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Journal Abstract Search

95 related items for PubMed ID: 22264488

  • 1. Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
    Shen HC, Ding FX, Jiang J, Verras A, Chabin RM, Xu S, Tong X, Chen Q, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Murphy BA, Gorski JN, Wiltsie J, SinhaRoy R, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1550-6. PubMed ID: 22264488
    [Abstract] [Full Text] [Related]

  • 2. Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
    Shen HC, Ding FX, Zhou C, Xiong Y, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen D, Sinharoy R, Hale JJ, Tata JR, Pinto S, Shen DM, Colletti SL.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1299-305. PubMed ID: 21315588
    [Abstract] [Full Text] [Related]

  • 3. Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.
    Wu Z, Yang C, Graham TH, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Shen Z, Chen Q, Bleasby K, Sinharoy R, Hale JJ, Tata JR, Pinto S, Colletti SL, Shen DM.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1727-30. PubMed ID: 22290078
    [Abstract] [Full Text] [Related]

  • 4. Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
    Wu Z, Yang C, Xiong Y, Feng Z, Lombardo M, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen Q, Sinharoy R, Hale JJ, Tata JR, Pinto S, Shen DM, Colletti SL.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1774-8. PubMed ID: 22248857
    [Abstract] [Full Text] [Related]

  • 5. A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
    Graham TH, Liu W, Verras A, Sebhat IK, Xiong Y, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, Tong X, Tung EC, Wiltsie J, Xiao J, Xie D, Xu S, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2811-7. PubMed ID: 22444683
    [Abstract] [Full Text] [Related]

  • 6. Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
    Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Li X, Lisnock J, Shen Z, Tong X, Tung EC, Wiltsie J, Xu S, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2013 Dec 01; 23(23):6228-33. PubMed ID: 24157366
    [Abstract] [Full Text] [Related]

  • 7. A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
    Graham TH, Liu W, Verras A, Reibarkh M, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, Tong X, Tung EC, Wiltsie J, Xie D, Xu S, Xiao J, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2818-22. PubMed ID: 22444685
    [Abstract] [Full Text] [Related]

  • 8. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
    Graham TH, Shen HC, Liu W, Xiong Y, Verras A, Bleasby K, Bhatt UR, Chabin RM, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Lassman ME, Shen Z, Tong X, Tung EC, Xie D, Xu S, Colletti SL, Tata JR, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):658-65. PubMed ID: 22079761
    [Abstract] [Full Text] [Related]

  • 9. Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
    Zhou C, Garcia-Calvo M, Pinto S, Lombardo M, Feng Z, Bender K, Pryor KD, Bhatt UR, Chabin RM, Geissler WM, Shen Z, Tong X, Zhang Z, Wong KK, Roy RS, Chapman KT, Yang L, Xiong Y.
    J Med Chem; 2010 Oct 14; 53(19):7251-63. PubMed ID: 20857914
    [Abstract] [Full Text] [Related]

  • 10. Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors.
    Graham TH, Shu M, Verras A, Chen Q, Garcia-Calvo M, Li X, Lisnock J, Tong X, Tung EC, Wiltsie J, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2014 Apr 01; 24(7):1657-60. PubMed ID: 24636945
    [Abstract] [Full Text] [Related]

  • 11. Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.
    Graham TH.
    Expert Opin Ther Pat; 2017 Oct 01; 27(10):1077-1088. PubMed ID: 28699813
    [Abstract] [Full Text] [Related]

  • 12. Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.
    Yun W, Ahmad M, Chen Y, Gillespie P, Conde-Knape K, Kazmer S, Li S, Qian Y, Taub R, Wertheimer SJ, Whittard T, Bolin D.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7205-9. PubMed ID: 22001092
    [Abstract] [Full Text] [Related]

  • 13. Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
    Hornberger KR, Chen X, Crew AP, Kleinberg A, Ma L, Mulvihill MJ, Wang J, Wilde VL, Albertella M, Bittner M, Cooke A, Kadhim S, Kahler J, Maresca P, May E, Meyn P, Romashko D, Tokar B, Turton R.
    Bioorg Med Chem Lett; 2013 Aug 15; 23(16):4511-6. PubMed ID: 23856049
    [Abstract] [Full Text] [Related]

  • 14. Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
    Hornberger KR, Berger DM, Crew AP, Dong H, Kleinberg A, Li AH, Medeiros MR, Mulvihill MJ, Siu K, Tarrant J, Wang J, Weng F, Wilde VL, Albertella M, Bittner M, Cooke A, Gray MJ, Maresca P, May E, Meyn P, Peick W, Romashko D, Tanowitz M, Tokar B.
    Bioorg Med Chem Lett; 2013 Aug 15; 23(16):4517-22. PubMed ID: 23850198
    [Abstract] [Full Text] [Related]

  • 15. Discovery of novel SCD1 inhibitors: 5-alkyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] analogs.
    Uto Y, Ueno Y, Kiyotsuka Y, Miyazawa Y, Kurata H, Ogata T, Takagi T, Wakimoto S, Ohsumi J.
    Eur J Med Chem; 2011 May 15; 46(5):1892-6. PubMed ID: 21356569
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis and biological evaluation of noncovalent inhibitors of human CD38 NADase.
    Zhou Y, Ting KY, Lam CM, Kwong AK, Xia J, Jin H, Liu Z, Zhang L, Cheung Lee H, Zhang L.
    ChemMedChem; 2012 Feb 06; 7(2):223-8. PubMed ID: 22287152
    [No Abstract] [Full Text] [Related]

  • 17. PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
    Wrobel J, Sredy J, Moxham C, Dietrich A, Li Z, Sawicki DR, Seestaller L, Wu L, Katz A, Sullivan D, Tio C, Zhang ZY.
    J Med Chem; 1999 Aug 26; 42(17):3199-202. PubMed ID: 10464006
    [No Abstract] [Full Text] [Related]

  • 18. Synthesis and biological activity of novel MIF antagonists.
    Balachandran S, Gadekar PK, Parkale S, Yadav VN, Kamath D, Ramaswamy S, Sharma S, Vishwakarma RA, Dagia NM.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1508-11. PubMed ID: 21277206
    [Abstract] [Full Text] [Related]

  • 19. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.
    Takle AK, Bamford MJ, Davies S, Davis RP, Dean DK, Gaiba A, Irving EA, King FD, Naylor A, Parr CA, Ray AM, Reith AD, Smith BB, Staton PC, Steadman JG, Stean TO, Wilson DM.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4373-6. PubMed ID: 18621524
    [Abstract] [Full Text] [Related]

  • 20. Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors.
    Kinoshita K, Ono Y, Emura T, Asoh K, Furuichi N, Ito T, Kawada H, Tanaka S, Morikami K, Tsukaguchi T, Sakamoto H, Tsukuda T, Oikawa N.
    Bioorg Med Chem Lett; 2011 Jun 15; 21(12):3788-93. PubMed ID: 21561771
    [Abstract] [Full Text] [Related]

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