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Journal Abstract Search

250 related items for PubMed ID: 22253692

  • 1. Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
    Stockwell SR, Platt G, Barrie SE, Zoumpoulidou G, Te Poele RH, Aherne GW, Wilson SC, Sheldrake P, McDonald E, Venet M, Soudy C, Elustondo F, Rigoreau L, Blagg J, Workman P, Garrett MD, Mittnacht S.
    PLoS One; 2012; 7(1):e28568. PubMed ID: 22253692
    [Abstract] [Full Text] [Related]

  • 2. PERK activation by CCT020312 chemosensitizes colorectal cancer through inducing apoptosis regulated by ER stress.
    Lei Y, He L, Yan C, Wang Y, Lv G.
    Biochem Biophys Res Commun; 2021 Jun 11; 557():316-322. PubMed ID: 33894420
    [Abstract] [Full Text] [Related]

  • 3. A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models.
    Ganz J, Shacham T, Kramer M, Shenkman M, Eiger H, Weinberg N, Iancovici O, Roy S, Simhaev L, Da'adoosh B, Engel H, Perets N, Barhum Y, Portnoy M, Offen D, Lederkremer GZ.
    Sci Rep; 2020 Apr 23; 10(1):6875. PubMed ID: 32327686
    [Abstract] [Full Text] [Related]

  • 4. PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.
    Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA.
    Mol Biol Cell; 2005 Dec 23; 16(12):5493-501. PubMed ID: 16176978
    [Abstract] [Full Text] [Related]

  • 5. Astragaloside IV ameliorated neuroinflammation and improved neurological functions in mice exposed to traumatic brain injury by modulating the PERK-eIF2α-ATF4 signaling pathway.
    Zhao J, Zhao G, Lang J, Sun B, Feng S, Li D, Sun G.
    J Investig Med; 2024 Oct 23; 72(7):747-762. PubMed ID: 38869170
    [Abstract] [Full Text] [Related]

  • 6. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
    Yang H, Wen Y, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Ye T, Bai X, Xiao G, Wang M.
    Autophagy; 2020 Feb 23; 16(2):271-288. PubMed ID: 31007149
    [Abstract] [Full Text] [Related]

  • 7. Chrysin induces death of prostate cancer cells by inducing ROS and ER stress.
    Ryu S, Lim W, Bazer FW, Song G.
    J Cell Physiol; 2017 Dec 23; 232(12):3786-3797. PubMed ID: 28213961
    [Abstract] [Full Text] [Related]

  • 8. PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation.
    Raven JF, Baltzis D, Wang S, Mounir Z, Papadakis AI, Gao HQ, Koromilas AE.
    J Biol Chem; 2008 Feb 08; 283(6):3097-3108. PubMed ID: 18063576
    [Abstract] [Full Text] [Related]

  • 9. Dual activators of protein kinase R (PKR) and protein kinase R-like kinase PERK identify common and divergent catalytic targets.
    Bai H, Chen T, Ming J, Sun H, Cao P, Fusco DN, Chung RT, Chorev M, Jin Q, Aktas BH.
    Chembiochem; 2013 Jul 08; 14(10):1255-62. PubMed ID: 23784735
    [Abstract] [Full Text] [Related]

  • 10. CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis.
    Li X, Yu X, Zhou D, Chen B, Li W, Zheng X, Zeng H, Long L, Zhou W.
    Front Pharmacol; 2020 Jul 08; 11():737. PubMed ID: 32508655
    [Abstract] [Full Text] [Related]

  • 11. Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation.
    Xie W, Pariollaud M, Wixted WE, Chitnis N, Fornwald J, Truong M, Pao C, Liu Y, Ames RS, Callahan J, Solari R, Sanchez Y, Diehl A, Li H.
    PLoS One; 2015 Jul 08; 10(3):e0119738. PubMed ID: 25780921
    [Abstract] [Full Text] [Related]

  • 12. Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival.
    Alasiri G, Jiramongkol Y, Trakansuebkul S, Ke HL, Mahmud Z, Intuyod K, Lam EW.
    Mol Cell Endocrinol; 2020 Sep 15; 515():110932. PubMed ID: 32615282
    [Abstract] [Full Text] [Related]

  • 13. PERK signalling pathway mediates single prolonged stress-induced dysfunction of medial prefrontal cortex neurons.
    Wen L, Xiao B, Shi Y, Han F.
    Apoptosis; 2017 Jun 15; 22(6):753-768. PubMed ID: 28391375
    [Abstract] [Full Text] [Related]

  • 14. PERK mediates cell-cycle exit during the mammalian unfolded protein response.
    Brewer JW, Diehl JA.
    Proc Natl Acad Sci U S A; 2000 Nov 07; 97(23):12625-30. PubMed ID: 11035797
    [Abstract] [Full Text] [Related]

  • 15. PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK-TBL2-eIF2ɑ-ATF4 pathway.
    Zhou X, Xiong H, Lu Y, Geng M, Lu Y, Zhang L, Zhu X.
    Biochem Biophys Res Commun; 2021 Jul 05; 561():73-79. PubMed ID: 34015761
    [Abstract] [Full Text] [Related]

  • 16. CCT020312 exerts anti-prostate cancer effect by inducing G1 cell cycle arrest, apoptosis and autophagy through activation of PERK/eIF2α/ATF4/CHOP signaling.
    Zhou D, Yin M, Kang B, Yu X, Zeng H, Chen B, Wang G, Song Y, Liu X, He Q, Wu Q, Zhang L, Wu L, Wu Y, Qu N, Li X, Zhou W.
    Biochem Pharmacol; 2024 Mar 05; 221():116038. PubMed ID: 38286211
    [Abstract] [Full Text] [Related]

  • 17. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses.
    Guthrie LN, Abiraman K, Plyler ES, Sprenkle NT, Gibson SA, McFarland BC, Rajbhandari R, Rowse AL, Benveniste EN, Meares GP.
    J Biol Chem; 2016 Jul 22; 291(30):15830-40. PubMed ID: 27226638
    [Abstract] [Full Text] [Related]

  • 18. Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications.
    Krishnamoorthy J, Rajesh K, Mirzajani F, Kesoglidou P, Papadakis AI, Koromilas AE.
    Cell Cycle; 2014 Jul 22; 13(5):801-6. PubMed ID: 24401334
    [Abstract] [Full Text] [Related]

  • 19. Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stress.
    Ghura S, Beratan NR, Shi X, Alvarez-Periel E, Bond Newton SE, Akay-Espinoza C, Jordan-Sciutto KL.
    Sci Rep; 2024 Oct 11; 14(1):23812. PubMed ID: 39394239
    [Abstract] [Full Text] [Related]

  • 20. β-Elemonic acid inhibits the growth of human Osteosarcoma through endoplasmic reticulum (ER) stress-mediated PERK/eIF2α/ATF4/CHOP activation and Wnt/β-catenin signal suppression.
    Zhao A, Zhang Z, Zhou Y, Li X, Li X, Ma B, Zhang Q.
    Phytomedicine; 2020 Apr 11; 69():153183. PubMed ID: 32113150
    [Abstract] [Full Text] [Related]

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