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181 related items for PubMed ID: 22294377

  • 1. Measuring receptor target coverage: a radioligand competition binding protocol for assessing the association and dissociation rates of unlabeled compounds.
    Sykes DA, Dowling MR, Charlton SJ.
    Curr Protoc Pharmacol; 2010 Sep; Chapter 9():Unit 9.14. PubMed ID: 22294377
    [Abstract] [Full Text] [Related]

  • 2. Dual-point competition association assay: a fast and high-throughput kinetic screening method for assessing ligand-receptor binding kinetics.
    Guo D, van Dorp EJ, Mulder-Krieger T, van Veldhoven JP, Brussee J, Ijzerman AP, Heitman LH.
    J Biomol Screen; 2013 Mar; 18(3):309-20. PubMed ID: 23093571
    [Abstract] [Full Text] [Related]

  • 3. Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.
    Packeu A, Wennerberg M, Balendran A, Vauquelin G.
    Br J Pharmacol; 2010 Nov; 161(6):1311-28. PubMed ID: 20946109
    [Abstract] [Full Text] [Related]

  • 4. Use of scintillation proximity assay to measure radioligand binding to immobilized receptors without separation of bound from free ligand.
    Berry J, Price-Jones M, Killian B.
    Methods Mol Biol; 2012 Nov; 897():79-94. PubMed ID: 22674161
    [Abstract] [Full Text] [Related]

  • 5. Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.
    Malany S, Hernandez LM, Smith WF, Crowe PD, Hoare SR.
    J Recept Signal Transduct Res; 2009 Nov; 29(2):84-93. PubMed ID: 19308787
    [Abstract] [Full Text] [Related]

  • 6. Ligand dissociation constants from competition binding assays: errors associated with ligand depletion.
    Goldstein A, Barrett RW.
    Mol Pharmacol; 1987 Jun; 31(6):603-9. PubMed ID: 3600604
    [Abstract] [Full Text] [Related]

  • 7. Investigating the Influence of Tracer Kinetics on Competition-Kinetic Association Binding Assays: Identifying the Optimal Conditions for Assessing the Kinetics of Low-Affinity Compounds.
    Sykes DA, Jain P, Charlton SJ.
    Mol Pharmacol; 2019 Sep; 96(3):378-392. PubMed ID: 31436538
    [Abstract] [Full Text] [Related]

  • 8. Radioligand binding assays and their analysis.
    Maguire JJ, Kuc RE, Davenport AP.
    Methods Mol Biol; 2012 Sep; 897():31-77. PubMed ID: 22674160
    [Abstract] [Full Text] [Related]

  • 9. Ligand binding assays at equilibrium: validation and interpretation.
    Hulme EC, Trevethick MA.
    Br J Pharmacol; 2010 Nov; 161(6):1219-37. PubMed ID: 20132208
    [Abstract] [Full Text] [Related]

  • 10. A new, simple and robust radioligand binding method used to determine kinetic off-rate constants for unlabeled ligands. Application at α2A- and α2C-adrenoceptors.
    Uhlén S, Schiöth HB, Jahnsen JA.
    Eur J Pharmacol; 2016 Oct 05; 788():113-121. PubMed ID: 27318322
    [Abstract] [Full Text] [Related]

  • 11. Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.
    Sullivan SK, Hoare SR, Fleck BA, Zhu YF, Heise CE, Struthers RS, Crowe PD.
    Biochem Pharmacol; 2006 Sep 28; 72(7):838-49. PubMed ID: 16930559
    [Abstract] [Full Text] [Related]

  • 12. Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach.
    Shimizu Y, Ogawa K, Nakayama M.
    J Biomol Screen; 2016 Aug 28; 21(7):729-37. PubMed ID: 27270099
    [Abstract] [Full Text] [Related]

  • 13. A simple method for calculating the dissociation constant of a receptor (or enzyme).unlabeled ligand complex from radioligand displacement measurements.
    Martin RL, Renosto F, Segel IH.
    Arch Biochem Biophys; 1991 Jan 28; 284(1):26-9. PubMed ID: 1989501
    [Abstract] [Full Text] [Related]

  • 14. Scintillation proximity assay (SPA) as a new approach to determine a ligand's kinetic profile. A case in point for the adenosine A1 receptor.
    Xia L, de Vries H, IJzerman AP, Heitman LH.
    Purinergic Signal; 2016 Mar 28; 12(1):115-26. PubMed ID: 26647040
    [Abstract] [Full Text] [Related]

  • 15. Practical aspects of radioligand binding.
    McKinney M, Raddatz R.
    Curr Protoc Pharmacol; 2006 Jul 28; Chapter 1():Unit1.3. PubMed ID: 22294165
    [Abstract] [Full Text] [Related]

  • 16. SIMUL: an accurate method for the determination of receptor subtype proportions using a personal computer.
    Williams DW, Summers RJ.
    Comput Methods Programs Biomed; 1990 Jun 28; 32(2):137-9. PubMed ID: 2397637
    [Abstract] [Full Text] [Related]

  • 17. Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions?
    Wittmann HJ, Strasser A.
    Naunyn Schmiedebergs Arch Pharmacol; 2017 Jun 28; 390(6):595-612. PubMed ID: 28220211
    [Abstract] [Full Text] [Related]

  • 18. In vitro muscarinic receptor radioligand-binding assays.
    Steinfeld T, Pulido-Rios MT, Armstrong S, Hegde SS.
    Curr Protoc Pharmacol; 2010 Mar 28; Chapter 1():Unit 1.33. PubMed ID: 22294363
    [Abstract] [Full Text] [Related]

  • 19. Characterization of two novel tritiated radioligands for labelling Neuropeptide FF (NPFF(1) and NPFF(2)) receptors.
    Talmont F, Garcia LP, Mazarguil H, Zajac JM, Mollereau C.
    Neurochem Int; 2009 Dec 28; 55(8):815-9. PubMed ID: 19682524
    [Abstract] [Full Text] [Related]

  • 20. GPCR-radioligand binding assays.
    Flanagan CA.
    Methods Cell Biol; 2016 Dec 28; 132():191-215. PubMed ID: 26928545
    [Abstract] [Full Text] [Related]

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