reduce affinity for both substrates. Molecular consequences based on the crystal structure of GlcNAc-TI.
    Chen W, Unligil UM, Rini JM, Stanley P.
    Biochemistry; 2001 Jul 31; 40(30):8765-72. PubMed ID: 11467936
    [Abstract] [Full Text] [Related]

  • 8. Molecular analysis of three gain-of-function CHO mutants that add the bisecting GlcNAc to N-glycans.
    Stanley P, Sundaram S, Tang J, Shi S.
    Glycobiology; 2005 Jan 31; 15(1):43-53. PubMed ID: 15329358
    [Abstract] [Full Text] [Related]

  • 9. The interplay of protein engineering and glycoengineering to fine-tune antibody glycosylation and its impact on effector functions.
    Wang Q, Wang T, Zhang R, Yang S, McFarland KS, Chung CY, Jia H, Wang LX, Cipollo JF, Betenbaugh MJ.
    Biotechnol Bioeng; 2022 Jan 31; 119(1):102-117. PubMed ID: 34647616
    [Abstract] [Full Text] [Related]

  • 10. An Arabidopsis thaliana cDNA complements the N-acetylglucosaminyltransferase I deficiency of CHO Lec1 cells.
    Bakker H, Lommen A, Jordi W, Stiekema W, Bosch D.
    Biochem Biophys Res Commun; 1999 Aug 11; 261(3):829-32. PubMed ID: 10441510
    [Abstract] [Full Text] [Related]

  • 11. Engineering Chinese hamster ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)-mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1).
    Sealover NR, Davis AM, Brooks JK, George HJ, Kayser KJ, Lin N.
    J Biotechnol; 2013 Aug 10; 167(1):24-32. PubMed ID: 23777858
    [Abstract] [Full Text] [Related]

  • 12. Effect of C2-associated carbohydrate structure on Ig effector function: studies with chimeric mouse-human IgG1 antibodies in glycosylation mutants of Chinese hamster ovary cells.
    Wright A, Morrison SL.
    J Immunol; 1998 Apr 01; 160(7):3393-402. PubMed ID: 9531299
    [Abstract] [Full Text] [Related]

  • 13. Identification of functional elements of the GDP-fucose transporter SLC35C1 using a novel Chinese hamster ovary mutant.
    Zhang P, Haryadi R, Chan KF, Teo G, Goh J, Pereira NA, Feng H, Song Z.
    Glycobiology; 2012 Jul 01; 22(7):897-911. PubMed ID: 22492235
    [Abstract] [Full Text] [Related]

  • 14. Control of recombinant monoclonal antibody effector functions by Fc N-glycan remodeling in vitro.
    Hodoniczky J, Zheng YZ, James DC.
    Biotechnol Prog; 2005 Jul 01; 21(6):1644-52. PubMed ID: 16321047
    [Abstract] [Full Text] [Related]

  • 15. Structure, biosynthesis, and function of the hexose transporter in Chinese hamster ovary cells deficient in N-acetylglucosaminyltransferase 1 activity.
    Haspel HC, Revillame J, Rosen OM.
    J Cell Physiol; 1988 Aug 01; 136(2):361-6. PubMed ID: 2970467
    [Abstract] [Full Text] [Related]

  • 16. Removal of 106 amino acids from the N-terminus of UDP-GlcNAc: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I does not inactivate the enzyme.
    Sarkar M, Pagny S, Unligil U, Joziasse D, Mucha J, Glössl J, Schachter H.
    Glycoconj J; 1998 Feb 01; 15(2):193-7. PubMed ID: 9557881
    [Abstract] [Full Text] [Related]

  • 17. An N-acetylglucosaminyltransferase of the Golgi apparatus of the yeast Saccharomyces cerevisiae that can modify N-linked glycans.
    Yoko-o T, Wiggins CA, Stolz J, Peak-Chew SY, Munro S.
    Glycobiology; 2003 Aug 01; 13(8):581-9. PubMed ID: 12651885
    [Abstract] [Full Text] [Related]

  • 18. Anti-pig antibody adsorption efficacy of {alpha}-Gal carrying recombinant P-selectin glycoprotein ligand-1/immunoglobulin chimeras increases with core 2 {beta}1, 6-N-acetylglucosaminyltransferase expression.
    Liu J, Gustafsson A, Breimer ME, Kussak A, Holgersson J.
    Glycobiology; 2005 Jun 01; 15(6):571-83. PubMed ID: 15625182
    [Abstract] [Full Text] [Related]

  • 19. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.
    Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G.
    Mol Pharmacol; 2005 Mar 01; 67(3):868-76. PubMed ID: 15576633
    [Abstract] [Full Text] [Related]

  • 20. Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types.
    Kanda Y, Yamada T, Mori K, Okazaki A, Inoue M, Kitajima-Miyama K, Kuni-Kamochi R, Nakano R, Yano K, Kakita S, Shitara K, Satoh M.
    Glycobiology; 2007 Jan 01; 17(1):104-18. PubMed ID: 17012310
    [Abstract] [Full Text] [Related]

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