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Journal Abstract Search

141 related items for PubMed ID: 22290078

  • 21. Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
    Hornberger KR, Chen X, Crew AP, Kleinberg A, Ma L, Mulvihill MJ, Wang J, Wilde VL, Albertella M, Bittner M, Cooke A, Kadhim S, Kahler J, Maresca P, May E, Meyn P, Romashko D, Tokar B, Turton R.
    Bioorg Med Chem Lett; 2013 Aug 15; 23(16):4511-6. PubMed ID: 23856049
    [Abstract] [Full Text] [Related]

  • 22. Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.
    Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1434-7. PubMed ID: 21310612
    [Abstract] [Full Text] [Related]

  • 23. Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
    Hornberger KR, Berger DM, Crew AP, Dong H, Kleinberg A, Li AH, Medeiros MR, Mulvihill MJ, Siu K, Tarrant J, Wang J, Weng F, Wilde VL, Albertella M, Bittner M, Cooke A, Gray MJ, Maresca P, May E, Meyn P, Peick W, Romashko D, Tanowitz M, Tokar B.
    Bioorg Med Chem Lett; 2013 Aug 15; 23(16):4517-22. PubMed ID: 23850198
    [Abstract] [Full Text] [Related]

  • 24. Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
    Rewcastle GW, Palmer BD, Bridges AJ, Showalter HD, Sun L, Nelson J, McMichael A, Kraker AJ, Fry DW, Denny WA.
    J Med Chem; 1996 Feb 16; 39(4):918-28. PubMed ID: 8632415
    [Abstract] [Full Text] [Related]

  • 25. Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3.
    Tully DC, Liu H, Alper PB, Chatterjee AK, Epple R, Roberts MJ, Williams JA, Nguyen KT, Woodmansee DH, Tumanut C, Li J, Spraggon G, Chang J, Tuntland T, Harris JL, Karanewsky DS.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1975-80. PubMed ID: 16446091
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  • 26. Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping.
    Chen Q, Tian W, Han G, Qi J, Zheng C, Zhou Y, Ding L, Zhao J, Zhu J, Lv J, Sheng C.
    Eur J Med Chem; 2013 Jan 01; 59():176-82. PubMed ID: 23220646
    [Abstract] [Full Text] [Related]

  • 27. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Roche D, Carniato D, Leriche C, Lepifre F, Christmann-Franck S, Graedler U, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2674-8. PubMed ID: 19395260
    [Abstract] [Full Text] [Related]

  • 28. A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
    Lewis SJ, Smith AL, Neduvelil JG, Stevenson GI, Lindon MJ, Jones AB, Shearman MS, Beher D, Clarke E, Best JD, Peachey JE, Harrison T, Castro JL.
    Bioorg Med Chem Lett; 2005 Jan 17; 15(2):373-8. PubMed ID: 15603957
    [Abstract] [Full Text] [Related]

  • 29. Discovery of a series of aminopiperidines as novel iNOS inhibitors.
    Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE.
    Bioorg Med Chem Lett; 2008 Jan 01; 18(1):336-43. PubMed ID: 18024030
    [Abstract] [Full Text] [Related]

  • 30. A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.
    Shen HC, Ding FX, Deng Q, Xu S, Tong X, Zhang X, Chen Y, Zhou G, Pai LY, Alonso-Galicia M, Roy S, Zhang B, Tata JR, Berger JP, Colletti SL.
    Bioorg Med Chem Lett; 2009 Oct 01; 19(19):5716-21. PubMed ID: 19700315
    [Abstract] [Full Text] [Related]

  • 31. Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.
    Wang Y, Yang W, Finlay HJ, Harikrishnan LS, Jiang J, Kamau MG, Van Kirk K, Nirschl DS, Taylor DS, Chen AY, Yin X, Sleph PG, Yang RZ, Huang CS, Adam LP, Lawrence RM, Wexler RR, Salvati ME.
    Bioorg Med Chem Lett; 2014 Feb 01; 24(3):860-4. PubMed ID: 24424134
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  • 32. Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors.
    Wilson KJ, Illig CR, Chen J, Wall MJ, Ballentine SK, DesJarlais RL, Chen Y, Schubert C, Donatelli R, Petrounia I, Crysler CS, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Meegalla SK.
    Bioorg Med Chem Lett; 2010 Jul 01; 20(13):3925-9. PubMed ID: 20570147
    [Abstract] [Full Text] [Related]

  • 33. Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors.
    Su X, Pradaux-Caggiano F, Thomas MP, Szeto MW, Halem HA, Culler MD, Vicker N, Potter BV.
    ChemMedChem; 2010 Jul 05; 5(7):1026-44. PubMed ID: 20486152
    [Abstract] [Full Text] [Related]

  • 34. MMP-13 selective α-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres.
    Barta TE, Becker DP, Bedell LJ, Easton AM, Hockerman SL, Kiefer J, Munie GE, Mathis KJ, Li MH, Rico JG, Villamil CI, Williams JM.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):2820-2. PubMed ID: 21507637
    [Abstract] [Full Text] [Related]

  • 35. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.
    Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1438-41. PubMed ID: 21310609
    [Abstract] [Full Text] [Related]

  • 36. Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.
    Stachel SJ, Coburn CA, Rush D, Jones KL, Zhu H, Rajapakse H, Graham SL, Simon A, Katharine Holloway M, Allison TJ, Munshi SK, Espeseth AS, Zuck P, Colussi D, Wolfe A, Pietrak BL, Lai MT, Vacca JP.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):2977-80. PubMed ID: 19409780
    [Abstract] [Full Text] [Related]

  • 37. Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
    Sutton JM, Clark DE, Dunsdon SJ, Fenton G, Fillmore A, Harris NV, Higgs C, Hurley CA, Krintel SL, MacKenzie RE, Duttaroy A, Gangl E, Maniara W, Sedrani R, Namoto K, Ostermann N, Gerhartz B, Sirockin F, Trappe J, Hassiepen U, Baeschlin DK.
    Bioorg Med Chem Lett; 2012 Feb 01; 22(3):1464-8. PubMed ID: 22177783
    [Abstract] [Full Text] [Related]

  • 38. Heterocyclic core analogs of a direct thrombin inhibitor.
    Blizzard TA, Singh S, Patil B, Chidurala N, Komanduri V, Debnath S, Belyakov S, Crespo A, Struck A, Kurtz M, Wiltsie J, Shen X, Sonatore L, Arocho M, Lewis D, Ogletree M, Biftu T.
    Bioorg Med Chem Lett; 2014 Feb 15; 24(4):1111-5. PubMed ID: 24461292
    [Abstract] [Full Text] [Related]

  • 39. The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase.
    Bilodeau MT, Rodman LD, McGaughey GB, Coll KE, Koester TJ, Hoffman WF, Hungate RW, Kendall RL, McFall RC, Rickert KW, Rutledge RZ, Thomas KA.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2941-5. PubMed ID: 15125964
    [Abstract] [Full Text] [Related]

  • 40. N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.
    Wu L, Lu K, Desai M, Packiarajan M, Joshi A, Marzabadi MR, Jubian V, Andersen K, Chandrasena G, Boyle NJ, Walker MW.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5573-6. PubMed ID: 21782430
    [Abstract] [Full Text] [Related]

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