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Journal Abstract Search

166 related items for PubMed ID: 22296642

  • 1. Identification and characterization of reactive metabolites in natural products-driven drug discovery.
    Njuguna NM, Masimirembwa C, Chibale K.
    J Nat Prod; 2012 Mar 23; 75(3):507-13. PubMed ID: 22296642
    [Abstract] [Full Text] [Related]

  • 2. Structural alerts, reactive metabolites, and protein covalent binding: how reliable are these attributes as predictors of drug toxicity?
    Kalgutkar AS, Didiuk MT.
    Chem Biodivers; 2009 Nov 23; 6(11):2115-37. PubMed ID: 19937848
    [Abstract] [Full Text] [Related]

  • 3. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
    Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, Aleo MD.
    Chem Res Toxicol; 2011 Sep 19; 24(9):1345-410. PubMed ID: 21702456
    [Abstract] [Full Text] [Related]

  • 4. Natural products and Pharma 2011: strategic changes spur new opportunities.
    Carter GT.
    Nat Prod Rep; 2011 Oct 19; 28(11):1783-9. PubMed ID: 21909580
    [Abstract] [Full Text] [Related]

  • 5. Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.
    Park BK, Laverty H, Srivastava A, Antoine DJ, Naisbitt D, Williams DP.
    Chem Biol Interact; 2011 Jun 30; 192(1-2):30-6. PubMed ID: 20846520
    [Abstract] [Full Text] [Related]

  • 6. Strategies for dealing with reactive intermediates in drug discovery and development.
    Nassar AE, Lopez-Anaya A.
    Curr Opin Drug Discov Devel; 2004 Jan 30; 7(1):126-36. PubMed ID: 14982156
    [Abstract] [Full Text] [Related]

  • 7. Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates.
    Orhan H, Vermeulen NP.
    Curr Drug Metab; 2011 May 30; 12(4):383-94. PubMed ID: 21395525
    [Abstract] [Full Text] [Related]

  • 8. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
    Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA.
    Chem Res Toxicol; 2009 Feb 30; 22(2):357-68. PubMed ID: 19146377
    [Abstract] [Full Text] [Related]

  • 9. Characterization of cyanide-trapped methylated metabonates formed during reactive drug metabolite screening in vitro.
    Rousu T, Tolonen A.
    Rapid Commun Mass Spectrom; 2011 May 30; 25(10):1382-90. PubMed ID: 21504003
    [Abstract] [Full Text] [Related]

  • 10. Electrophilic natural products and their biological targets.
    Gersch M, Kreuzer J, Sieber SA.
    Nat Prod Rep; 2012 Jun 30; 29(6):659-82. PubMed ID: 22504336
    [Abstract] [Full Text] [Related]

  • 11. In vitro metabolic fate of a novel structural class: evidence for the formation of a reactive intermediate on a benzothiophene moiety.
    Evans CA, Fries HE, Ward KW.
    Chem Biol Interact; 2005 Feb 28; 152(1):25-36. PubMed ID: 15766920
    [Abstract] [Full Text] [Related]

  • 12. Drug discovery and natural products: end of an era or an endless frontier?
    Li JW, Vederas JC.
    Science; 2009 Jul 10; 325(5937):161-5. PubMed ID: 19589993
    [Abstract] [Full Text] [Related]

  • 13. From toxic precursors to safe drugs. Mechanisms and relevance of idiosyncratic drug reactions.
    Petersen KU.
    Arzneimittelforschung; 2002 Jul 10; 52(6):423-9. PubMed ID: 12109041
    [Abstract] [Full Text] [Related]

  • 14. Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching.
    Leblanc A, Shiao TC, Roy R, Sleno L.
    Rapid Commun Mass Spectrom; 2010 May 15; 24(9):1241-50. PubMed ID: 20391594
    [Abstract] [Full Text] [Related]

  • 15. Recent advances in applications of liquid chromatography-tandem mass spectrometry to the analysis of reactive drug metabolites.
    Ma S, Zhu M.
    Chem Biol Interact; 2009 Apr 15; 179(1):25-37. PubMed ID: 18848531
    [Abstract] [Full Text] [Related]

  • 16. Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development.
    Thompson RA, Isin EM, Li Y, Weaver R, Weidolf L, Wilson I, Claesson A, Page K, Dolgos H, Kenna JG.
    Chem Biol Interact; 2011 Jun 30; 192(1-2):65-71. PubMed ID: 21074519
    [Abstract] [Full Text] [Related]

  • 17. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N, Makino C, Murayama N.
    Chem Res Toxicol; 2007 Mar 30; 20(3):455-64. PubMed ID: 17309281
    [Abstract] [Full Text] [Related]

  • 18. Activity-based protein profiling for natural product target discovery.
    Krysiak J, Breinbauer R.
    Top Curr Chem; 2012 Mar 30; 324():43-84. PubMed ID: 22025071
    [Abstract] [Full Text] [Related]

  • 19. Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry.
    Yan Z, Maher N, Torres R, Caldwell GW, Huebert N.
    Rapid Commun Mass Spectrom; 2005 Mar 30; 19(22):3322-30. PubMed ID: 16235238
    [Abstract] [Full Text] [Related]

  • 20. Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.
    Kostiainen R, Kotiaho T, Kuuranne T, Auriola S.
    J Mass Spectrom; 2003 Apr 30; 38(4):357-72. PubMed ID: 12717747
    [Abstract] [Full Text] [Related]

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