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Journal Abstract Search

171 related items for PubMed ID: 22278967

  • 21. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.
    Ramírez de Molina A, Báñez-Coronel M, Gutiérrez R, Rodríguez-González A, Olmeda D, Megías D, Lacal JC.
    Cancer Res; 2004 Sep 15; 64(18):6732-9. PubMed ID: 15374991
    [Abstract] [Full Text] [Related]

  • 22. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.
    Rodríguez-González A, Ramirez de Molina A, Fernández F, Lacal JC.
    Oncogene; 2004 Oct 28; 23(50):8247-59. PubMed ID: 15378008
    [Abstract] [Full Text] [Related]

  • 23. Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.
    Ramírez de Molina A, Rodríguez-González A, Penalva V, Lucas L, Lacal JC.
    Biochem Biophys Res Commun; 2001 Jul 27; 285(4):873-9. PubMed ID: 11467831
    [Abstract] [Full Text] [Related]

  • 24. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA, Spicer JA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA.
    J Med Chem; 1999 Jul 01; 42(13):2383-93. PubMed ID: 10395479
    [Abstract] [Full Text] [Related]

  • 25. QSAR-derived choline kinase inhibitors: how rational can antiproliferative drug design be?
    Campos J, Núñez MC, Conejo-García A, Sánchez-Martín RM, Hernández-Alcoceba R, Rodríguez-González A, Lacal JC, Gallo MA, Espinosa A.
    Curr Med Chem; 2003 Jul 01; 10(13):1095-112. PubMed ID: 12678804
    [Abstract] [Full Text] [Related]

  • 26. A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products.
    Estévez-Braun A, Ravelo AG, Pérez-Sacau E, Lacal JC.
    Clin Transl Oncol; 2015 Jan 01; 17(1):74-84. PubMed ID: 25472447
    [Abstract] [Full Text] [Related]

  • 27. In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery.
    Hernández-Alcoceba R, Fernández F, Lacal JC.
    Cancer Res; 1999 Jul 01; 59(13):3112-8. PubMed ID: 10397253
    [Abstract] [Full Text] [Related]

  • 28. Antiproliferative and protein kinase binding activities of Some N6, 5'-bis-ureido 5'-amino-5'-deoxyadenosine derivatives.
    Peterson MA, Oliveira M, Christiansen MA.
    Nucleosides Nucleotides Nucleic Acids; 2009 May 01; 28(5):394-407. PubMed ID: 20183591
    [Abstract] [Full Text] [Related]

  • 29. QSAR of 1,1'-(1,2-ethylenebisbenzyl)bis(4-substitutedpyridinium) dibromides as choline kinase inhibitors: a different approach for antiproliferative drug design.
    Campos J, Núñez MC, Rodríguez V, Gallo MA, Espinosa A.
    Bioorg Med Chem Lett; 2000 Apr 17; 10(8):767-70. PubMed ID: 10782682
    [Abstract] [Full Text] [Related]

  • 30. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.
    Ramírez de Molina A, Gutiérrez R, Ramos MA, Silva JM, Silva J, Bonilla F, Sánchez JJ, Lacal JC.
    Oncogene; 2002 Jun 20; 21(27):4317-22. PubMed ID: 12082619
    [Abstract] [Full Text] [Related]

  • 31. Synthesis and antiproliferative activity of unsaturated quinoline derivatives.
    Montgomery GJ, McKeown P, McGown AT, Robins DJ.
    Anticancer Drug Des; 2000 Jun 20; 15(3):171-81. PubMed ID: 11049085
    [Abstract] [Full Text] [Related]

  • 32. Directing novel ChoKα1 inhibitors using MamC-mediated biomimetic magnetic nanoparticles: a way to improve specificity and efficiency.
    Sola-Leyva A, Jabalera Y, Jimenez-Carretero M, Lázaro M, Pozo-Gualda T, García-Vargas PJ, Luque-Navarro PM, Fasiolo A, López-Cara LC, Iglesias GR, Paz Carrasco-Jiménez M, Jiménez-López C.
    Bioorg Chem; 2024 Oct 20; 151():107693. PubMed ID: 39116523
    [Abstract] [Full Text] [Related]

  • 33. Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
    Hong BS, Allali-Hassani A, Tempel W, Finerty PJ, Mackenzie F, Dimov S, Vedadi M, Park HW.
    J Biol Chem; 2010 May 21; 285(21):16330-40. PubMed ID: 20299452
    [Abstract] [Full Text] [Related]

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  • 35. Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
    Zech SG, Kohlmann A, Zhou T, Li F, Squillace RM, Parillon LE, Greenfield MT, Miller DP, Qi J, Thomas RM, Wang Y, Xu Y, Miret JJ, Shakespeare WC, Zhu X, Dalgarno DC.
    J Med Chem; 2016 Jan 28; 59(2):671-86. PubMed ID: 26700752
    [Abstract] [Full Text] [Related]

  • 36. Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells.
    Lacal JC, Campos JM.
    Mol Cancer Ther; 2015 Jan 28; 14(1):31-9. PubMed ID: 25487918
    [Abstract] [Full Text] [Related]

  • 37. Synthesis and antitumor activity of novel benzimidazole-5-carboxylic acid derivatives and their transition metal complexes as topoisomerease II inhibitors.
    Galal SA, Hegab KH, Hashem AM, Youssef NS.
    Eur J Med Chem; 2010 Dec 28; 45(12):5685-91. PubMed ID: 20884089
    [Abstract] [Full Text] [Related]

  • 38. Anticancer activities of novel chalcone and bis-chalcone derivatives.
    Modzelewska A, Pettit C, Achanta G, Davidson NE, Huang P, Khan SR.
    Bioorg Med Chem; 2006 May 15; 14(10):3491-5. PubMed ID: 16434201
    [Abstract] [Full Text] [Related]

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  • 40. Synthesis, characterization and cytotoxicity of some novel 1,3-disubstituted-2,3-dihydro-2-iminobenzimidazoles.
    Mavrova ATs, Wesselinova D, Vassilev N, Tsenov JA.
    Eur J Med Chem; 2011 Aug 15; 46(8):3362-7. PubMed ID: 21605925
    [Abstract] [Full Text] [Related]

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